功能与分子医学影像学杂志（电子版）
功能與分子醫學影像學雜誌（電子版）
공능여분자의학영상학잡지（전자판）
Functional and Molecular Medical Imaging(Electronic Edition)
2015年
3期
696-701
,共6页
常晓腾%陈自谦%席继辉%王蕾%王晓阳
常曉騰%陳自謙%席繼輝%王蕾%王曉暘
상효등%진자겸%석계휘%왕뢰%왕효양
颞叶癫痫%语言功能%动词生成任务%功能磁共振
顳葉癲癇%語言功能%動詞生成任務%功能磁共振
섭협전간%어언공능%동사생성임무%공능자공진
temporal lobe epilepsy%language function%verbal generation task%fMRI
目的 利用Bold-fMRI研究颞叶癫痫(TLE)患者与正常对照组在语言任务模式下脑激活的差异,探讨颞叶癫痫患者脑语言功能改变的影像学表现.方法 对经过手术病理证实的17例发作间期右利手TLE患者及相匹配14例正常对照者行动词生成语言任务的脑部Bold-fMRI检查.采用SPM 8软件对Bold-fMRI脑功能图像进行数据处理和分析,采用两样本t检验比较癫痫组和对照组动词生成语言任务的fMRI激活图差异.结果 Bold-fMRI脑激活结果显示,左侧颞叶癫痫组与对照组比较脑功能激活减低的区域有双侧额下回、颞下回、双侧枕叶、双侧小脑半球、双侧岛叶、前扣带回、双侧中央前回、辅助运动区及左侧海马、舌回,激活增高的区域为右侧楔前叶;右侧颞叶癫痫组与对照组比较,脑功能激活减低的区域有右侧额下回、中央后回及岛叶.说明左侧颞叶癫痫对语言相关功能区的影响较大.结论 颞叶癫痫患者动词生成任务Bold-fMRI脑功能激活范围及强度较健康对照组明显降低,以左侧颞叶癫痫者为著.
目的 利用Bold-fMRI研究顳葉癲癇(TLE)患者與正常對照組在語言任務模式下腦激活的差異,探討顳葉癲癇患者腦語言功能改變的影像學錶現.方法 對經過手術病理證實的17例髮作間期右利手TLE患者及相匹配14例正常對照者行動詞生成語言任務的腦部Bold-fMRI檢查.採用SPM 8軟件對Bold-fMRI腦功能圖像進行數據處理和分析,採用兩樣本t檢驗比較癲癇組和對照組動詞生成語言任務的fMRI激活圖差異.結果 Bold-fMRI腦激活結果顯示,左側顳葉癲癇組與對照組比較腦功能激活減低的區域有雙側額下迴、顳下迴、雙側枕葉、雙側小腦半毬、雙側島葉、前釦帶迴、雙側中央前迴、輔助運動區及左側海馬、舌迴,激活增高的區域為右側楔前葉;右側顳葉癲癇組與對照組比較,腦功能激活減低的區域有右側額下迴、中央後迴及島葉.說明左側顳葉癲癇對語言相關功能區的影響較大.結論 顳葉癲癇患者動詞生成任務Bold-fMRI腦功能激活範圍及彊度較健康對照組明顯降低,以左側顳葉癲癇者為著.
목적 이용Bold-fMRI연구섭협전간(TLE)환자여정상대조조재어언임무모식하뇌격활적차이,탐토섭협전간환자뇌어언공능개변적영상학표현.방법 대경과수술병리증실적17례발작간기우리수TLE환자급상필배14례정상대조자행동사생성어언임무적뇌부Bold-fMRI검사.채용SPM 8연건대Bold-fMRI뇌공능도상진행수거처리화분석,채용량양본t검험비교전간조화대조조동사생성어언임무적fMRI격활도차이.결과 Bold-fMRI뇌격활결과현시,좌측섭협전간조여대조조비교뇌공능격활감저적구역유쌍측액하회、섭하회、쌍측침협、쌍측소뇌반구、쌍측도협、전구대회、쌍측중앙전회、보조운동구급좌측해마、설회,격활증고적구역위우측설전협;우측섭협전간조여대조조비교,뇌공능격활감저적구역유우측액하회、중앙후회급도협.설명좌측섭협전간대어언상관공능구적영향교대.결론 섭협전간환자동사생성임무Bold-fMRI뇌공능격활범위급강도교건강대조조명현강저,이좌측섭협전간자위저.
Objective To study the difference in the brain activation under the language task between patients with temporal lobe epilepsy(TLE)and the normal people using Blood oxygen level dependent-functional magnetic resonance imaging(BOLD-fMRI), and to investigate the language impairment of the temporal lobe epilepsy patients.Methods Seventeen right-handed patients with pathologic confirmed TLE and Fourteen right-handed healthy volunteers were recruited for the study. BOLD-fMRI were performed with verbal tasks. The BOLD-fMRI brain images were analyzed using SPM8, and two-samplet test was performed to compare the difference of language features and the brain activation between the epilepsy group and the control group. Results In verbal generation task, compared with the control group, negative activated differences were found in the group with left TLE in the following brain regions: bilateral inferior frontal gyrus, inferior temporal gyrus, bilateral occipital lobe, bilateral cerebellar hemispheres, bilateral anterior cingulate gyrus, insula, supplementary motor area and the left hippocampus, lingual gyrus. While in the group with right TLE, the negative activated differences were found in right inferior frontal gyrus, right postcentral gyrus and right insula. Conclusion The BOLD-fMRI brain activation range and intensity of the patients with left temporal lobe epilepsy were significantly lower than that of the healthy controls, especially in patients with left temporal lobe epilepsy.
