医学研究与教育
醫學研究與教育
의학연구여교육
Medical Research and Education
2015年
4期
50-55
,共6页
瞿海龙%梁璐%边剑飞%张冰
瞿海龍%樑璐%邊劍飛%張冰
구해룡%량로%변검비%장빙
再生医学%干细胞%心肌
再生醫學%榦細胞%心肌
재생의학%간세포%심기
regenerative medicine%stem cells%myocardium
如何实现人类心肌的再生,科研工作者和临床医生已经为之努力了近一个世纪。1953年,实施了第一例室间隔缺损修复手术,1967年第一例心脏移植成功,2002年骨髓来源的细胞首次移植到心肌内,使心肌的修复取得重大进步。然而慢性心力衰竭仍是世界范围内的难题。为什么实现心肌的再生面临巨大的挑战?要实现心肌的再生还有多远?细胞移植技术近年已取得突飞猛进的进步,许多大型动物实验结果带来了曙光和挑战。将对心肌再生的历史和临床研究进行探讨,对干细胞的实施和目前正在进行的实验进行综述。
如何實現人類心肌的再生,科研工作者和臨床醫生已經為之努力瞭近一箇世紀。1953年,實施瞭第一例室間隔缺損脩複手術,1967年第一例心髒移植成功,2002年骨髓來源的細胞首次移植到心肌內,使心肌的脩複取得重大進步。然而慢性心力衰竭仍是世界範圍內的難題。為什麽實現心肌的再生麵臨巨大的挑戰?要實現心肌的再生還有多遠?細胞移植技術近年已取得突飛猛進的進步,許多大型動物實驗結果帶來瞭曙光和挑戰。將對心肌再生的歷史和臨床研究進行探討,對榦細胞的實施和目前正在進行的實驗進行綜述。
여하실현인류심기적재생,과연공작자화림상의생이경위지노력료근일개세기。1953년,실시료제일례실간격결손수복수술,1967년제일례심장이식성공,2002년골수래원적세포수차이식도심기내,사심기적수복취득중대진보。연이만성심력쇠갈잉시세계범위내적난제。위십요실현심기적재생면림거대적도전?요실현심기적재생환유다원?세포이식기술근년이취득돌비맹진적진보,허다대형동물실험결과대래료서광화도전。장대심기재생적역사화림상연구진행탐토,대간세포적실시화목전정재진행적실험진행종술。
Regenerating the human heart is a challenge that has engaged researchers and clinicians around the globe for nearly a century. From the repair of the ifrst septal defect in 1953, followed by the ifrst successful heart transplant in 1967, and later to the ifrst infusion of bone marrow-derived cells to the human myocardium in 2002, signiifcant progress has been made in heart repair. However, chronic heart failure remains a leading pathological burden worldwide. Why has regenerating the human heart been such a challenge, and how close are we to achieve clinically relevant regeneration? Exciting progress has been made to establish cell transplantation techniques in recent years, and new preclinical studies in large animal models have shed light on the promises and challenges that lie ahead. In this review, we will discuss the history of cell therapy approaches and provide an overview of clinical trials using cell transplantation for heart regeneration. Focusing on the delivery of human stem cell derived cardiomyocytes, current experimental strategies in the ifeld will be discussed as well as their clinical translation potential.