CAJ | 학술논문

目的：观察脂联素(APN)、白细胞介素-6(IL-6)及超敏C反应蛋白(hs-CRP)在2型糖尿病(T2DM)合并冠心病(CHD)患者中的水平，并探讨其相关性。方法选择临床确诊的T2DM患者80例，分为T2DM不伴CHD组40例(B组)和T2DM合并CHD组(C组)40例，并与40例健康体检者(A组)对照，采用酶联免疫吸附(ELISA)法测定三组受试者的血清APN、IL-6及hs-CRP的水平，常规检测糖化血红蛋白(GHbA1c)，并应用Pearson相关性分析统计其相关性。结果 C组患者血清hs-CRP、IL-6水平均明显高于B组和A组，且差异均有统计学意义(P<0.05)，而血清APN水平则明显低于B组和A组，且差异有统计学意义(P<0.05)；相关分析显示，C组患者的hs-CRP与IL-6水平呈显著正相关(r=0.725，P<0.05)，GHbA1c与hs-CRP及IL-6水平呈显著正相关(r=0.873、0.912，P均<0.01)，而APN与hs-CRP及IL-6水平呈显著负相关(r=-0.816、-0.79，P均<0.01)。结论 APN作为抗动脉粥样硬化(AS)病变的保护因子而IL-6、hs-CRP作为致AS病变的炎症因子，它们共同参与了T2DM合并CHD患者冠脉粥样硬化的发生发展，早期干预这些炎症因子的水平可有效延缓T2DM患者CHD的发生发展。
목적：관찰지련소(APN)、백세포개소-6(IL-6)급초민C반응단백(hs-CRP)재2형당뇨병(T2DM)합병관심병(CHD)환자중적수평，병탐토기상관성。방법선택림상학진적T2DM환자80례，분위T2DM불반CHD조40례(B조)화T2DM합병CHD조(C조)40례，병여40례건강체검자(A조)대조，채용매련면역흡부(ELISA)법측정삼조수시자적혈청APN、IL-6급hs-CRP적수평，상규검측당화혈홍단백(GHbA1c)，병응용Pearson상관성분석통계기상관성。결과 C조환자혈청hs-CRP、IL-6수평균명현고우B조화A조，차차이균유통계학의의(P<0.05)，이혈청APN수평칙명현저우B조화A조，차차이유통계학의의(P<0.05)；상관분석현시，C조환자적hs-CRP여IL-6수평정현저정상관(r=0.725，P<0.05)，GHbA1c여hs-CRP급IL-6수평정현저정상관(r=0.873、0.912，P균<0.01)，이APN여hs-CRP급IL-6수평정현저부상관(r=-0.816、-0.79，P균<0.01)。결론 APN작위항동맥죽양경화(AS)병변적보호인자이IL-6、hs-CRP작위치AS병변적염증인자，타문공동삼여료T2DM합병CHD환자관맥죽양경화적발생발전，조기간예저사염증인자적수평가유효연완T2DM환자CHD적발생발전。
Objective To investigate the serum levels of adiponectin (APN), interleukin-6 (IL-6), high sen-sitivity C-reactive protein (hs-CRP) and their correlation in patients of type 2 diabetes mellitus (T2DM) with coronary heart disease (CHD). Methods Eighty T2DM patients were divided into two groups:40 patients with CHD (group C) and 40 patients without CHD (group B). Forty healthy subjects were enrolled as the control people (group A). The levels of APN, IL-6 and hs-CRP in these three groups were measured by ELISA assay, and the level of glycosylated hemoglobin A1c (GHbA1c) was routinely detected. Pearson correlation analysis was used to analyze the correlation be-tween the three indexes. Results IL-6 and hs-CRP levels in group C were significantly higher than those in group B and group A (P<0.05), while APN level in group C was significantly lower compared with group B and group A (P<0.05). According to correlation analysis, serum hs-CRP level was positively correlated with IL-6 (r=0.725, P<0.05), with serum GHbA1c positively correlated with hs-CRP and IL-6 (r=0.873, 0.912, P<0.01), while serum APN level was negatively correlated with hs-CRP and IL-6 in group C (r=-0.816,-0.79, P<0.01). Conclusion APN is an antiath-erogenic factor for atheromatosis, while IL-6 and hs-CRP are inflammatory factors resulting in atheromatosis. These three factors all participate in the pathogenesis and progression of atherosclerosis in T2DM patients with CHD. Early intervention for these inflammatory factors level can effectively delay the development of CHD in T2DM patients.