中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
Chinese Journal of Rheumatology
2015年
10期
662-668
,共7页
杨春军%王君颖%孙春艳%张清
楊春軍%王君穎%孫春豔%張清
양춘군%왕군영%손춘염%장청
关节炎,类风湿%抑郁%Meta分析
關節炎,類風濕%抑鬱%Meta分析
관절염,류풍습%억욱%Meta분석
Arthritis,rheumatoid%Depression%Meta-analysis
目的 评价我国RA患者抑郁的患病情况.方法 检索Cochrane图书馆、Medline、EMbase、中国期刊全文数据库(CNKI)、中国生物医学数据库(CBM)、中文科技期刊数据库(VIP)及万方数据库中关于我国成人RA患者抑郁的相关文献,进行文献质量评价后,应用R 3.2.0软件进行Meta分析.结果 共纳入文献25篇,样本总量4 830例,抑郁患者2 712例,抑郁患病率经分析合并效应量为44.7％[95％CI(37.5％,52.0％)],与纳入研究中抑郁率中位数43.0％接近,高于全球平均水平38.8％ [95％CI(34.0％,43.0％)];其中8篇报道了轻度抑郁率和中重度抑郁率,样本含量1 028例,轻度抑郁311例,中重度219例;抑郁患病率分别为30.2％[95％CI(22.1％,40.0％)],16.5％[95％CI(9.6％,26.9％)].亚组分析结果显示女性RA患者抑郁率高于男性,中西部地区抑郁率高于东部地区,使用老年抑郁量表检出的抑郁率高于其他量表检出率.敏感性分析显示,合并效应结果具有较好的稳定性和可靠性.结论 我国RA患者抑郁率高达44.7％,应引起医护人员的高度重视.
目的 評價我國RA患者抑鬱的患病情況.方法 檢索Cochrane圖書館、Medline、EMbase、中國期刊全文數據庫(CNKI)、中國生物醫學數據庫(CBM)、中文科技期刊數據庫(VIP)及萬方數據庫中關于我國成人RA患者抑鬱的相關文獻,進行文獻質量評價後,應用R 3.2.0軟件進行Meta分析.結果 共納入文獻25篇,樣本總量4 830例,抑鬱患者2 712例,抑鬱患病率經分析閤併效應量為44.7％[95％CI(37.5％,52.0％)],與納入研究中抑鬱率中位數43.0％接近,高于全毬平均水平38.8％ [95％CI(34.0％,43.0％)];其中8篇報道瞭輕度抑鬱率和中重度抑鬱率,樣本含量1 028例,輕度抑鬱311例,中重度219例;抑鬱患病率分彆為30.2％[95％CI(22.1％,40.0％)],16.5％[95％CI(9.6％,26.9％)].亞組分析結果顯示女性RA患者抑鬱率高于男性,中西部地區抑鬱率高于東部地區,使用老年抑鬱量錶檢齣的抑鬱率高于其他量錶檢齣率.敏感性分析顯示,閤併效應結果具有較好的穩定性和可靠性.結論 我國RA患者抑鬱率高達44.7％,應引起醫護人員的高度重視.
목적 평개아국RA환자억욱적환병정황.방법 검색Cochrane도서관、Medline、EMbase、중국기간전문수거고(CNKI)、중국생물의학수거고(CBM)、중문과기기간수거고(VIP)급만방수거고중관우아국성인RA환자억욱적상관문헌,진행문헌질량평개후,응용R 3.2.0연건진행Meta분석.결과 공납입문헌25편,양본총량4 830례,억욱환자2 712례,억욱환병솔경분석합병효응량위44.7％[95％CI(37.5％,52.0％)],여납입연구중억욱솔중위수43.0％접근,고우전구평균수평38.8％ [95％CI(34.0％,43.0％)];기중8편보도료경도억욱솔화중중도억욱솔,양본함량1 028례,경도억욱311례,중중도219례;억욱환병솔분별위30.2％[95％CI(22.1％,40.0％)],16.5％[95％CI(9.6％,26.9％)].아조분석결과현시녀성RA환자억욱솔고우남성,중서부지구억욱솔고우동부지구,사용노년억욱량표검출적억욱솔고우기타량표검출솔.민감성분석현시,합병효응결과구유교호적은정성화가고성.결론 아국RA환자억욱솔고체44.7％,응인기의호인원적고도중시.
Objective To evaluate the rate of depression in adult rheumatoid arthritis (RA) patients in China.Methods Literature search was conducted to collect studies on the prevalence of depression in adult RA patients in Cochrane library, Medline, EMbase, China National Knowledge Internet (CNKI),China Biology Medicine (CBM), Chinese science & technology journal database (VIP) and Wanfang database.Data were analyzed by R 3.2.0 software after evaluating all data.Results A total of 25 studies, including a total size of 4 830 and 2 712 patients of depression, were eligible for inclusion in the review.The prevalence of depression by analyzing the effect size was 44.7％ [95％CI (37.5％, 52.0％)], which was close to the median of 43.0％ from all studies included and higher than the global rate 38.8％ [95％CI (34％, 43％)].Eight studies, including the sample size of 1 028 cases, 311 cases of mild depressive disorders and 219 cases of moderate or severe depressive disorders, reported the prevalence levels of 30.2％ [30.2％CI (22.1％, 40.0％)] and 16.5％ [95％CI (9.6％,26.9％)], respectively.Subgroup analysis showed that the depression rate of female RA patients was higher than male, the depression rate in the central and western areas were higher than that of the eastern region, the prevalence level estimated by the Geriatric Depression Scale (GDS) was higher than estimated by other tools.Sensitivity analysis showed that the pooled effect size had good stability and reliability.Conclusion The prevalence rate of depression in adult RA patients is 44.7％, suggesting that medical staff should pay much attention to depression in adult RA patients.
