中华实用儿科临床杂志
中華實用兒科臨床雜誌
중화실용인과림상잡지
Journal of Applied Clinical Pediatrics
2015年
22期
1729-1731
,共3页
支气管哮喘%呼出气一氧化氮%肺功能%一秒钟用力呼气容积占预计值百分比
支氣管哮喘%呼齣氣一氧化氮%肺功能%一秒鐘用力呼氣容積佔預計值百分比
지기관효천%호출기일양화담%폐공능%일초종용력호기용적점예계치백분비
Bronchial asthma%Exhaled nitric oxide%Lung function%Percentage of expected value of forced expiratory volume in one second
目的 探讨呼出气一氧化氮(FeNO)在支气管哮喘(哮喘)患儿各期中的变化及其与肺功能的相关性和临床意义.方法 选择在南京医科大学附属南京儿童医院哮喘门诊就诊的6～14岁的哮喘患儿79例,其中急性发作期25例,慢性持续期28例,缓解期26例.简单随机抽样选取健康儿童25例作为健康对照组,分别测定其FeNO和肺功能,分析FeNO和肺功能在各组受试对象之间差异是否存在统计学意义,并比较其Fe-NO与肺功能指标是否存在相关性.结果 FeNO、1秒钟用力呼气容积占预计值百分比(FEV1％)在哮喘急性发作期[(58.79±12.25) ppb和(52.25±7.89)％]、慢性持续期[(42.13±11.38) ppb和(66.14±5.29)％]、缓解期[(25.41±7.15) ppb和(86.22±15.21)％]及健康对照组[(12.84±6.22) ppb和(93.62±12.13)％]之间比较,FeNO在哮喘急性发作期组、慢性持续期组、缓解期组水平均较健康对照组高,差异均有统计学意义(P均＜0.05).FEV1％除在缓解期与健康对照组比较差异无统计学意义(P＞0.05)外,余差异均有统计学意义(P均＜0.05).急性发作期FeNO与FEV1％呈负相关(r=-0.779,P=0.000),慢性持续期及缓解期的FeNO与FEV1％无相关性.结论 哮喘患儿FeNO水平增高,FeNO是反映呼吸道炎症的灵敏指标,可用来评价呼吸道炎症的控制情况和病情轻重程度.急性发作期哮喘患儿FeNO与肺功能中FEV1％呈负相关.
目的 探討呼齣氣一氧化氮(FeNO)在支氣管哮喘(哮喘)患兒各期中的變化及其與肺功能的相關性和臨床意義.方法 選擇在南京醫科大學附屬南京兒童醫院哮喘門診就診的6～14歲的哮喘患兒79例,其中急性髮作期25例,慢性持續期28例,緩解期26例.簡單隨機抽樣選取健康兒童25例作為健康對照組,分彆測定其FeNO和肺功能,分析FeNO和肺功能在各組受試對象之間差異是否存在統計學意義,併比較其Fe-NO與肺功能指標是否存在相關性.結果 FeNO、1秒鐘用力呼氣容積佔預計值百分比(FEV1％)在哮喘急性髮作期[(58.79±12.25) ppb和(52.25±7.89)％]、慢性持續期[(42.13±11.38) ppb和(66.14±5.29)％]、緩解期[(25.41±7.15) ppb和(86.22±15.21)％]及健康對照組[(12.84±6.22) ppb和(93.62±12.13)％]之間比較,FeNO在哮喘急性髮作期組、慢性持續期組、緩解期組水平均較健康對照組高,差異均有統計學意義(P均＜0.05).FEV1％除在緩解期與健康對照組比較差異無統計學意義(P＞0.05)外,餘差異均有統計學意義(P均＜0.05).急性髮作期FeNO與FEV1％呈負相關(r=-0.779,P=0.000),慢性持續期及緩解期的FeNO與FEV1％無相關性.結論 哮喘患兒FeNO水平增高,FeNO是反映呼吸道炎癥的靈敏指標,可用來評價呼吸道炎癥的控製情況和病情輕重程度.急性髮作期哮喘患兒FeNO與肺功能中FEV1％呈負相關.
목적 탐토호출기일양화담(FeNO)재지기관효천(효천)환인각기중적변화급기여폐공능적상관성화림상의의.방법 선택재남경의과대학부속남경인동의원효천문진취진적6～14세적효천환인79례,기중급성발작기25례,만성지속기28례,완해기26례.간단수궤추양선취건강인동25례작위건강대조조,분별측정기FeNO화폐공능,분석FeNO화폐공능재각조수시대상지간차이시부존재통계학의의,병비교기Fe-NO여폐공능지표시부존재상관성.결과 FeNO、1초종용력호기용적점예계치백분비(FEV1％)재효천급성발작기[(58.79±12.25) ppb화(52.25±7.89)％]、만성지속기[(42.13±11.38) ppb화(66.14±5.29)％]、완해기[(25.41±7.15) ppb화(86.22±15.21)％]급건강대조조[(12.84±6.22) ppb화(93.62±12.13)％]지간비교,FeNO재효천급성발작기조、만성지속기조、완해기조수평균교건강대조조고,차이균유통계학의의(P균＜0.05).FEV1％제재완해기여건강대조조비교차이무통계학의의(P＞0.05)외,여차이균유통계학의의(P균＜0.05).급성발작기FeNO여FEV1％정부상관(r=-0.779,P=0.000),만성지속기급완해기적FeNO여FEV1％무상관성.결론 효천환인FeNO수평증고,FeNO시반영호흡도염증적령민지표,가용래평개호흡도염증적공제정황화병정경중정도.급성발작기효천환인FeNO여폐공능중FEV1％정부상관.
Objective To investigate the correlation with lung function and clinical significance of lung function and exhaled nitric oxide (FeNO) changes in various disease stages for children with asthma.Methods Seventy-nine asthma outpatient children aged 6-14 years old were selected from Nanjing Children's Hospital Affiliated to Nanjing Medical University,25 cases of whom were at acute exacerbation stage,28 cases at chronic persistent stage and 26 cases at remission stage.Twenty-five healthy children were randomly selected as the healthy control group, for whom FeNO and lung functions were measured respectively.FeNO and lung functions were analyzed on whether there were statistical differences between the subjects in these groups and whether their FeNO and lung functions were correlated.Results Comparison of FeNO and the percentages of the expected value(FEV1 ％) of forced expiratory volume in one second between acute exacerbation group [(58.79 ± 12.25) ppb and (52.25 ± 7.89) ％], chronic persistent group [(42.13 ± 11.38) ppb and (66.14 ± 5.29) ％], remission group [(25.41 ± 7.15) ppb and (86.22 ± 15.21) ％] and the healthy control group [(12.84 ± 6.22) ppb and (93.62 ± 12.13)％], showed that FeNO in asthma acute exacerbation group, chronic persistent group and remission group was higher than that in the healthy control group, with statistically significant difference(all P ＜0.05).Except for remission group,in which FEV1 was not statistically significant different from the healthy control group (P ＞ 0.05) ,the differences in other groups were all statistically significant(all P ＜ 0.05).FeNO and FEV1％ were negatively correlated at acute exacerbation (r =-0.779, P =0.000) , but they were not correlated at chronic persistent and remission state.Conclusions FeNO values increased in asthma children.FeNO as a sensitive indicator to reflect airway inflammation can be used to evaluate the control and severity of airway inflammation.FeNO and FEV1％ of lung functions were negatively correlated in asthma children at acute stage.
