中华老年心脑血管病杂志
中華老年心腦血管病雜誌
중화노년심뇌혈관병잡지
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2015年
11期
1160-1162
,共3页
王江友%陈涵%苏晞%李浪
王江友%陳涵%囌晞%李浪
왕강우%진함%소희%리랑
尿酸%心绞痛%支架%冠状血管造影术%冠状动脉再狭窄
尿痠%心絞痛%支架%冠狀血管造影術%冠狀動脈再狹窄
뇨산%심교통%지가%관상혈관조영술%관상동맥재협착
uric acid%angina pectoris%stents%coronary angiography%coronary restenosis
目的:探讨尿酸水平对稳定性心绞痛患者支架置入后发生支架内再狭窄的影响。方法136例稳定性心绞痛成功行支架置入治疗患者,根据术后12~18个月冠状动脉造影结果分为再狭窄组62例及对照组74例;对冠状动脉造影结果用计算机辅助的定量分析法评价。结果对照组尿酸水平明显低于再狭窄组[(364.21±42.47)μmol/L vs (440.66±69.05)μmol/L ,P=0.000];对照组术后12~18个月的最小管腔直径明显大于再狭窄组[(2.12±0.38)mm vs (0.76±0.37)mm ,P=0.013];狭窄程度术后12~18个月对照组明显低于再狭窄组[(35.84±12.34)% v s (84.53±14.26)%,P=0.000];对照组晚期管腔丢失明显小于再狭窄组[(0.27±0.14) mm vs (1.66±0.57)mm ,P=0.000]。尿酸与支架术后再狭窄有关(OR=0.680,95% CI:0.564~0.937,P<0.05)。结论尿酸水平增高可能是稳定性心绞痛患者支架置入后发生支架内再狭窄的原因之一。
目的:探討尿痠水平對穩定性心絞痛患者支架置入後髮生支架內再狹窄的影響。方法136例穩定性心絞痛成功行支架置入治療患者,根據術後12~18箇月冠狀動脈造影結果分為再狹窄組62例及對照組74例;對冠狀動脈造影結果用計算機輔助的定量分析法評價。結果對照組尿痠水平明顯低于再狹窄組[(364.21±42.47)μmol/L vs (440.66±69.05)μmol/L ,P=0.000];對照組術後12~18箇月的最小管腔直徑明顯大于再狹窄組[(2.12±0.38)mm vs (0.76±0.37)mm ,P=0.013];狹窄程度術後12~18箇月對照組明顯低于再狹窄組[(35.84±12.34)% v s (84.53±14.26)%,P=0.000];對照組晚期管腔丟失明顯小于再狹窄組[(0.27±0.14) mm vs (1.66±0.57)mm ,P=0.000]。尿痠與支架術後再狹窄有關(OR=0.680,95% CI:0.564~0.937,P<0.05)。結論尿痠水平增高可能是穩定性心絞痛患者支架置入後髮生支架內再狹窄的原因之一。
목적:탐토뇨산수평대은정성심교통환자지가치입후발생지가내재협착적영향。방법136례은정성심교통성공행지가치입치료환자,근거술후12~18개월관상동맥조영결과분위재협착조62례급대조조74례;대관상동맥조영결과용계산궤보조적정량분석법평개。결과대조조뇨산수평명현저우재협착조[(364.21±42.47)μmol/L vs (440.66±69.05)μmol/L ,P=0.000];대조조술후12~18개월적최소관강직경명현대우재협착조[(2.12±0.38)mm vs (0.76±0.37)mm ,P=0.013];협착정도술후12~18개월대조조명현저우재협착조[(35.84±12.34)% v s (84.53±14.26)%,P=0.000];대조조만기관강주실명현소우재협착조[(0.27±0.14) mm vs (1.66±0.57)mm ,P=0.000]。뇨산여지가술후재협착유관(OR=0.680,95% CI:0.564~0.937,P<0.05)。결론뇨산수평증고가능시은정성심교통환자지가치입후발생지가내재협착적원인지일。
Objective To study the effect of serum uric acid (UA ) level on coronary artery instent restenosis in patients with SAP .Methods One hundred and thirty‐six SAP patients 12 -18 months after stenting were divided into restenosis group (n=62) with their restenosis ≥50% and control group (n=74)with their restenosis <50% .Results The serum UA level was significant‐ly lower in control group than in restenosis group (364 .21 ± 42 .47 μmol/L vs 440 .66 ± 69 .05μmol/L ,P=0 .000) .The MLD was significantly longer ,the incidence of stenosis was significantly lower ,and the advanced lumen diameter was significantly shorter in control group than in resteno‐sis group 12-18 momths after stgenting (2 .12 ± 0 .38 mm vs 0 .76 ± 0 .37 mm ,P= 0 .013 ;35.84% ±12.34% vs84.53% ±14.26% ,P= 0.000;0.27±0.14mm vs1.66±0.57mm,P=0.000) .Multivariate logistic regression analysis showed that serum UA level was associated with restenosis after stenting (OR=0 .680 ,95% CI:0 .564-0.937 ,P<0 .05) .Conclusion Elevated se‐rum UA level is one of the mechanisms for restenosis in SAP patients after stenting .