CAJ | 학술논문

目的定量研究面肌痉挛患者及健康人后颅窝有效空间大小,探索后颅窝容积缩小与面肌痉挛发生之间的相关性.方法共纳入2013年5月至2014年6月就诊于四川大学华西医院神经外科的60例诊断明确的面肌痉挛患者,60名对照为性别、年龄配对的健康人.两组均行头部三维薄层磁共振检查,利用容积测量软件3 D-slicer分别测量两组后颅窝脑组织和骨性空间大小.结果面肌痉挛患者组后颅窝拥挤指数为83.7％±0.6％;健康对照组后颅窝拥挤指数为79.2％±0.4％,两组差异有统计学意义(t=2.58,P=0.01).多元线性回归分析提示较高的后颅窝拥挤指数与较小的年龄(r=-0.61,P=0.02)、女性(r=0.76,P=0.003)及面肌痉挛患者(r=-0.43,P=0.01)相关.结论面肌痉挛患者后颅窝较健康对照组更加拥挤,后颅窝空间狭小可能与"神经血管冲突"的发生相关,进而更容易导致面肌痉挛.女性较男性的后颅窝更加拥挤,这可能部分解释了面肌痉挛中女性高发的原因.
목적 정량연구면기경련환자급건강인후로와유효공간대소,탐색후로와용적축소여면기경련발생지간적상관성.방법 공납입2013년5월지2014년6월취진우사천대학화서의원신경외과적60례진단명학적면기경련환자,60명대조위성별、년령배대적건강인.량조균행두부삼유박층자공진검사,이용용적측량연건3 D-slicer분별측량량조후로와뇌조직화골성공간대소.결과 면기경련환자조후로와옹제지수위83.7％±0.6％;건강대조조후로와옹제지수위79.2％±0.4％,량조차이유통계학의의(t=2.58,P=0.01).다원선성회귀분석제시교고적후로와옹제지수여교소적년령(r=-0.61,P=0.02)、녀성(r=0.76,P=0.003)급면기경련환자(r=-0.43,P=0.01)상관.결론 면기경련환자후로와교건강대조조경가옹제,후로와공간협소가능여"신경혈관충돌"적발생상관,진이경용역도치면기경련.녀성교남성적후로와경가옹제,저가능부분해석료면기경련중녀성고발적원인.
Objective To quantitatively study the posterior fossa effective space and its relationship with hemifacial spasm (HFS).Methods We conducted a case-control study of patients diagnosed with HFS and sex-and age-matched healthy controls.All subjects underwent high-resolution three-dimensional MRI.The software of 3D-Slicer was used to measure the posterior fossa space and hindbrain tissue volume between the two groups.Results Sixty patients and 60 controls were enrolled in this study.Compared to controls,patients with HFS had a higher posterior fossa crowdedness index (PFCI;83.7％ ± 0.6％ vs 79.2％ ± 0.4％;t =2.58, P =0.01).The multivariate linear regression analysis revealed that a higher PFCI was associated with younger age (r =-0.61, P =0.02), female gender (r =0.76, P =0.003) and HFS (r =-0.43, P =0.01).Conclusions Patients with HFS have a more crowded posterior fossa space than healthy controls, potentially leading to cranial nerve and vascular structure crowding, thus increasing HFS risk.Women have a higher PFCI, which may explain the strong female preponderance in epidemiologic studies.