CAJ | 학술논문

目的：探讨血清胱抑素（CysC）及血清β2‐微球蛋白（β2‐MG）在评估妊娠期高血压疾病（HDCP）患者早期肾功能损伤中的临床价值。方法采用全自动生化分析仪检测108例 HDCP 患者（妊娠期高血压组41例，轻度子痫前期组30例，重度子痫前期组37例）及孕周相近的健康单胎妊娠妇女（对照组40例）血清中 CysC 、β2‐MG 、肌酐（Cr）的水平。结果妊娠期高血压组、轻度子痫前期组、重度子痫前期组患者血清 CysC 、β2‐MG 水平均显著高于对照组（P＜0．05）；妊娠期高血压组、轻度子痫前期组、重度子痫前期组3组间血清 CysC 、β2‐MG 水平比较，差异均有统计学意义（妊娠期高血压组＜轻度子痫前期组＜重度子痫前期组，P＜0．05）。妊娠期高血压组、轻度子痫前期组和对照组之间血清 Cr 水平比较差异均无统计学意义（P＞0．05），而重度子痫前期组与对照组之间血清 Cr 水平差异有统计学意义（P＜0．05）。相关分析结果显示 HDCP 患者血清 CysC 与β2‐MG 、Cr 呈正相关。结论联合检测血清 CysC 、β2‐MG 、Cr 对判断 HDCP 孕妇病情严重程度及诊断早期肾功能损伤具有重要的临床价值。
목적：탐토혈청광억소（CysC）급혈청β2‐미구단백（β2‐MG）재평고임신기고혈압질병（HDCP）환자조기신공능손상중적림상개치。방법채용전자동생화분석의검측108례 HDCP 환자（임신기고혈압조41례，경도자간전기조30례，중도자간전기조37례）급잉주상근적건강단태임신부녀（대조조40례）혈청중 CysC 、β2‐MG 、기항（Cr）적수평。결과임신기고혈압조、경도자간전기조、중도자간전기조환자혈청 CysC 、β2‐MG 수평균현저고우대조조（P＜0．05）；임신기고혈압조、경도자간전기조、중도자간전기조3조간혈청 CysC 、β2‐MG 수평비교，차이균유통계학의의（임신기고혈압조＜경도자간전기조＜중도자간전기조，P＜0．05）。임신기고혈압조、경도자간전기조화대조조지간혈청 Cr 수평비교차이균무통계학의의（P＞0．05），이중도자간전기조여대조조지간혈청 Cr 수평차이유통계학의의（P＜0．05）。상관분석결과현시 HDCP 환자혈청 CysC 여β2‐MG 、Cr 정정상관。결론연합검측혈청 CysC 、β2‐MG 、Cr 대판단 HDCP 잉부병정엄중정도급진단조기신공능손상구유중요적림상개치。
Objective To explore the clinical value of detecting serum cystatinC (CysC) combined with β2‐microglobulin(β2‐MG) in assessing early kidney damage for patients with hypertensive disorder complicating pregnancy (HDCP) .Methods Totally 108 patients with HDCP were selected ,including 41 cases of gestational hypertension ,30 cases of mild preeclampsia ,37 cases of se‐vere preeclampsia ,moreover ,40 normal pregnant women were selected as control .The levels of serum CysC ,serum β2‐MG and ser‐um creatinine(Cr) were tested with automatic biochemistry analysator .Results The levels of serum CysC and β2‐MG in gestational hypertension group ,mild preeclampsia group and severe preeclampsia group were significantly higher than the control group (P<0 .05) .There were significantly differences among gestational hypertension group ,mild preeclampsia group and severe preeclampsia group of levels of CysC and β2‐MG (gestational hypertension group < mild preeclampsia group < severe preeclampsia group ,P<0 .05) .The level of Cr of severe‐preeclampsia group was significantly higher than the control (P< 0 .05) ,but it had no significant difference among gestational hypertension group ,mild preeclampsia group and control group (P> 0 .05) .In addition ,the results of correlation analysis showed there was a positive correlation among Cys‐C ,β2‐MG and Cr in the patients with HDCP .Conclusion There will be an important clinical value to evaluate the progression of the disease and diagnose early kidney damage through joint detectation of serum Cys‐C ,β2‐MG and and Cr .