CAJ | 학술논문

目的：调查贵州省福泉县脑卒中高危人群氧化应激指标与颈动脉粥样硬化（CAS ）关系，分析CAS相关危险因素。方法采用随机整群抽样法对福泉县6个镇、4个乡常住居民9500例进行健康问卷调查、体格检查、实验室检查、心电图检查及颈动脉彩色超声检查。共筛选出脑卒中高危人群1032例，随机选取高危人群360例，再根据颈部血管彩色超声筛查结果分为颈动脉正常组78例、颈动脉内膜中层厚度（IM T ）增厚组131例及CAS组151例，检测氧化应激指标氧化型低密度脂蛋白（ox‐LDL）及超氧化物歧化酶（SOD）变化，采用单因素和多因素logistic回归分析CAS的危险因素。结果 CAS组ox‐LDL明显高于颈动脉正常组和IMT 增厚组[（564．7±70．6）μg／L vs （434．5±46．3）μg／L ，（488．1±51．2）μg／L ，P＜0．05]，SOD明显低于颈动脉正常组和IM T增厚组[（41．0±18．1） kU／L vs （67．4±9．5）kU／L ，（58．6±10．3）kU／L ，P＜0．05]。logistic回归分析显示，年龄、吸烟、高血压、脑卒中史或家族史、空腹血糖、LDL‐C、ox‐LDL升高是导致CAS的独立危险因素。结论加强脑卒中高危人群管理，积极指导控制各项危险因素，调控患者氧化应激反应，可延缓CAS ，降低脑卒中发生。
목적：조사귀주성복천현뇌졸중고위인군양화응격지표여경동맥죽양경화（CAS ）관계，분석CAS상관위험인소。방법채용수궤정군추양법대복천현6개진、4개향상주거민9500례진행건강문권조사、체격검사、실험실검사、심전도검사급경동맥채색초성검사。공사선출뇌졸중고위인군1032례，수궤선취고위인군360례，재근거경부혈관채색초성사사결과분위경동맥정상조78례、경동맥내막중층후도（IM T ）증후조131례급CAS조151례，검측양화응격지표양화형저밀도지단백（ox‐LDL）급초양화물기화매（SOD）변화，채용단인소화다인소logistic회귀분석CAS적위험인소。결과 CAS조ox‐LDL명현고우경동맥정상조화IMT 증후조[（564．7±70．6）μg／L vs （434．5±46．3）μg／L ，（488．1±51．2）μg／L ，P＜0．05]，SOD명현저우경동맥정상조화IM T증후조[（41．0±18．1） kU／L vs （67．4±9．5）kU／L ，（58．6±10．3）kU／L ，P＜0．05]。logistic회귀분석현시，년령、흡연、고혈압、뇌졸중사혹가족사、공복혈당、LDL‐C、ox‐LDL승고시도치CAS적독립위험인소。결론가강뇌졸중고위인군관리，적겁지도공제각항위험인소，조공환자양화응격반응，가연완CAS ，강저뇌졸중발생。
Objective To analyze the risk factors for CAS by investigating the relation between oxi‐dative stress and CAS in population at high risk of ischemic stroke in Fuquan County of Guizhou Province .Methods One thousand and thirty two individuals at high risk of ischemic stroke were screened from 9500 permanent residents of Fuquan County by questionarie investigation ,physical examination ,laboratory test ,ECG and neck vascular color ultrasonography .Three hundred and sixty randomly selected from the 1032 individuals were divided into normal carotid artery group (n=78) ,thickened carotid IM T group (n=131) and CAS group (n=151) .Their serum ox‐LDL and SOD levels were measured and the risk factors for their CAS were analyzed by univariate and multivariate logistic regression analysis respectively .Results The serum ox‐LDL level was signif‐icantly higher while the serum SOD level was significantly lower in CAS group than in normal ca‐rotid artery group and thickened carotid IM T group (P<0 .05) .Univariate and multivariate logis‐tic regression analysis showed that age ,smoking ,hypertension ,history of ischemic stroke ,and ele‐vated serum FPG ,LDL‐C ,ox‐LDL levels were the independent risk factors for CAS .Conclusion Good management of population at high risk of ischemic stroke ,active control of risk factors for CAS and oxidative stress can delay the progression of CAS and reduce the incidence of ischemic stroke .