CAJ | 학술논문

目的：探讨脂蛋白相关磷脂酶A2（LP-PLA2）水平检测对2型糖尿病（T2DM ）并发动脉粥样硬化患者的临床意义。方法测定47例T2DM并发动脉粥样硬化患者（患者组），94例健康体检者（对照组）的 LP-PLA2、胆固醇（CHO）、三酰甘油（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）水平，同时收集上述人群的年龄、性别等相关资料，对两组的检测结果进行比较。结果患者组与对照组在年龄、性别、CHO、TG、HDL、LDL水平方面比较，差异无统计学意义（P＞0．05）；患者组LP-PLA2水平高于对照组，差异有统计学意义（P＜0．05）；非条件Logistic多元回归分析显示，LP-PLA2水平是有统计学意义（P＜0．05）的危险因素。结论 LP-PLA2水平是T2DM患者并发动脉粥样硬化的危险因素，其检测对 T2DM 人群动脉粥样硬化病变的发现具有一定价值。
목적：탐토지단백상관린지매A2（LP-PLA2）수평검측대2형당뇨병（T2DM ）병발동맥죽양경화환자적림상의의。방법측정47례T2DM병발동맥죽양경화환자（환자조），94례건강체검자（대조조）적 LP-PLA2、담고순（CHO）、삼선감유（TG）、저밀도지단백（LDL）、고밀도지단백（HDL）수평，동시수집상술인군적년령、성별등상관자료，대량조적검측결과진행비교。결과환자조여대조조재년령、성별、CHO、TG、HDL、LDL수평방면비교，차이무통계학의의（P＞0．05）；환자조LP-PLA2수평고우대조조，차이유통계학의의（P＜0．05）；비조건Logistic다원회귀분석현시，LP-PLA2수평시유통계학의의（P＜0．05）적위험인소。결론 LP-PLA2수평시T2DM환자병발동맥죽양경화적위험인소，기검측대 T2DM 인군동맥죽양경화병변적발현구유일정개치。
Objective To investigate the clinical significance of lipoprotein-associated phospholipase A2(LP-PLA2) measure-ment for type 2 diabetes mellitus(T2DM) patients combined with atherosclerosis .Methods The concentrations of LP-PLA2 ,cho-lesterol(CHO) ,triglyceride (TG) ,low density lipoprotein(LDL) ,high density lipoprotein(HDL) were measured for 47 T2DM pa-tients combined with atherosclerosis(patient group) and 94 healthy people who just underwent healthy examination and were proved to be healthy(control group) ,meanwhile the age and gender information of those people were collected .Then the tests results were compared between the two groups .Results There was no significant difference in age ,gender ,CHO ,HDL ,TG ,LDL between the two patient and control group(P>0 .05);Plasma LP-PLA2 level in patient group was higher than that in control group ,and the difference was statistically significant(P<0 .05) .Non-conditional Logistic regression analysis showed that the LP-PLA2 level was the risk factor with statistical significance(P<0 .05) .Conclusion LP-PLA2 concentration is an independent risk factor for athero-sclerosis in T2DM patients ,and its measurement has certain value for the diagnosis of atherosclerosis in T2DM patients .