国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
International Journal of Respiration
2015年
20期
1526-1530
,共5页
过敏性鼻炎%支气管哮喘%症状%肺功能%小气道功能
過敏性鼻炎%支氣管哮喘%癥狀%肺功能%小氣道功能
과민성비염%지기관효천%증상%폐공능%소기도공능
Allergic rhinitis%Bronchial asthma%Symptom%Pulmonary lung function%Small airway function
目的 总结并比较合并与未合并过敏性鼻炎(AR)轻度持续支气管哮喘(简称哮喘)患者临床症状及小气道功能特征.方法 采用回顾性分析总结并比较2013年8月至2014年8月门诊初诊轻度持续哮喘患者65例临床症状分布、肺功能指标及呼出气一氧化氮(FeNO)结果,将患者分为AR组与非过敏性鼻炎(NAR)组并比较2组间上述结果的差异.结果 患者平均年龄(43.90±13.63)岁,男:女为1:2.4.AR组皮肤点刺试验尘螨阳性比例、血嗜酸粒细胞比例、嗜酸粒细胞绝对值计数、IgE水平较NAR组升高,差异有统计学意义(79.41％ vs 37.50％,x2=11.19,P＜0.01);[(7.28±3.06)％ vs(4.31±2.07)％,t=2.35,P ＜0.05];[(0.63±0.29)×109/L vs (0.42±0.16)×109/L,t=2.20, P＜0.05];[(240.71±68.29) U/ml vs (119.06±65.39) U/ml,t=2.88,P＜0.05)];胸闷、气短、全身乏力(活动后明显)、心悸为最常见的临床症状,所占比例分别为98.46％、98.46％、72.31％、66.15％,NAR组心悸症状较AR组高,差异有统计学意义(x2=5.56,P＜0.05);AR组咳嗽比例较NAR组高,差异有统计学意义(x2 =5.36,P＜0.05);AR组吸入支气管扩张剂前FEF25-75及FEF75较NAR组降低,差异有统计学意义[(61.07±23.64)％ vs (86.00±28.70)％,t=3.21,P＜0.01];[(62.7±25.25)％vs(94.78±31.95)％,t=2.32,P＜0.05)].AR组及NAR组FeNO值分别为48(7～266) ppb、17.5(5～131) ppb,差异有统计学意义(P=0.005 9).结论 轻度持续哮喘患者症状存在异质性;合并AR轻度哮喘患者存在小气道功能受损,其机制与气道嗜酸粒细胞炎症及变应性体质相关.
目的 總結併比較閤併與未閤併過敏性鼻炎(AR)輕度持續支氣管哮喘(簡稱哮喘)患者臨床癥狀及小氣道功能特徵.方法 採用迴顧性分析總結併比較2013年8月至2014年8月門診初診輕度持續哮喘患者65例臨床癥狀分佈、肺功能指標及呼齣氣一氧化氮(FeNO)結果,將患者分為AR組與非過敏性鼻炎(NAR)組併比較2組間上述結果的差異.結果 患者平均年齡(43.90±13.63)歲,男:女為1:2.4.AR組皮膚點刺試驗塵螨暘性比例、血嗜痠粒細胞比例、嗜痠粒細胞絕對值計數、IgE水平較NAR組升高,差異有統計學意義(79.41％ vs 37.50％,x2=11.19,P＜0.01);[(7.28±3.06)％ vs(4.31±2.07)％,t=2.35,P ＜0.05];[(0.63±0.29)×109/L vs (0.42±0.16)×109/L,t=2.20, P＜0.05];[(240.71±68.29) U/ml vs (119.06±65.39) U/ml,t=2.88,P＜0.05)];胸悶、氣短、全身乏力(活動後明顯)、心悸為最常見的臨床癥狀,所佔比例分彆為98.46％、98.46％、72.31％、66.15％,NAR組心悸癥狀較AR組高,差異有統計學意義(x2=5.56,P＜0.05);AR組咳嗽比例較NAR組高,差異有統計學意義(x2 =5.36,P＜0.05);AR組吸入支氣管擴張劑前FEF25-75及FEF75較NAR組降低,差異有統計學意義[(61.07±23.64)％ vs (86.00±28.70)％,t=3.21,P＜0.01];[(62.7±25.25)％vs(94.78±31.95)％,t=2.32,P＜0.05)].AR組及NAR組FeNO值分彆為48(7～266) ppb、17.5(5～131) ppb,差異有統計學意義(P=0.005 9).結論 輕度持續哮喘患者癥狀存在異質性;閤併AR輕度哮喘患者存在小氣道功能受損,其機製與氣道嗜痠粒細胞炎癥及變應性體質相關.
목적 총결병비교합병여미합병과민성비염(AR)경도지속지기관효천(간칭효천)환자림상증상급소기도공능특정.방법 채용회고성분석총결병비교2013년8월지2014년8월문진초진경도지속효천환자65례림상증상분포、폐공능지표급호출기일양화담(FeNO)결과,장환자분위AR조여비과민성비염(NAR)조병비교2조간상술결과적차이.결과 환자평균년령(43.90±13.63)세,남:녀위1:2.4.AR조피부점자시험진만양성비례、혈기산립세포비례、기산립세포절대치계수、IgE수평교NAR조승고,차이유통계학의의(79.41％ vs 37.50％,x2=11.19,P＜0.01);[(7.28±3.06)％ vs(4.31±2.07)％,t=2.35,P ＜0.05];[(0.63±0.29)×109/L vs (0.42±0.16)×109/L,t=2.20, P＜0.05];[(240.71±68.29) U/ml vs (119.06±65.39) U/ml,t=2.88,P＜0.05)];흉민、기단、전신핍력(활동후명현)、심계위최상견적림상증상,소점비례분별위98.46％、98.46％、72.31％、66.15％,NAR조심계증상교AR조고,차이유통계학의의(x2=5.56,P＜0.05);AR조해수비례교NAR조고,차이유통계학의의(x2 =5.36,P＜0.05);AR조흡입지기관확장제전FEF25-75급FEF75교NAR조강저,차이유통계학의의[(61.07±23.64)％ vs (86.00±28.70)％,t=3.21,P＜0.01];[(62.7±25.25)％vs(94.78±31.95)％,t=2.32,P＜0.05)].AR조급NAR조FeNO치분별위48(7～266) ppb、17.5(5～131) ppb,차이유통계학의의(P=0.005 9).결론 경도지속효천환자증상존재이질성;합병AR경도효천환자존재소기도공능수손,기궤제여기도기산립세포염증급변응성체질상관.
Objective To summarize and compare the clinical symptoms and small airway function characteristics of mild persistent asthma patients with and without allergic rhinitis (AR).Methods A retrospective analysis was performed for 65 cases diagnosed by mild persist asthma during August 2013 to August 2014.The patients were divided into AR group and non-allergic rhinitis group (NAR).Clinical information including results of skin prick test, blood percentage of eosinophils, absolute value of eosinophils,serum IgE level, symptoms, pulmonary lung function results, fractional exhaled nitric oxide (FeNO) were collected and compared between two groups.Results The mean age was (43.90± 13.63) years old with male: female ratio 1 : 2.4.The percentage of positive skin prick test, blood eosinophil counts,eosinophil absolute value, IgE levels on AR group were higher than NAR group with statistically significant differences [79.41％ vs 37.50％, x2 =11.19, P ＜0.01;(7.28±3.06) ％ vs (4.31± 2.07) ％, t =2.35, P ＜0.05;(0.63 ± 0.29) × 109/L vs (0.42 ± 0.16) × 109/L, t =2.20, P ＜0.05;(240.71 ± 68.29) U/mlvs (119.06±65.39) U/ml, t =2.88, P ＜0.05].Chest tightness, shortness of breath,malaise after activity, heart palpitation were most four symptoms frequently presented with percentage of 98.46％ ,98.46％ ,72.31％ and 66.15％.Heart palpation occurred more frequently in NAR group than in the AR group (x2 =5.56, P ＜0.05).Cough occurred in NAR group less than in AR group (x2 =5.36,P ＜0.05).The values of FEF25-75 and FEF75 suggesting small airway function were significantly lower in AR group than in NAR group [(61.07±23.64) ％ vs (86.00±28.70) ％, t =3.21, P ＜0.01;(62.7± 25.25) ％ vs (94.78± 31.95) ％, t =2.32, P ＜0.05].FeNO values in AR group was higher than in NAR group [48 (7～266) ppb vs 17.5 (5～131) ppb, P =0.005 9].Conclusions The symptoms complained by mild persistent asthma patients show heterogeneity.The small airway dysfunction exists in the patients complicated with AR, which is associated with airway eosinophilic inflammation and self-atopic constitution.
