国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
International Journal of Respiration
2015年
20期
1541-1544
,共4页
陈澄%张秀琴%沈续瑞%周娜娜%黄建安
陳澄%張秀琴%瀋續瑞%週娜娜%黃建安
진징%장수금%침속서%주나나%황건안
呼出气一氧化氮%支气管哮喘%咳嗽变异性哮喘
呼齣氣一氧化氮%支氣管哮喘%咳嗽變異性哮喘
호출기일양화담%지기관효천%해수변이성효천
Fractional exhaled nitric oxide%Bronchial asthma%Cough variant asthma
目的 评估呼出气一氧化氮(FeNO)在典型哮喘及咳嗽变异性哮喘(CVA)诊断和鉴别中的临床应用价值.方法 对苏州大学附属第一医院呼吸内科门诊2013年2月至2014年2月疑诊哮喘患者分别进行肺功能及激发试验检测,根据患者症状及激发试验结果将患者分为典型哮喘组、CVA组、非哮喘组,测量3组患者FeNO值.结果 本研究共入组典型哮喘组130例,CVA组80例,非哮喘组92例,典型哮喘组的FeNO值为(78±55) ppb,高于CVA组[(41±18) ppb,P＜0.001],两者均显著高于非哮喘组[(23±17) ppb,P＜0.001].两者之间最佳界值为48,曲线下面积为0.746(95％CI0.679～0.812),敏感度为70％,特异度为77.5％.诊断典型哮喘最佳界值为40,曲线下面积为0.888(95％ CI0.844～0.931),敏感度为78.5％,特异度为92.4％.诊断CVA最佳界值为33,曲线下面积为0.820(95％CI0.755～0.884),敏感度为82.5％,特异度为72.8％.结论 FeNO用于诊断和鉴别典型哮喘及CVA的敏感性和特异性都是可接受的,可以用于两者诊断鉴别的辅助工具.
目的 評估呼齣氣一氧化氮(FeNO)在典型哮喘及咳嗽變異性哮喘(CVA)診斷和鑒彆中的臨床應用價值.方法 對囌州大學附屬第一醫院呼吸內科門診2013年2月至2014年2月疑診哮喘患者分彆進行肺功能及激髮試驗檢測,根據患者癥狀及激髮試驗結果將患者分為典型哮喘組、CVA組、非哮喘組,測量3組患者FeNO值.結果 本研究共入組典型哮喘組130例,CVA組80例,非哮喘組92例,典型哮喘組的FeNO值為(78±55) ppb,高于CVA組[(41±18) ppb,P＜0.001],兩者均顯著高于非哮喘組[(23±17) ppb,P＜0.001].兩者之間最佳界值為48,麯線下麵積為0.746(95％CI0.679～0.812),敏感度為70％,特異度為77.5％.診斷典型哮喘最佳界值為40,麯線下麵積為0.888(95％ CI0.844～0.931),敏感度為78.5％,特異度為92.4％.診斷CVA最佳界值為33,麯線下麵積為0.820(95％CI0.755～0.884),敏感度為82.5％,特異度為72.8％.結論 FeNO用于診斷和鑒彆典型哮喘及CVA的敏感性和特異性都是可接受的,可以用于兩者診斷鑒彆的輔助工具.
목적 평고호출기일양화담(FeNO)재전형효천급해수변이성효천(CVA)진단화감별중적림상응용개치.방법 대소주대학부속제일의원호흡내과문진2013년2월지2014년2월의진효천환자분별진행폐공능급격발시험검측,근거환자증상급격발시험결과장환자분위전형효천조、CVA조、비효천조,측량3조환자FeNO치.결과 본연구공입조전형효천조130례,CVA조80례,비효천조92례,전형효천조적FeNO치위(78±55) ppb,고우CVA조[(41±18) ppb,P＜0.001],량자균현저고우비효천조[(23±17) ppb,P＜0.001].량자지간최가계치위48,곡선하면적위0.746(95％CI0.679～0.812),민감도위70％,특이도위77.5％.진단전형효천최가계치위40,곡선하면적위0.888(95％ CI0.844～0.931),민감도위78.5％,특이도위92.4％.진단CVA최가계치위33,곡선하면적위0.820(95％CI0.755～0.884),민감도위82.5％,특이도위72.8％.결론 FeNO용우진단화감별전형효천급CVA적민감성화특이성도시가접수적,가이용우량자진단감별적보조공구.
Objective To assess the clinical value of exhaled nitric oxide for the diagnosis and differentiation of typical bronchial asthma (asthma) and cough variant asthma (CVA).Methods Newly diagnosed patients were enrolled FeNO, pulmonary function tests, bronchial hyperresponsiveness were compared.We have compared the clinical utilities of FeNO to diagnose and differentiate typical asthma and CVA.Results There were 80 cough variant asthma, 130 typical asthma patients and 92 non asthmatic in our study.FeNO was significantly higher in typical asthma (78 ± 55) ppb than in CVA [(41 ± 18) ppb, P ＜ 0.001] and both were significantly higher than non asthmatic patients [(23± 17) ppb, P ＜0.001] ,and in differentiating between the two groups showed a sensitivity of 70％ and a specificity of 77.5％ at the cutoff value of 48 ppb.The optimal FeNO cutoff value was 40 ppb with a sensitivity of 78.5％, a specificity of 92.4％ for the diagnosis of typical asthma and 33 ppb with a sensitivity of 82.5％, a specificity of 72.8％ for the diagnosis of CVA.Conclusions FeNO can be used as an additional diagnostic tool for the screening of patients with a suspected diagnosis of asthma.
