CAJ | 학술논문

目的：探讨脑梗死患者血清雌二醇（E2）与β-淀粉样蛋白（β-A P ）的关系。方法选取2011年1月至2014年6月该院收治的46例女性脑梗死患者为观察组，依据神经功能缺损评分标准分为轻度组20例，中度组16例，重度组10例，根据梗死灶体积大小分为小梗死灶患者21例，中等梗死灶14例，大梗死灶11例。另选择同期该院门诊体检健康女性64例为对照组。检测受试者血清E2，血清、脑脊液β-AP水平，并进行比较和相关性分析。结果观察组血清β-AP、脑脊液β-AP水平均高于对照组，观察组血清E2水平明显低于对照组，差异均有统计学意义（P＜0．05）。随着脑梗死严重程度加重，血清β-AP、脑脊液β-AP水平均呈上升趋势，血清E2水平呈明显下降趋势，轻、中、重度组两两比较差异均有统计学意义（P＜0．05）。大梗死灶患者血清β-AP、脑脊液β-AP水平均高于中等、小梗死灶患者，大梗死灶患者血清E2水平低于中、小梗死灶患者，差异有统计学意义（P＜0．05），但中等、小梗死灶组血清β-AP、脑脊液β-AP、血清E2水平差异均无统计学意义（P＞0．05）。血清 E2与血清β-AP、脑脊液β-AP的表达均呈显著负相关（ r＝－0．428、P＝0．009，r＝－0．476、P＝0．005）。结论β-A P在脑梗死患者脑脊液、血清中高表达，与脑梗死病情严重程度密切相关。脑梗死患者脑脊液、血清β-A P水平与血清E2水平呈负相关。
목적：탐토뇌경사환자혈청자이순（E2）여β-정분양단백（β-A P ）적관계。방법선취2011년1월지2014년6월해원수치적46례녀성뇌경사환자위관찰조，의거신경공능결손평분표준분위경도조20례，중도조16례，중도조10례，근거경사조체적대소분위소경사조환자21례，중등경사조14례，대경사조11례。령선택동기해원문진체검건강녀성64례위대조조。검측수시자혈청E2，혈청、뇌척액β-AP수평，병진행비교화상관성분석。결과관찰조혈청β-AP、뇌척액β-AP수평균고우대조조，관찰조혈청E2수평명현저우대조조，차이균유통계학의의（P＜0．05）。수착뇌경사엄중정도가중，혈청β-AP、뇌척액β-AP수평균정상승추세，혈청E2수평정명현하강추세，경、중、중도조량량비교차이균유통계학의의（P＜0．05）。대경사조환자혈청β-AP、뇌척액β-AP수평균고우중등、소경사조환자，대경사조환자혈청E2수평저우중、소경사조환자，차이유통계학의의（P＜0．05），단중등、소경사조조혈청β-AP、뇌척액β-AP、혈청E2수평차이균무통계학의의（P＞0．05）。혈청 E2여혈청β-AP、뇌척액β-AP적표체균정현저부상관（ r＝－0．428、P＝0．009，r＝－0．476、P＝0．005）。결론β-A P재뇌경사환자뇌척액、혈청중고표체，여뇌경사병정엄중정도밀절상관。뇌경사환자뇌척액、혈청β-A P수평여혈청E2수평정부상관。
Objective To study the relationship between serum Estradiol(E2 ) andβ-amyloid protein(β-AP) in patients with cer-ebral infarction .Methods A total of 46 female patients with cerebral infarction were selected from 2011 January to 2014 June into observation group ,46 cases were divided as 20 cases in mild group ,16 cases in moderate group ,10 cases in severe group on the basis of neural function defect score standard ,according to the size of infarct volume 46 patients were divided into small infarct volume group with 21 patients ,moderate infarct volume group with 14 cases ,larger infarction volume group with 11 cases .In the same peri-od ,64 healthy women were recruited into control group .Serum E2 ,β-AP levels of serum and cerebrospinal fluid were detected and compared ,and the relationship of serum E2 andβ-AP level in serum ,cerebrospinal fluid were analyzed .Results Theβ-AP levels in serum and cerebrospinal fluid in observation group were higher than those of control group ,the serum E2 level was significant lower than that of the control group ,the differences were significant(P<0 .05) .With more severe cerebral infarction ,β-AP levels in serum cerebrospinal fluid showed an upward trend ,with more severe cerebral infarction ,the serum level of E2 was significantly decreased , andβ-AP ,E2 levels in mild ,moderate ,severe group had significant differences(P<0 .05) .Theβ-AP levels of serum and cerebrospi-nal fluid in higher infarct group were higher than those in small ,moderate infarction group ,but E2 levels were lower than those in small ,moderate infarction group ,the differences had significant(P<0 .05) .There were no significant difference inβ-AP of serum and cerebrospinal fluid ,Serum E2 level between small and moderate infarction group(P>0 .05) .The expression of serum E2 andβ-AP in serum and cerebrospinal fluid were negatively correlated(r= -0 .428 ,P=0 .009;r= -0 .476 ,P=0 .005) .Conclusion β-AP levels in serum and cerebrospinal fluid in patients with cerebral infarction are high ,closely related with the severity of cerebral in-farction .β-AP levels of cerebrospinal fluid ,serum in cerebral infarction patients are negatively related to the level of serum E2 .