CAJ | 학술논문

发笑癫(痫)是一种伴发作性哭笑的特殊的难治性癫(痫),按其癫(痫)源带的不同可以分为皮质源性发笑癫(痫)和下丘脑错构瘤源性发笑癫(痫).目前,国内学者对发笑癫(痫)涉及的发病机制与临床治疗缺乏系统的认识.近年来,国外学者对发笑癫(痫)的研究取到不少进展,这些进展包括发笑癫(痫)中的发笑机制,下丘脑错构瘤源性发笑癫(痫)的原发性致(痫)分子机制,下丘脑错构瘤源性发笑癫(痫)中的继发性致(痫)源机制以及发笑癫(痫)的临床治疗.现对发笑癫(痫)发病机制与临床治疗研究进展做一综述.
발소전(간)시일충반발작성곡소적특수적난치성전(간),안기전(간)원대적불동가이분위피질원성발소전(간)화하구뇌착구류원성발소전(간).목전,국내학자대발소전(간)섭급적발병궤제여림상치료결핍계통적인식.근년래,국외학자대발소전(간)적연구취도불소진전,저사진전포괄발소전(간)중적발소궤제,하구뇌착구류원성발소전(간)적원발성치(간)분자궤제,하구뇌착구류원성발소전(간)중적계발성치(간)원궤제이급발소전(간)적림상치료.현대발소전(간)발병궤제여림상치료연구진전주일종술.
Gelastic epilepsy is a special refractory epilepsy accompany with ictal laughing and/or crying which can be divided into cortical induced gelastic epilepsy and hypothalamic hamartomas induced gelastic epilepsy according to their epileptogenic focus.Currently, domestic scholars had lack of systematic understanding of the mechanism and clinical treatment involved in gelastic epilepsy.Recently, foreign scholars had achieved great progress in the research of gelastic epilepsy which included the ictal laughing mechanism in gelastic epilepsy, the primary molecular mechanism in hypothalamic hamartomas induced gelastic epilepsy, the secondary epileptogenesis mechanism in hypothalamic hamartomas induced gelastic epilepsy and the clinical treatment of gelastic epilepsy.Now, the study progress of pathogenesis and clinical treatment of gelastic epilepsy were reviewed.