中国医疗器械杂志
中國醫療器械雜誌
중국의료기계잡지
Chinese Journal of Medical lnstrumentation
2015年
6期
423-426
,共4页
纳米抗体%诊断检测%分子成像%癌症
納米抗體%診斷檢測%分子成像%癌癥
납미항체%진단검측%분자성상%암증
nanobody%diagnosis and detection%molecular imaging%cancer
纳米抗体(nanobody, Nb)是存在于骆驼科血液中的一种天然缺失轻链的重链抗体。以纳米抗体为基础的分子探针和放射性核素,近红外染料,超声微泡等相结合,被应用到多种疾病的分子成像。该文结合最近几年纳米抗体在分子成像中的应用和临床数据,来介绍它作为一种新型的分子成像工具在疾病诊断中的应用及未来发展方向。
納米抗體(nanobody, Nb)是存在于駱駝科血液中的一種天然缺失輕鏈的重鏈抗體。以納米抗體為基礎的分子探針和放射性覈素,近紅外染料,超聲微泡等相結閤,被應用到多種疾病的分子成像。該文結閤最近幾年納米抗體在分子成像中的應用和臨床數據,來介紹它作為一種新型的分子成像工具在疾病診斷中的應用及未來髮展方嚮。
납미항체(nanobody, Nb)시존재우락타과혈액중적일충천연결실경련적중련항체。이납미항체위기출적분자탐침화방사성핵소,근홍외염료,초성미포등상결합,피응용도다충질병적분자성상。해문결합최근궤년납미항체재분자성상중적응용화림상수거,래개소타작위일충신형적분자성상공구재질병진단중적응용급미래발전방향。
Nanobodies are derived from the variable domain of the heavy-chain antibodies (HCAbs) that occur naturaly in the serum of camels. Using nanobody-based probes, several imaging techniques such as radionuclide-based, optical and ultrasound have been employed for visualization of target expression in various disease models. Combined with application and clinical data of nanobody in molecular imaging in recent years, this paper introduces its application in the diagnosis of diseases and the future development as a novel molecular imaging tool.