中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2015年
11期
991-994
,共4页
张守字%张力%武海燕%马丽%李锐%李娟
張守字%張力%武海燕%馬麗%李銳%李娟
장수자%장력%무해연%마려%리예%리연
阿尔茨海默病%轻度认知障碍%神经网%磁共振成像
阿爾茨海默病%輕度認知障礙%神經網%磁共振成像
아이자해묵병%경도인지장애%신경망%자공진성상
Alzheimer's disease%Mild cognitive impairment%Nerve net%Magnetic resonance imaging
目的 采用功能磁共振(fMRI)技术,观察轻度阿尔茨海默病(AD)、遗忘型轻度认知功能障碍(aMCI)患者静息态脑自发活动变化,探讨fMRI成像标志物对诊断AD及aMCI的临床价值.方法 以临床诊断aMCI、诊断很可能AD患者和正常认知对照组各12例为研究对象,对其进行简易精神状态检查(MMSE)评分和静息态fMRI扫描,利用分数低频振幅(fA LFF)方法对静息态大脑自发活动进行对比分析,观察AD患者、aMCI患者相对于对照组在fALFF指标有显著差异的区域.结果 静息态fMRI结果显示,在楔前叶,AD组fALFF值(1.11±0.07)与对照组(1.24 ±0.11,t=2.89,P=0.012)和aMCI组(1.34±0.17,t=3.49,P=0.004)相比均显著下降,aMCI组fALFF值最高,但与对照组相比差异无统计学意义;在顶下小叶,AD组fALFF值(0.96±0.07)和对照组(1.11±0.07,t4.31,P =0.001)、aMCI组(1.09±0.08,t=3.44,P=0.004)相比均显著下降.结论 AD患者较aMCI患者及正常认知老年人脑内特定区域自发活动受损明显;aMCI患者脑内特定区域自发活动与对照组相比无显著改变,但在某些和高级神经功能密切相关的区域如楔前叶有代偿增强的倾向.
目的 採用功能磁共振(fMRI)技術,觀察輕度阿爾茨海默病(AD)、遺忘型輕度認知功能障礙(aMCI)患者靜息態腦自髮活動變化,探討fMRI成像標誌物對診斷AD及aMCI的臨床價值.方法 以臨床診斷aMCI、診斷很可能AD患者和正常認知對照組各12例為研究對象,對其進行簡易精神狀態檢查(MMSE)評分和靜息態fMRI掃描,利用分數低頻振幅(fA LFF)方法對靜息態大腦自髮活動進行對比分析,觀察AD患者、aMCI患者相對于對照組在fALFF指標有顯著差異的區域.結果 靜息態fMRI結果顯示,在楔前葉,AD組fALFF值(1.11±0.07)與對照組(1.24 ±0.11,t=2.89,P=0.012)和aMCI組(1.34±0.17,t=3.49,P=0.004)相比均顯著下降,aMCI組fALFF值最高,但與對照組相比差異無統計學意義;在頂下小葉,AD組fALFF值(0.96±0.07)和對照組(1.11±0.07,t4.31,P =0.001)、aMCI組(1.09±0.08,t=3.44,P=0.004)相比均顯著下降.結論 AD患者較aMCI患者及正常認知老年人腦內特定區域自髮活動受損明顯;aMCI患者腦內特定區域自髮活動與對照組相比無顯著改變,但在某些和高級神經功能密切相關的區域如楔前葉有代償增彊的傾嚮.
목적 채용공능자공진(fMRI)기술,관찰경도아이자해묵병(AD)、유망형경도인지공능장애(aMCI)환자정식태뇌자발활동변화,탐토fMRI성상표지물대진단AD급aMCI적림상개치.방법 이림상진단aMCI、진단흔가능AD환자화정상인지대조조각12례위연구대상,대기진행간역정신상태검사(MMSE)평분화정식태fMRI소묘,이용분수저빈진폭(fA LFF)방법대정식태대뇌자발활동진행대비분석,관찰AD환자、aMCI환자상대우대조조재fALFF지표유현저차이적구역.결과 정식태fMRI결과현시,재설전협,AD조fALFF치(1.11±0.07)여대조조(1.24 ±0.11,t=2.89,P=0.012)화aMCI조(1.34±0.17,t=3.49,P=0.004)상비균현저하강,aMCI조fALFF치최고,단여대조조상비차이무통계학의의;재정하소협,AD조fALFF치(0.96±0.07)화대조조(1.11±0.07,t4.31,P =0.001)、aMCI조(1.09±0.08,t=3.44,P=0.004)상비균현저하강.결론 AD환자교aMCI환자급정상인지노년인뇌내특정구역자발활동수손명현;aMCI환자뇌내특정구역자발활동여대조조상비무현저개변,단재모사화고급신경공능밀절상관적구역여설전협유대상증강적경향.
Objective To investigate the functional changes of brain spontaneous activity in patients with Alzheimer' s disease (AD) and amnestic mild cognitive impairment (aMCI) using resting-state functional magnetic resonance imaging (fMR1), and evaluate the potential value of fMRI marker in clinical diagnosis of AD and aMCI.Methods Twelve AD patients, 12 aMCI patients and 12 normal controls (NC) were assessed by the Minimum Mental State Examination (MMSE) and scanned using the resting-state fMRI.The fractional amplitude of low-frequency fluctuations (fALFF) method was employed to examine the changes of the brain spontaneous activity among the three groups.Results Significant between-group differences were found in the precuneus and the inferior parietal lobe.In the precuneus, the fALFF value in AD patients (mean ± SD : 1.11 ± 0.07) was significantly decreased as compared to NC (1.24 ± 0.11, t =2.89,P =0.012) and aMCI patients (1.34 ±0.17,t =3.49,P =0.004).The aMCI patients demonstrated numerically largest fALFF in the precuneus.In the inferior parietal lobe, the fALFF values in AD patients (0.96 ±0.07) were also significantly decreased as compared to NC (1.11 ±0.07 ,t =4.31 ,P =0.001) and aMCI patients (1.09 ± 0.08, t =3.44, P =0.004).Conclusions AD patients were mostly influenced in the specific regions in terms of brain spontaneous activity, while the aMCI patients showed a compensatory tendency in the precuneus.
