CAJ | 학술논문

为探索北京市产妇母乳中典型全氟化合物的污染水平及婴儿经母乳的外暴露水平及风险.于2011~2012年通过征集母乳捐献志愿者方式采集95份母乳样本,并填写调查表,记录母乳捐献者的人口学特征及居住环境等信息.采用固相萃取结合超高效液相色谱-串联质谱法测定母乳中全氟辛酸及全氟辛烷磺酸的含量,估算婴儿经母乳的每日摄入量并与参考剂量进行比较.结果显示北京市产妇母乳中全氟辛酸含量均值和中位数分别为42和37.4pg/mL,范围在13.4~181.3pg/mL之间.全氟辛烷磺酸含量高于全氟辛酸,均值、中位数和范围分别为66.6、54.5和14~390.3pg/mL,统计分析发现全氟辛酸与体重指数呈正相关但与母乳产出时间呈负相关,而全氟辛烷磺酸则与产妇年龄呈正相关.婴儿经母乳全氟辛酸和全氟辛烷磺酸每日摄入量中值分别为4.67和6.81ng/(kg bw·d),最高值分别为22.66和48.79ng/(kg bw?d),显示部分婴儿经母乳摄入的全氟辛烷磺酸水平超过了参考剂量,健康风险值得关注.
위탐색북경시산부모유중전형전불화합물적오염수평급영인경모유적외폭로수평급풍험.우2011~2012년통과정집모유연헌지원자방식채집95빈모유양본,병전사조사표,기록모유연헌자적인구학특정급거주배경등신식.채용고상췌취결합초고효액상색보-천련질보법측정모유중전불신산급전불신완광산적함량,고산영인경모유적매일섭입량병여삼고제량진행비교.결과현시북경시산부모유중전불신산함량균치화중위수분별위42화37.4pg/mL,범위재13.4~181.3pg/mL지간.전불신완광산함량고우전불신산,균치、중위수화범위분별위66.6、54.5화14~390.3pg/mL,통계분석발현전불신산여체중지수정정상관단여모유산출시간정부상관,이전불신완광산칙여산부년령정정상관.영인경모유전불신산화전불신완광산매일섭입량중치분별위4.67화6.81ng/(kg bw·d),최고치분별위22.66화48.79ng/(kg bw?d),현시부분영인경모유섭입적전불신완광산수평초과료삼고제량,건강풍험치득관주.
Two perfluorinated compounds (PFCs), perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), were measured in 95 human milk samples collected from Beijing in 2011~2012. The donors' personal information, such as dietary habit and socioeconomic and lifestyle factors, were obtained by questionnaires. Ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) analysis indicated that the levels of PFOA ranged from 13.4 to 181.3pg/mL, with the mean and median values of 42 and 37.4pg/mL, respectively. Levels of PFOS were normally higher than PFOA. The levels of PFOS ranged from 14 to 390.3pg/mL, with the mean and median values of 66.6 and 54.5pg/mL, respectively. Body mass index (BMI) was positive related to the levels of PFOA, whereas the time of nursing was negative related to PFOA. For PFOS, only the mother's age was found positive relative to the levels of PFOS. Median daily intakes (DIs) of PFOA and PFOS by breast-fed infants were 4.67 and 6.81ng/(kg bw?d), with the highest DIs of 22.66 and 48.79ng/(kg bw?d), respectively. The results indicated that the ingestion rates of PFOS for some infants exceed the reference dose (RfD), which could lead to possible toxicological impact. Thus, more research is needed to assess possible risk associated to PFCs contamination during early stages of life.