海南医学
海南醫學
해남의학
Hainan Medical Journal
2015年
22期
3304-3306,3307
,共4页
李其华%韦金儒%唐泉%银建斌%蒋芳勇
李其華%韋金儒%唐泉%銀建斌%蔣芳勇
리기화%위금유%당천%은건빈%장방용
肾小球滤过率%冠心病%冠状动脉狭窄
腎小毬濾過率%冠心病%冠狀動脈狹窄
신소구려과솔%관심병%관상동맥협착
Glomerular filtration rate%Coronary artery disease%Coronary artery stenosis
目的：研究估测的肾小球滤过率(eGFR)与冠心病及冠状动脉狭窄程度的关系。方法纳入因高度疑诊冠心病行选择性冠状动脉造影的住院患者349例，根据eGFR水平分为三组，其中高eGFR组(eGFR≥90 ml/min·1.73 m)125例，中eGFR组(60 ml/min·1.73 m≤eGFR<90 ml/min·1.73 m)118例，低eGFR组(eGFR<60 ml/min·1.73 m)106例。冠心病的诊断标准为主要冠状动脉或其主要分支直径狭窄≥50%，冠状动脉狭窄程度的评估采用Gensini评分系统。比较各组患者临床特点、冠心病所占比例以及冠状动脉狭窄积分有无差异。采用双变量相关与多因素Logistic回归分析eGFR与冠心病及冠状动脉狭窄程度的相关性。结果与高eGFR组比较，中、低eGFR组冠心病比例增大，冠状动脉狭窄积分增加(P<0.05)。双变量相关分析显示eGFR与冠心病和冠状动脉狭窄积分呈负相关关系(r值分别为-0.380、-0.315，P均<0.05)。多因素Logistic回归分析显示eGFR降低与冠心病与冠状动脉狭窄程度有关，是影响冠心病发生以及冠状动脉狭窄程度加重的独立危险因素(OR值分别为1.450和1.374，95%CI分别为1.026~2.241和1.047~2.164，P<0.05)。结论 eGFR与冠心病及冠状动脉狭窄程度显著相关，是影响冠心病发生及冠状动脉狭窄程度加重的独立危险因素。
目的：研究估測的腎小毬濾過率(eGFR)與冠心病及冠狀動脈狹窄程度的關繫。方法納入因高度疑診冠心病行選擇性冠狀動脈造影的住院患者349例，根據eGFR水平分為三組，其中高eGFR組(eGFR≥90 ml/min·1.73 m)125例，中eGFR組(60 ml/min·1.73 m≤eGFR<90 ml/min·1.73 m)118例，低eGFR組(eGFR<60 ml/min·1.73 m)106例。冠心病的診斷標準為主要冠狀動脈或其主要分支直徑狹窄≥50%，冠狀動脈狹窄程度的評估採用Gensini評分繫統。比較各組患者臨床特點、冠心病所佔比例以及冠狀動脈狹窄積分有無差異。採用雙變量相關與多因素Logistic迴歸分析eGFR與冠心病及冠狀動脈狹窄程度的相關性。結果與高eGFR組比較，中、低eGFR組冠心病比例增大，冠狀動脈狹窄積分增加(P<0.05)。雙變量相關分析顯示eGFR與冠心病和冠狀動脈狹窄積分呈負相關關繫(r值分彆為-0.380、-0.315，P均<0.05)。多因素Logistic迴歸分析顯示eGFR降低與冠心病與冠狀動脈狹窄程度有關，是影響冠心病髮生以及冠狀動脈狹窄程度加重的獨立危險因素(OR值分彆為1.450和1.374，95%CI分彆為1.026~2.241和1.047~2.164，P<0.05)。結論 eGFR與冠心病及冠狀動脈狹窄程度顯著相關，是影響冠心病髮生及冠狀動脈狹窄程度加重的獨立危險因素。
목적：연구고측적신소구려과솔(eGFR)여관심병급관상동맥협착정도적관계。방법납입인고도의진관심병행선택성관상동맥조영적주원환자349례，근거eGFR수평분위삼조，기중고eGFR조(eGFR≥90 ml/min·1.73 m)125례，중eGFR조(60 ml/min·1.73 m≤eGFR<90 ml/min·1.73 m)118례，저eGFR조(eGFR<60 ml/min·1.73 m)106례。관심병적진단표준위주요관상동맥혹기주요분지직경협착≥50%，관상동맥협착정도적평고채용Gensini평분계통。비교각조환자림상특점、관심병소점비례이급관상동맥협착적분유무차이。채용쌍변량상관여다인소Logistic회귀분석eGFR여관심병급관상동맥협착정도적상관성。결과여고eGFR조비교，중、저eGFR조관심병비례증대，관상동맥협착적분증가(P<0.05)。쌍변량상관분석현시eGFR여관심병화관상동맥협착적분정부상관관계(r치분별위-0.380、-0.315，P균<0.05)。다인소Logistic회귀분석현시eGFR강저여관심병여관상동맥협착정도유관，시영향관심병발생이급관상동맥협착정도가중적독립위험인소(OR치분별위1.450화1.374，95%CI분별위1.026~2.241화1.047~2.164，P<0.05)。결론 eGFR여관심병급관상동맥협착정도현저상관，시영향관심병발생급관상동맥협착정도가중적독립위험인소。
Objective To explore the correlation between glomerular filtration rate (eGFR) and coronary ar-tery disease (CAD), as well as between eGFR and coronary artery stenosis. Methods A total of 349 hospitalized patients undergoing coronary angiography were enrolled into this research, which were divided into three groups according to eG-FR level:high eGFR group (eGFR≥90 ml/min·1.73 m, 125 cases), moderate eGFR group (60 ml/min·1.73 m≤eGFR<90 ml/min·1.73 m, 118 cases), and low eGFR group (eGFR<60 ml/min·1.73 m, 106 cases). CAD was defined as over 50%reduction of lumen diameter at least in one major coronary artery. The severity of coronary artery stenosis was de-fined by the Gensini score. The baseline clinical characteristics and coronary angiogram were compared among vari-ous groups. Bivariate correlation and multivariate logistic regression analysis were performed to analyze the correla-tion between eGFR and CAD, as well as between eGFR and coronary artery stenosis. Results Incidence of CAD, and Gensini score of coronary artery in moderate and low eGFR group were significantly higher than that in high eG-FR group (P<0.05). Bivariate correlation analysis showed that eGFR was negatively correlated with CAD and Gensini score of coronary artery stenosis (r=-0.380 and r=-0.315, respectively, all P<0.05). Multivariate logistic regression analysis showed that eGFR was independent risk factor for CAD and coronary artery stenosis (OR=1.450, 95%CI:1.026~2.241 and OR=1.374, 95%CI:1.047~2.164, respectively, all P<0.05). Conclusion eGFR is closely correlated with CAD and coronary artery stenosis. It serves as an independent risk factor for CAD and coronary artery stenosis.
