CAJ | 학술논문

目的：探讨乌鸡白凤丸与阿立哌唑对女性精神分裂症患者服用利培酮所致高催乳素血症的影响及其安全性。方法将应用利培酮治疗导致高催乳素血症的67例女性精神分裂症患者随机分为乌鸡白凤丸组和阿立哌唑组，疗程4周。结果乌鸡白凤丸组完成28例，阿立哌唑组完成30例，乌鸡白凤丸组血清催乳素明显低于入组前（t=7.624，P=0.000），阿立哌唑组血清催乳素明显低于入组前（t=8.278，P=0.000），两组血清催乳素水平无明显差异（t=1.965，P=0.054）。结论乌鸡白凤丸与阿立哌唑均能降低利培酮所致高催乳素水平，安全性好。
목적：탐토오계백봉환여아립고서대녀성정신분렬증환자복용리배동소치고최유소혈증적영향급기안전성。방법장응용리배동치료도치고최유소혈증적67례녀성정신분렬증환자수궤분위오계백봉환조화아립고서조，료정4주。결과오계백봉환조완성28례，아립고서조완성30례，오계백봉환조혈청최유소명현저우입조전（t=7.624，P=0.000），아립고서조혈청최유소명현저우입조전（t=8.278，P=0.000），량조혈청최유소수평무명현차이（t=1.965，P=0.054）。결론오계백봉환여아립고서균능강저리배동소치고최유소수평，안전성호。
Objective To explore the efifcacy and safety of Wujibaifeng pills and aripiprazole in the treatment of female hyperprolactinemia caused by risperidone.Methods 67 female schizophrenia patients with hyperprolactinemia caused by risperidone and aripiprazole were randomly assigned into Wujibaifeng pills group and aripiprazole group treated for 4 weeks. Results In Wujibaifeng pills group 28 cases were completed the treatment,in aripiprazole group 30 cases completed. In Wujibaifeng pills group, the serum prolactin was significantly lower than before treatment (t=7.624,P=0.000), serum prolactin in aripiprazole group was signiifcantly lower than that before treatment (t=8.278,P=0.000). The serum prolactin levels in the two groups had no significant difference (t=1.965,P=0.054) .Conclusion Wujibaifeng pills and aripiprazole can reduce risperidone induced hyperprolactinemia level with good safety.