中国基层医药
中國基層醫藥
중국기층의약
Chinese Journal of Primary Medicine and Pharmacy
2015年
23期
3636-3638
,共3页
肺炎%社区获得性感染%热毒宁注射液%哌拉西林钠/舒巴坦钠
肺炎%社區穫得性感染%熱毒寧註射液%哌拉西林鈉/舒巴坦鈉
폐염%사구획득성감염%열독저주사액%고랍서림납/서파탄납
Pneumonia%Community -acquired infections%Reduning injection%Piperacillin sodium and sulbactam sodium
目的：观察热毒宁注射液联合哌拉西林钠／舒巴坦钠治疗社区获得性肺炎（CAP）的临床疗效及安全性。方法将临床确诊为 CAP 的122例患者按数字表法随机分为治疗组和对照组，两组分别常规使用哌拉西林钠／舒巴坦钠3．75 g，每12小时一次，疗程7～10 d，治疗组加用热毒宁注射液，20 mL／d，疗程7～10 d，观察两组治疗前后的临床症状症状缓解时间、白细胞总数（WBC）及 CRP 恢复正常时间。结果治疗组有效率为94．91％，对照组为80．00％，两组差异有统计学意义（χ2＝10．286，P ＜0.05）；治疗组在控制发热、咳嗽症状缓解时间方面明显短于对照组（均 P ＜0．05）；两组治疗后3个月内 WBC 及 CRP 恢复正常率比较差异有统计学意义（χ2＝2．880，3．926，均 P ＜0．05）；两组均未见明显的毒副作用与不良反应。结论热毒宁注射液联合哌拉西林钠／舒巴坦钠治疗 CAP 可协同退热、缓解临床症状症状，临床疗效及安全性好，可作为 CAP 的有效治疗方法之一。
目的：觀察熱毒寧註射液聯閤哌拉西林鈉／舒巴坦鈉治療社區穫得性肺炎（CAP）的臨床療效及安全性。方法將臨床確診為 CAP 的122例患者按數字錶法隨機分為治療組和對照組，兩組分彆常規使用哌拉西林鈉／舒巴坦鈉3．75 g，每12小時一次，療程7～10 d，治療組加用熱毒寧註射液，20 mL／d，療程7～10 d，觀察兩組治療前後的臨床癥狀癥狀緩解時間、白細胞總數（WBC）及 CRP 恢複正常時間。結果治療組有效率為94．91％，對照組為80．00％，兩組差異有統計學意義（χ2＝10．286，P ＜0.05）；治療組在控製髮熱、咳嗽癥狀緩解時間方麵明顯短于對照組（均 P ＜0．05）；兩組治療後3箇月內 WBC 及 CRP 恢複正常率比較差異有統計學意義（χ2＝2．880，3．926，均 P ＜0．05）；兩組均未見明顯的毒副作用與不良反應。結論熱毒寧註射液聯閤哌拉西林鈉／舒巴坦鈉治療 CAP 可協同退熱、緩解臨床癥狀癥狀，臨床療效及安全性好，可作為 CAP 的有效治療方法之一。
목적：관찰열독저주사액연합고랍서림납／서파탄납치료사구획득성폐염（CAP）적림상료효급안전성。방법장림상학진위 CAP 적122례환자안수자표법수궤분위치료조화대조조，량조분별상규사용고랍서림납／서파탄납3．75 g，매12소시일차，료정7～10 d，치료조가용열독저주사액，20 mL／d，료정7～10 d，관찰량조치료전후적림상증상증상완해시간、백세포총수（WBC）급 CRP 회복정상시간。결과치료조유효솔위94．91％，대조조위80．00％，량조차이유통계학의의（χ2＝10．286，P ＜0.05）；치료조재공제발열、해수증상완해시간방면명현단우대조조（균 P ＜0．05）；량조치료후3개월내 WBC 급 CRP 회복정상솔비교차이유통계학의의（χ2＝2．880，3．926，균 P ＜0．05）；량조균미견명현적독부작용여불량반응。결론열독저주사액연합고랍서림납／서파탄납치료 CAP 가협동퇴열、완해림상증상증상，림상료효급안전성호，가작위 CAP 적유효치료방법지일。
Objective To observe the clinical efficacy and safety of Reduning injection combined with pip-eracillin sulbactam in the treatment of community acquired pneumonia(CAP).Methods 122 cases with CAP were randomly divided into treatment group and control group by digital table method.The two groups were given piperacil-lin sodium and sulbactam sodium 3.75g,once every 12 hours,course 7 -10d.The treatment group was treated with Reduning injection,20ml/d treatment for 7 -10d.The clinical symptoms of the two groups before and after treatment, the total number of white blood cells(WBC)and C reactive protein(CRP)to resume normal time were observed. Results The effective rate was 94.91% in the treatment group and 80% in the control group,the difference between the two groups was statistically significant(χ2 =10.286,P <0.05).The treatment group was significantly shorter than the control group in controlling fever and cough symptoms(all P <0.05).3 months after treatment,the WBC and CRP recovery to the normal rate of the two groups had statistically significant differences (χ2 =2.880,3.926,all P <0.05).No obvious toxic side effects and adverse reactions were observed in the two groups.Conclusion Reduning injection combined with piperacillin sodium and sulbactam sodium in the treatment of CAP can alleviate the clinical symptoms of fever.This method has good clinical curative effect and high safety.It can be used as an effective method for treatment of CAP.
