中国基层医药
中國基層醫藥
중국기층의약
Chinese Journal of Primary Medicine and Pharmacy
2015年
23期
3552-3554
,共3页
吴仙丹%张近波%许国斌%董美平%朱金强%鄢来超%曹烈祥
吳仙丹%張近波%許國斌%董美平%硃金彊%鄢來超%曹烈祥
오선단%장근파%허국빈%동미평%주금강%언래초%조렬상
胰腺炎%高脂血症%肾替代疗法
胰腺炎%高脂血癥%腎替代療法
이선염%고지혈증%신체대요법
Pancreatitis%Hyperlipoidemia%Renal replacement therapy(CRRT)
目的:探讨早期连续性肾替代治疗(CRRT)对高脂血症性重症急性胰腺炎疗效及预后的影响。方法将32例高脂血症性重症急性胰腺炎患者按照平行对照设计原理分为对照组15例和 CRRT 组17例,对照组行常规治疗,CRRT 组在常规治疗基础上行 CRRT 治疗。对两组患者的 APACHEⅡ评分,甘油三酯(TG),血、尿淀粉酶(AMS)水平,机械通气人数进行比较。结果与对照组比较,CRRT 组第3天 TG 水平[(18.36±3.28)mmol/L 比(5.13±1.52)mmol/L]均明显降低(t =2.885,P =0.003);与对照组比较,治疗后CRRT 组机械通气发生率(66.67%比29.41%)、APACHEⅡ评分[(21.68±4.95)分比(14.68±5.03)分]、病死率(46.67%比11.76%)明显降低(χ2=4.441,t =4.601,χ2=4.802;P =0.035,0.032,0.028)。与对照组患者比较,CRRT 组患者治疗前年龄、性别、APACHE Ⅱ评分等两组差异无统计学意义(均 P >0.05);与对照组患者比较,CRRT 组患者第3天血、尿淀粉酶(AMS)水平差异无统计学意义(均 P >0.05)。结论早期 CRRT可以快速降低 HLSAP 患者血 TG 水平,改善 HLSAP 患者预后。
目的:探討早期連續性腎替代治療(CRRT)對高脂血癥性重癥急性胰腺炎療效及預後的影響。方法將32例高脂血癥性重癥急性胰腺炎患者按照平行對照設計原理分為對照組15例和 CRRT 組17例,對照組行常規治療,CRRT 組在常規治療基礎上行 CRRT 治療。對兩組患者的 APACHEⅡ評分,甘油三酯(TG),血、尿澱粉酶(AMS)水平,機械通氣人數進行比較。結果與對照組比較,CRRT 組第3天 TG 水平[(18.36±3.28)mmol/L 比(5.13±1.52)mmol/L]均明顯降低(t =2.885,P =0.003);與對照組比較,治療後CRRT 組機械通氣髮生率(66.67%比29.41%)、APACHEⅡ評分[(21.68±4.95)分比(14.68±5.03)分]、病死率(46.67%比11.76%)明顯降低(χ2=4.441,t =4.601,χ2=4.802;P =0.035,0.032,0.028)。與對照組患者比較,CRRT 組患者治療前年齡、性彆、APACHE Ⅱ評分等兩組差異無統計學意義(均 P >0.05);與對照組患者比較,CRRT 組患者第3天血、尿澱粉酶(AMS)水平差異無統計學意義(均 P >0.05)。結論早期 CRRT可以快速降低 HLSAP 患者血 TG 水平,改善 HLSAP 患者預後。
목적:탐토조기련속성신체대치료(CRRT)대고지혈증성중증급성이선염료효급예후적영향。방법장32례고지혈증성중증급성이선염환자안조평행대조설계원리분위대조조15례화 CRRT 조17례,대조조행상규치료,CRRT 조재상규치료기출상행 CRRT 치료。대량조환자적 APACHEⅡ평분,감유삼지(TG),혈、뇨정분매(AMS)수평,궤계통기인수진행비교。결과여대조조비교,CRRT 조제3천 TG 수평[(18.36±3.28)mmol/L 비(5.13±1.52)mmol/L]균명현강저(t =2.885,P =0.003);여대조조비교,치료후CRRT 조궤계통기발생솔(66.67%비29.41%)、APACHEⅡ평분[(21.68±4.95)분비(14.68±5.03)분]、병사솔(46.67%비11.76%)명현강저(χ2=4.441,t =4.601,χ2=4.802;P =0.035,0.032,0.028)。여대조조환자비교,CRRT 조환자치료전년령、성별、APACHE Ⅱ평분등량조차이무통계학의의(균 P >0.05);여대조조환자비교,CRRT 조환자제3천혈、뇨정분매(AMS)수평차이무통계학의의(균 P >0.05)。결론조기 CRRT가이쾌속강저 HLSAP 환자혈 TG 수평,개선 HLSAP 환자예후。
Objective To investigate the effects of early continuous renal replacement thempy(CRRT)for hyperlipoidemia severe acute pancreatitis (HLSAP)patients.Methods 32 HLSAP patients were randomly divided into control group and CRRT treatment group.The levels of serum triglyceride(TG),serum and urine amylase,the APACHEⅡscore,the incidence of mechanical ventilation were compared between the two groups.Results The levels of serum TG was significantly lower in CRRT group than that in the control group in day 3(t =2.885,P =0.003). The APACHE II score,incidence rate of mechanical ventilation,the fatality rate were significantly lower in CRRT group than those in the control group in day 3(χ2 =4.572,t =4.912,χ2 =4.043;P =0.032,0.027,0.044).There were no significant differences between late group than that early group in age,gender,APACHE II score(all P >0.05).There were no significant differences between the two groups in the levels of amylase in serum and urine in day 3(all P >0.05).Conclusion Early CRRT therapy can eliminate the level of TG in HLSAP patients,may improve the prognosis of HLSAP patients.