CAJ | 학술논문

目的：观察及探讨腹腔镜手术对胃十二指肠溃疡穿孔患者术后机体应激及炎性状态的影响程度。方法选取手术治疗的76例胃十二指肠溃疡穿孔患者为研究对象，随机数字表法分组，分别为对照组（传统开腹手术组）38例和观察组（腹腔镜手术组）38例。分别检测及比较两组术前1 d 及术后1 d、3 d、7 d的血清机体应激激素及抑炎、促炎状态相关指标。结果观察组术后1 d、3 d、7 d 的血清 IL-2分别为（3．53±0．24）μg／mL、（3．25±0．22）μg／mL 及（4．37±0．33）μg／mL，其均高于对照组（F ＝5．876，P ＜0．05），而其他血清机体应激激素及抑炎、促炎状态相关指标均明显地低于对照组（均 P ＜0．05），两组术后评估结果差异均有统计学意义。结论腹腔镜手术对胃十二指肠溃疡穿孔患者术后机体应激及炎性状态的影响相对较小，说明此类手术导致的机体不良应激程度相对较小。
목적：관찰급탐토복강경수술대위십이지장궤양천공환자술후궤체응격급염성상태적영향정도。방법선취수술치료적76례위십이지장궤양천공환자위연구대상，수궤수자표법분조，분별위대조조（전통개복수술조）38례화관찰조（복강경수술조）38례。분별검측급비교량조술전1 d 급술후1 d、3 d、7 d적혈청궤체응격격소급억염、촉염상태상관지표。결과관찰조술후1 d、3 d、7 d 적혈청 IL-2분별위（3．53±0．24）μg／mL、（3．25±0．22）μg／mL 급（4．37±0．33）μg／mL，기균고우대조조（F ＝5．876，P ＜0．05），이기타혈청궤체응격격소급억염、촉염상태상관지표균명현지저우대조조（균 P ＜0．05），량조술후평고결과차이균유통계학의의。결론복강경수술대위십이지장궤양천공환자술후궤체응격급염성상태적영향상대교소，설명차류수술도치적궤체불량응격정도상대교소。
Objective To observe and investigate the influence degree of laparoscopic operation for the postoperative body stress and inflammatory state of patients with gastric and duodenal ulcer perforation.Methods 76 patients with gastric and duodenal ulcer perforation were selected as study subjects,and they were divided into control group(conventional open operation group)and observation group(laparoscopic operation group)according to the random number table,38 cases in each group.The serum body stress hormones and antiinflammatory,proinflammatory related indexes of the two groups at first day before operation and at first,third,seventh day after operation were respectively detected and compared.Results The serum IL -2 levels of the observation group at first,third and seventh day after operation were (3.53 ±0.24)μg/mL,(3.25 ±0.22)μg/mL and (4.37 ±0.33)μg/mL,which were higher than those of the control group(F =5.876,P <0.05),while other serum body stress hormones and antiin-flammatory,proinflammatory related indexes were all obviously lower than those of the control group (all P <0.05), there were significant differences between those postoperative evaluation results of the two groups.Conclusion The influence of laparoscopic operation for the postoperative body stress and inflammatory state of patients with gastric and duodenal ulcer perforation is relatively small,and it shows that the bad body stress degree caused by the operation is relatively smaller.