国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
International Journal of Respiration
2015年
20期
1550-1553
,共4页
可溶性髓样细胞触发受体-1%慢性阻塞性肺疾病%肺炎
可溶性髓樣細胞觸髮受體-1%慢性阻塞性肺疾病%肺炎
가용성수양세포촉발수체-1%만성조새성폐질병%폐염
Soluble triggering receptor expressed on myeliod cells-1%Chronic obstructive pulmonary disease%Pneumonia
目的 探讨可溶性髓样细胞触发受体-1(soluble triggering receptor expressed on myeliod cells-1,sTREM-1)在慢性阻塞性肺疾病急性加重期(AECOPD)合并肺炎患者诊断中的应用价值.方法 选取AECOPD患者106例,根据痰菌培养结果将患者分为A组(合并肺炎,56例)和B组(非合并肺炎,50例),全部研究对象采用双抗体夹心酶联免疫吸附法测定痰液和血清sTREM-1水平,组间比较sTREM-1水平的差异.结果 入院第1天、第4天和第7天,A组患者痰液和血清sTREM-1水平明显高于B组,组间比较差异有统计学意义(t=7.13,8.21,4.21,5.14,3.98,4.01,P＜0.05),入院第4天和第7天上述指标明显低于入院第1天,比较差异有统计学意义(t=6.01,7.11,5.87,6.02,P＜0.05);经ROC曲线分析发现,痰液和血清sTREM-1单项、联合检测对AECOPD合并肺炎预测的ROC曲线下面积为0.795、0.814、0.925,联合检测预测价值明显优于单项检测(t =3.56,3.14,P＜0.05),当痰液sTREM-1=56.98 ng/L、血清sTREM-1=103 μg/L,诊断灵敏度为86.27％、89.62％,特异度为83.14％、85.06％,两者比较差异无统计学意义(P＞0.05).结论 痰液、血清sTREM-1联合检测对AECOPD合并肺炎诊断具有重要的价值.
目的 探討可溶性髓樣細胞觸髮受體-1(soluble triggering receptor expressed on myeliod cells-1,sTREM-1)在慢性阻塞性肺疾病急性加重期(AECOPD)閤併肺炎患者診斷中的應用價值.方法 選取AECOPD患者106例,根據痰菌培養結果將患者分為A組(閤併肺炎,56例)和B組(非閤併肺炎,50例),全部研究對象採用雙抗體夾心酶聯免疫吸附法測定痰液和血清sTREM-1水平,組間比較sTREM-1水平的差異.結果 入院第1天、第4天和第7天,A組患者痰液和血清sTREM-1水平明顯高于B組,組間比較差異有統計學意義(t=7.13,8.21,4.21,5.14,3.98,4.01,P＜0.05),入院第4天和第7天上述指標明顯低于入院第1天,比較差異有統計學意義(t=6.01,7.11,5.87,6.02,P＜0.05);經ROC麯線分析髮現,痰液和血清sTREM-1單項、聯閤檢測對AECOPD閤併肺炎預測的ROC麯線下麵積為0.795、0.814、0.925,聯閤檢測預測價值明顯優于單項檢測(t =3.56,3.14,P＜0.05),噹痰液sTREM-1=56.98 ng/L、血清sTREM-1=103 μg/L,診斷靈敏度為86.27％、89.62％,特異度為83.14％、85.06％,兩者比較差異無統計學意義(P＞0.05).結論 痰液、血清sTREM-1聯閤檢測對AECOPD閤併肺炎診斷具有重要的價值.
목적 탐토가용성수양세포촉발수체-1(soluble triggering receptor expressed on myeliod cells-1,sTREM-1)재만성조새성폐질병급성가중기(AECOPD)합병폐염환자진단중적응용개치.방법 선취AECOPD환자106례,근거담균배양결과장환자분위A조(합병폐염,56례)화B조(비합병폐염,50례),전부연구대상채용쌍항체협심매련면역흡부법측정담액화혈청sTREM-1수평,조간비교sTREM-1수평적차이.결과 입원제1천、제4천화제7천,A조환자담액화혈청sTREM-1수평명현고우B조,조간비교차이유통계학의의(t=7.13,8.21,4.21,5.14,3.98,4.01,P＜0.05),입원제4천화제7천상술지표명현저우입원제1천,비교차이유통계학의의(t=6.01,7.11,5.87,6.02,P＜0.05);경ROC곡선분석발현,담액화혈청sTREM-1단항、연합검측대AECOPD합병폐염예측적ROC곡선하면적위0.795、0.814、0.925,연합검측예측개치명현우우단항검측(t =3.56,3.14,P＜0.05),당담액sTREM-1=56.98 ng/L、혈청sTREM-1=103 μg/L,진단령민도위86.27％、89.62％,특이도위83.14％、85.06％,량자비교차이무통계학의의(P＞0.05).결론 담액、혈청sTREM-1연합검측대AECOPD합병폐염진단구유중요적개치.
Objective To investigate the diagnosis value of soluble triggering receptor expressed on myeliod cells-1 (sTREM-1) levels in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined pneumonia.Methods One hundred and six cases of AECOPD were selected,according to sputum bacteria culture results, all were divided into group A (56 cases of pneumonia,) and group B (50 cases of non pneumonia), sputum, serum sTREM-1 level were determination by double antibody sandwich enzyme linked immunosorbent assay,differences of sTREM-1 levels between groups were compared.Results The 1,4,7 day of admission,sputum and serum sTREM-1 levels of A group were significantly higher than B group,it had statistical significance between groups (t =7.13,8.21,4.21,5.14,3.98,4.01, P ＜ 0.05), on the 4,7 day of admission, the index were significantly lower than the first day of admission (t =6.01,7.11,5.87,6.02, P ＜0.05), ROC curve analysis found,area of under ROC curve of sputum and serum sTREM-1 individual or combined detection on AECOPD prediction with pneumonia were 0.795,0.814,0.925, the predictive value of combined detection is better than the individual detection (t =3.56,3.14, P ＜0.05), while the sputum sTREM-1 =56.98 ng/L,serum sTREM-1 =103 μg/L, the diagnostic sensitivity were 86.27％, 89.62％, the specificity were 83.14％ ,85.06％ (P ＞0.05).Conclusions Sputum and serum sTREM-1 combined detection has an important value in the diagnosis of AECOPD with pneumonia.
