CAJ | 학술논문

应激性心肌病又称为Tako-Tsubo综合征，绝经期后的女性常见，主要特点是可逆性室壁运动异常，临床表现与急性心肌梗死相似，冠状动脉造影一般正常，典型的左室造影表现为“章鱼篓”样。应激性心肌病发病之前多存在精神或躯体应激因素，主要发病机制可能为儿茶酚胺介导的心肌损伤。miRNA作为一类具有调控功能的小分子非编码RNA，能通过与靶mRNA特异性结合来调节基因表达。体液中稳定表达的miRNA与很多心血管疾病有密切关系，在心血管疾病的早期诊断中发挥了越来越重要的作用。
응격성심기병우칭위Tako-Tsubo종합정，절경기후적녀성상견，주요특점시가역성실벽운동이상，림상표현여급성심기경사상사，관상동맥조영일반정상，전형적좌실조영표현위“장어루”양。응격성심기병발병지전다존재정신혹구체응격인소，주요발병궤제가능위인다분알개도적심기손상。miRNA작위일류구유조공공능적소분자비편마RNA，능통과여파mRNA특이성결합래조절기인표체。체액중은정표체적miRNA여흔다심혈관질병유밀절관계，재심혈관질병적조기진단중발휘료월래월중요적작용。
Stress cardiomyopathy, also known as Tako-Tsubo syndrome, is a primary cardiomyopathy charac-terized with reversible ventricular wall motion abnormality. Its clinical manifestations are similar to acute myocardial infarction. Most patients had normal manifestations in coronary angiography (CAG), but typical "chapter creel"-like characteristics in left ventricular angiography. Stress cardiomyopathy is commonly seen in postmenopausal women and often caused by mental or physical stress factors. The pathogenesis remains unknown, but the consensus is the cat-echolamine-mediated myocardial injury. In cells, miRNA-specific binding to the target mRNA could regulate gene ex-pression. At the same time, the stable expression of miRNA in body fluids is closely related to many cardiovascular diseases. In recent years, researches found that the peripheral blood miRNAs could be used as potential biomarkers for the early diagnosis of cardiovascular disease.