CAJ | 학술논문

目的：检测胃癌组织中血管内皮生长因子(VEGF)-C、VEGF-D及其受体(VEGFR)-3的表达，探讨淋巴管新生与胃癌淋巴道转移的关系。方法应用免疫组织化学方法检测108例胃癌患者(伴淋巴结转移76例，无淋巴结转移32例)癌组织及癌旁组织中VEGF-C、VEGF-D和VEGFR-3的表达。结果胃癌组织中VEGF-C和VEGF-D检测阳性率均明显高于癌旁组织，且二者表达在有、无淋巴结转移组中比较差异有统计学意义(P<0.05)；VEGF-C、VEGF-D和VEGFR-3之间的表达具有关联。结论 VEGF-C、VEGF-D和VEGFR-3可能在胃癌淋巴结转移中起促进作用，联合检测三者表达可能有助于预测胃癌淋巴道转移情况。
목적：검측위암조직중혈관내피생장인자(VEGF)-C、VEGF-D급기수체(VEGFR)-3적표체，탐토림파관신생여위암림파도전이적관계。방법응용면역조직화학방법검측108례위암환자(반림파결전이76례，무림파결전이32례)암조직급암방조직중VEGF-C、VEGF-D화VEGFR-3적표체。결과위암조직중VEGF-C화VEGF-D검측양성솔균명현고우암방조직，차이자표체재유、무림파결전이조중비교차이유통계학의의(P<0.05)；VEGF-C、VEGF-D화VEGFR-3지간적표체구유관련。결론 VEGF-C、VEGF-D화VEGFR-3가능재위암림파결전이중기촉진작용，연합검측삼자표체가능유조우예측위암림파도전이정황。
Objective To study the relationship between lymphangiogenesis and lymph node metastasis of gastric carcinoma by detecting the expression of vascular endothelial growth factor (VEGF)-C, VEGF-D and their recep-tor-3 (VEGFR-3) in patients with gastric carcinoma. Methods Paraffin-embedded specimens from 108 patients with gastric carcinoma (including 76 patients with lymph node metastasis and 32 patients without node metastasis) were used to evaluate the expression of VEGF-C, VEGF-D, and VEGFR-3 by S-P immunohistochemical staining. Results The expression of VEGF-C and VEGF-D was significantly higher in specimens of gastric carcinoma than that of the corre-sponding adjacent peritumoral tissues. And there was statistically significant difference between the group with lymph node metastasis and the group without lymph node metastasis (P<0.05). Positive correlation was found among the ex-pression of VEGF-C, VEGF-D and VEGFR-3 in gastric carcinomas. Conclusion VEGF-C, VEGF-D and VEGFR-3 may promote the lymphatic metastasis of gastric carcinoma. Combined detection of these three markers in biopsy spec-imens of gastric carcinoma may be helpful in predicting the lymphatic metastasis.