CAJ | 학술논문

目的：观察肝细胞损伤时肝硬化患者血清前清蛋白和胆碱酯酶的变化特点，探讨2项指标在肝硬化患者诊断、治疗及预后的临床意义。方法2013年7～12月来该院就诊并确诊的肝硬化患者45例纳入研究组，同期体检健康者98例纳入对照组，采用日立7170全自动生化分析仪进行前清蛋白、胆碱酯酶检测，前清蛋白检测采用免疫比浊法，胆碱酯酶检测采用丁酰硫代胆碱底法。与对照组比较，研究组治疗前后的前清蛋白及胆碱酯酶水平，以及异常率。结果研究组患者各个治疗阶段的前清蛋白及胆碱酯酶水平与对照组比较均有不同程度的下降，差异有统计学意义（P＜0．05）。肝硬化患者治疗后与治疗前、治疗中前清蛋白的异常率差异有统计学意义（χ2＝10．08，P＜0．05），胆碱酯酶治疗后与治疗前、治疗中的异常率差异无统计学意义（ P＞0．05）。结论血清前清蛋白是肝细胞损伤的一项敏感指标，其变化可以反映病情的发展状况，对肝硬化患者的疗效及预后判断有重要的临床意义。
목적：관찰간세포손상시간경화환자혈청전청단백화담감지매적변화특점，탐토2항지표재간경화환자진단、치료급예후적림상의의。방법2013년7～12월래해원취진병학진적간경화환자45례납입연구조，동기체검건강자98례납입대조조，채용일립7170전자동생화분석의진행전청단백、담감지매검측，전청단백검측채용면역비탁법，담감지매검측채용정선류대담감저법。여대조조비교，연구조치료전후적전청단백급담감지매수평，이급이상솔。결과연구조환자각개치료계단적전청단백급담감지매수평여대조조비교균유불동정도적하강，차이유통계학의의（P＜0．05）。간경화환자치료후여치료전、치료중전청단백적이상솔차이유통계학의의（χ2＝10．08，P＜0．05），담감지매치료후여치료전、치료중적이상솔차이무통계학의의（ P＞0．05）。결론혈청전청단백시간세포손상적일항민감지표，기변화가이반영병정적발전상황，대간경화환자적료효급예후판단유중요적림상의의。
Objective To observe the change characteristics of serum prealbumin and cholinesterase in the liver cirrhosis pa-tients ,and to discusses the determination of these two indicators in diagnosis ,treatment and prognosis of clinical significance in pa-tients with liver cirrhosis .Methods A total of 45 liver cirrhosis patients diagnosis in our hospital from July to December 2013 were recruited into study group ,at the same time 98 healthy people were recruited into control group .The Hitachi 7170 automatic bio-chemical analyzer was used to detected serum prealbumin and cholinesterase ,the former was detected by immunoturbidimetry meth-od ,the latter was detected by butyryl glucosinolates choline bottom method .The levels and abnormal rates of the two indicators be-fore and after treatment in the study group were compared with those of the control group .Results The serum prealbumin and cho-linesterase at different stage in the study group were significant lower than those of the control group(P<0 .05) .The abnormal rate of serum prealbumin after treatment was significant different with those among and before treatment in patients with cirrhosis (χ2 =10 .08 ,P<0 .05) ,but there were no significant difference on cholinesterase(P>0 .05) .Conclusion The serum prealbumin is a sensitive indicator of liver cell damage ,its change could reflect the condition of treatment and development status ,which has im-portant clinical significance on judging the prognosis of patients with liver cirrhosis .