CAJ | 학술논문

目的了解DM/PM患者主要死因的变化,分析影响DM/PM患者病死率和主要死因的因素.方法回顾分析1985年8月至2013年4月北京协和医院DM/PM住院患者的死亡病例.应用x2检验和Fisher确切概率法对计数资料进行分析;用独立样本的t检验对计量资料进行分析.结果近28年DM/PM的住院患者共1 443例,死亡患者74例,总病死率5.1％,其中女性48例(4.7％),男性26例(6.3％);DM/PM最常见的死因为感染(46例,62.2％)和呼吸系统受累(11例,14.9％).DM/PM发病后第1年内死亡人数最多,占总死亡人数的79.7％ (59/74),感染和呼吸系统受累是发病后第1年内最常见的死因.近28年住院DM/PM患者的病死率在1996-2000年达到高峰(12.3％,18/146);DM/PM患者最常见的死亡原因为感染.结论感染、呼吸系统受累是DM/PM的最主要死因,DM/PM发病第1年内死亡最多见.
목적 료해DM/PM환자주요사인적변화,분석영향DM/PM환자병사솔화주요사인적인소.방법 회고분석1985년8월지2013년4월북경협화의원DM/PM주원환자적사망병례.응용x2검험화Fisher학절개솔법대계수자료진행분석;용독립양본적t검험대계량자료진행분석.결과 근28년DM/PM적주원환자공1 443례,사망환자74례,총병사솔5.1％,기중녀성48례(4.7％),남성26례(6.3％);DM/PM최상견적사인위감염(46례,62.2％)화호흡계통수루(11례,14.9％).DM/PM발병후제1년내사망인수최다,점총사망인수적79.7％ (59/74),감염화호흡계통수루시발병후제1년내최상견적사인.근28년주원DM/PM환자적병사솔재1996-2000년체도고봉(12.3％,18/146);DM/PM환자최상견적사망원인위감염.결론 감염、호흡계통수루시DM/PM적최주요사인,DM/PM발병제1년내사망최다견.
Objective To investigate the changes of major causes of death in patient with dermatomyositis/polymyositis (DM/PM) and the factors affecting the mortality of DM/PM in the past 28 years.Methods Death cases with DM/PM from 1985 to 2013 were retrospectively analyzed.x2 test and Fisher exact test was used for count data analysis;independent samples t-test measurement was used for data analysis;P＜0.05 was consi-dered statistically significant.Results Out of 1 443 patients with DM/PM, 74 died, in whom 48 were female and 26 were male.The mortality rate was 4.7％ among female and 6.3％ among male cases and the total in-hospital mortality of DM/PM was 5.1％.The two most common causes of death in patients with DM/PM were infection and respiratory involvement, accounting for 62.2％ (46/74) and 14.9％ (11/74) respectively.Death occurred most commonly in the first year after disease onset, accounting for 79.7％(59/74).The leading causes of death in the first year were infection and respiratory involvement.The mortality of DM/PM patients was peaked 12.3％(18/146) from 1996 to 2000;infection was the most frequent cause of death.Conclusion Infection and respiratory involvement are the main causes of death in DM/PM.Death occurrs most commonly in the first year after disease onset.