目的 探讨马来酸噻吗洛尔滴眼液治疗婴幼儿表浅血管瘤的临床效果.方法 选取2012年4月至2014年5月符合纳入标准的婴幼儿表浅血管瘤病例210例,根据家属自愿的原则分为治疗组176例,等待观察的对照组34例.用无菌纱布蘸取马来酸噻吗洛尔滴眼液并覆盖于瘤体表面(药液浸透纱布的范围应大于或等于瘤体表面范围),每日用药3～4次,作用时间＞20 min,随诊期限为3周、6个月,以清晰图片的方式记录瘤体治疗情况.治疗效果评定分为4级:Ⅰ级,无法控制瘤体生长;Ⅱ级,瘤体生长停滞;Ⅲ级,瘤体较前明显消退;Ⅳ级,瘤体外观完全消失.统计有效率(治疗效果达Ⅲ级以上病例数占总数的百分比)和治愈率(治疗效果达Ⅳ级的病例占总数的百分比).应用SPSS 17.0统计软件进行数据处理和分析,分类变量采取卡方检验,P＜0.05为有统计学意义.结果 治疗组中有3例患儿瘤体周围出现湿疹样反应,1例患儿出现瘤体溃烂,不良反应发生率占2.3％.3月时随访,治疗组中154例瘤体生长停滞,颜色较前变暗,质地变软,厚度变薄;对照组中仅4例病例瘤体出现消退,18例瘤体较前颜色鲜艳,12例瘤体大小维持原状.6个月随访,治疗组中18例达到Ⅳ级标准,84例达到Ⅲ级,60例达到Ⅱ级,14例瘤体较前变大,为Ⅰ级标准,治疗有效率达58.0％,治愈率为10.2％;对照组中4例达到Ⅲ级标准,13例达到Ⅱ级,17例瘤体继续发展,为Ⅰ级标准,治愈率为0,有效率为11.8％.对照组治愈率及有效率明显低于治疗组,差异具有统计学意义(P＜0.05).结论 应用马来酸噻吗洛尔滴眼液治疗婴幼儿表浅血管瘤,疗效较为确切,不良反应发生率低,安全性高,操作简便,可作为首选药物.
目的 探討馬來痠噻嗎洛爾滴眼液治療嬰幼兒錶淺血管瘤的臨床效果.方法 選取2012年4月至2014年5月符閤納入標準的嬰幼兒錶淺血管瘤病例210例,根據傢屬自願的原則分為治療組176例,等待觀察的對照組34例.用無菌紗佈蘸取馬來痠噻嗎洛爾滴眼液併覆蓋于瘤體錶麵(藥液浸透紗佈的範圍應大于或等于瘤體錶麵範圍),每日用藥3～4次,作用時間＞20 min,隨診期限為3週、6箇月,以清晰圖片的方式記錄瘤體治療情況.治療效果評定分為4級:Ⅰ級,無法控製瘤體生長;Ⅱ級,瘤體生長停滯;Ⅲ級,瘤體較前明顯消退;Ⅳ級,瘤體外觀完全消失.統計有效率(治療效果達Ⅲ級以上病例數佔總數的百分比)和治愈率(治療效果達Ⅳ級的病例佔總數的百分比).應用SPSS 17.0統計軟件進行數據處理和分析,分類變量採取卡方檢驗,P＜0.05為有統計學意義.結果 治療組中有3例患兒瘤體週圍齣現濕疹樣反應,1例患兒齣現瘤體潰爛,不良反應髮生率佔2.3％.3月時隨訪,治療組中154例瘤體生長停滯,顏色較前變暗,質地變軟,厚度變薄;對照組中僅4例病例瘤體齣現消退,18例瘤體較前顏色鮮豔,12例瘤體大小維持原狀.6箇月隨訪,治療組中18例達到Ⅳ級標準,84例達到Ⅲ級,60例達到Ⅱ級,14例瘤體較前變大,為Ⅰ級標準,治療有效率達58.0％,治愈率為10.2％;對照組中4例達到Ⅲ級標準,13例達到Ⅱ級,17例瘤體繼續髮展,為Ⅰ級標準,治愈率為0,有效率為11.8％.對照組治愈率及有效率明顯低于治療組,差異具有統計學意義(P＜0.05).結論 應用馬來痠噻嗎洛爾滴眼液治療嬰幼兒錶淺血管瘤,療效較為確切,不良反應髮生率低,安全性高,操作簡便,可作為首選藥物.
목적 탐토마래산새마락이적안액치료영유인표천혈관류적림상효과.방법 선취2012년4월지2014년5월부합납입표준적영유인표천혈관류병례210례,근거가속자원적원칙분위치료조176례,등대관찰적대조조34례.용무균사포잠취마래산새마락이적안액병복개우류체표면(약액침투사포적범위응대우혹등우류체표면범위),매일용약3～4차,작용시간＞20 min,수진기한위3주、6개월,이청석도편적방식기록류체치료정황.치료효과평정분위4급:Ⅰ급,무법공제류체생장;Ⅱ급,류체생장정체;Ⅲ급,류체교전명현소퇴;Ⅳ급,류체외관완전소실.통계유효솔(치료효과체Ⅲ급이상병례수점총수적백분비)화치유솔(치료효과체Ⅳ급적병례점총수적백분비).응용SPSS 17.0통계연건진행수거처리화분석,분류변량채취잡방검험,P＜0.05위유통계학의의.결과 치료조중유3례환인류체주위출현습진양반응,1례환인출현류체궤란,불량반응발생솔점2.3％.3월시수방,치료조중154례류체생장정체,안색교전변암,질지변연,후도변박;대조조중부4례병례류체출현소퇴,18례류체교전안색선염,12례류체대소유지원상.6개월수방,치료조중18례체도Ⅳ급표준,84례체도Ⅲ급,60례체도Ⅱ급,14례류체교전변대,위Ⅰ급표준,치료유효솔체58.0％,치유솔위10.2％;대조조중4례체도Ⅲ급표준,13례체도Ⅱ급,17례류체계속발전,위Ⅰ급표준,치유솔위0,유효솔위11.8％.대조조치유솔급유효솔명현저우치료조,차이구유통계학의의(P＜0.05).결론 응용마래산새마락이적안액치료영유인표천혈관류,료효교위학절,불량반응발생솔저,안전성고,조작간편,가작위수선약물.
Objective To discuss the clinical efficacy of Timolol Maleate Eye Drops in the treatment of superficial infantile hemangiomas.Methods From April 2012 to May 2014, 210 patients with superficial infantile hemangiomas were included.According to the parents' choice, a total of 176 cases were treated with Timolol Maleate Eye Drops as the treatment group, and the 34 cases who received the treatment of "wait and see" was included in the control group.In the treatment group, the gauzes were dipped into the eye drops and putted evenly on the surface of the hemangioma, 3-4 times daily and lasted for more than 20 minutes.The gauze should completely cover the surface of the tumor.The follow-up periods were 3 weeks and 6 months after treatment with the pictures to record the treatment effect.The therapeutic effect was graded as: grade Ⅰ (unable to control the growth of the hemangioma) , lⅡ (the growth of the hemangioma stagnated) , Ⅲ (hemangioma significantly subsided) , Ⅳ (the hemangioma completely disappeared).The effective rate included the cases with grade Ⅱ and above grade Ⅱ.The cure cases included the cases with grade Ⅳ.The data was analyzed with the statistical software SPSS 17.0 and the Chi-square test(P ＜ 0.05).Results 3 cases in the treatment group showed eczema action.Tumor ulcer happened in 1 case in treatment group.The side effect rate was 2.3％.The results at 3 weeks following in the treatment group showed that the growth of the hemangioma were stagnated in 154 cases.The color of hemangioma became darker in different degrees than before, and the texture of the hemangioma became soft in majority of children, and the thickness of hemangioma became thinner in some cases.However, only 4 cases showed the hemangiomas were subsided, 18 cases showed the color of the part of the hemangiomas were brighter than before, and 12 cases of the hemangiomas remained original state in the control group.The results of 6 weeks following the treatment showed that 18 patients in the treatment group reached the standard of the grade Ⅳ, 84 patients reached the standard of the grade Ⅲ, 60 patients achieved in the standard of grade Ⅱ , and only 14 patients showed the volume of hemangiomas were increased as grade Ⅰ.The effective rate was 58.0％ , and the cure rate was 10.2％ in treatment group.In control group, no children reached the standard of the grade Ⅳ, 4 cases reached the standard of grade Ⅲ , 13 cases who remained original state reached the standard of grade]] , and 17 cases showed the volume of hemangiomas continued to increase as grade Ⅰ.The effective rate was 11.8％ , and the cure rate was 0.By comparison, the effective rate and the cure rate in the control group were relatively lower than those in the treatment group (P ＜ 0.05).Conclusions The efficacy of Timolol Maleate Eye Drops in the treatment of superficial infantile hemangioma is exact, especially in the proliferative phase of the infantile hemangioma.It is safe and easy to perform with mild side effect.It should be selected as first-line treatment.
