CAJ | 학술논문

目的：探讨鼻咽癌患者放疗前后血清上皮型钙黏蛋白（SE-CAD ）、同型半胱氨酸（Hcy ）、血小板源性生长因子（PDGF-BB）水平的变化及临床意义。方法采用免疫化学法和ELISA法对30例鼻咽癌患者（研究组）进行了放疗前后血清SE-CAD、Hcy和PDGF-BB水平检测，并与35例健康人（对照组）作比较。结果研究组治疗前及放疗后1个月血清SE-CAD、Hcy和PDGF-BB水平均明显高于对照组，差异均有统计学意义（F＝2．352、2．683、3．125，均为 P＜0．05）。复发患者上述3项指标明显高于未复发患者，差异有统计学意义（P＜0．05）。SE-CAD、Hcy和 PDGF-BB表达均为阴性的患者5年生存率为72．0％，SE-CAD、Hcy和PDGF-BB表达均为阳性的患者5年生存率为62．5％，但差异无统计学意义（P＞0．05）。结论鼻咽癌患者放疗前后血清SE-CAD、Hcy和PDGF-BB水平的变化与鼻咽癌的病情和预后密切相关。
목적：탐토비인암환자방료전후혈청상피형개점단백（SE-CAD ）、동형반광안산（Hcy ）、혈소판원성생장인자（PDGF-BB）수평적변화급림상의의。방법채용면역화학법화ELISA법대30례비인암환자（연구조）진행료방료전후혈청SE-CAD、Hcy화PDGF-BB수평검측，병여35례건강인（대조조）작비교。결과연구조치료전급방료후1개월혈청SE-CAD、Hcy화PDGF-BB수평균명현고우대조조，차이균유통계학의의（F＝2．352、2．683、3．125，균위 P＜0．05）。복발환자상술3항지표명현고우미복발환자，차이유통계학의의（P＜0．05）。SE-CAD、Hcy화 PDGF-BB표체균위음성적환자5년생존솔위72．0％，SE-CAD、Hcy화PDGF-BB표체균위양성적환자5년생존솔위62．5％，단차이무통계학의의（P＞0．05）。결론비인암환자방료전후혈청SE-CAD、Hcy화PDGF-BB수평적변화여비인암적병정화예후밀절상관。
Objective To investigate the change and clinic value of serum E-cadherin(SE-CAD) ,homocysteine(Hcy) ,platelet-derived growth factor(PDGF-BB) in patients with nasopharyngeal carcinoma before and after radiotherapy .Methods Immuno-chemistry and ELISA method were used to detect serum SE-CAD ,PDGF-BB and Hcy levels in 30 patients with nasopharyngeal car-cinoma(study group) ,and compared with 35 healthy controls(control group) .Results The serum SE-CAD ,Hcy ,PDGF-BB in pa-tients with nasopharyngeal carcinoma before and after radiotherapy were significant different with those of the control group(F=2 .352 ,2 .683 ,3 .125 ,all of them P<0 .05) ,the levels in the recurrence patients were significant higher than those of no recurrence patients(P<0 .05) .The five year survival rate of negative SE-CAD ,Hcy and PDGF-BB patients and positive patients were 72 .0% , 62 .5% respectively ,but the difference had no significance(P>0 .05) .Conclusion The change of SE-CAD ,Hcy ,PDGF-BB in pa-tients with nasopharyngeal carcinoma before and after radiotherapy are closely related to the severity and prognosis of nasopharyn-geal carcinoma ,which is of great clinical value .