北华大学学报（自然科学版）
北華大學學報（自然科學版）
북화대학학보（자연과학판）
Journal of Beihua University (Natural Science)
2015年
6期
753-756
,共4页
C-反应蛋白%弥漫大B细胞淋巴瘤%严重度
C-反應蛋白%瀰漫大B細胞淋巴瘤%嚴重度
C-반응단백%미만대B세포림파류%엄중도
C-reactive protein%diffuse large B cell lymphoma%severity
目的：探讨弥漫性大B淋巴瘤( DLBCL)患者的血清中C-反应蛋白( CRP )的表达以及其与病程和预后之间的关系.方法选取健康体检者47例,并收集同时期经病理确诊的DLBCL患者51例,采用酶联免疫法检测所有受试人群的CRP浓度.结果 DLBCL患者的CRP 浓度为(23.85±7.22)mg/L,相对于健康人群的(6.64±3.17)mg/L明显升高.随着临床分期的进展,CRP水平逐渐上升,与对照组及不同分期之间比较差异均具有统计学意义(P<0.05).高表达CRP患者化疗有效率为44.83%,低表达CRP组为77.27%,组间比较差异具有统计学意义(P<0.05,χ2=31.728). GCB组患者的血清CRP水平明显低于NGCB组,且均显著高于对照组,组间比较差异均具有统计学意义(P<0.05).结论 DLBCL患者进行CRP检测能够反映其疾病变化,并且能够应用于评估不同类型、分期和严重度.
目的：探討瀰漫性大B淋巴瘤( DLBCL)患者的血清中C-反應蛋白( CRP )的錶達以及其與病程和預後之間的關繫.方法選取健康體檢者47例,併收集同時期經病理確診的DLBCL患者51例,採用酶聯免疫法檢測所有受試人群的CRP濃度.結果 DLBCL患者的CRP 濃度為(23.85±7.22)mg/L,相對于健康人群的(6.64±3.17)mg/L明顯升高.隨著臨床分期的進展,CRP水平逐漸上升,與對照組及不同分期之間比較差異均具有統計學意義(P<0.05).高錶達CRP患者化療有效率為44.83%,低錶達CRP組為77.27%,組間比較差異具有統計學意義(P<0.05,χ2=31.728). GCB組患者的血清CRP水平明顯低于NGCB組,且均顯著高于對照組,組間比較差異均具有統計學意義(P<0.05).結論 DLBCL患者進行CRP檢測能夠反映其疾病變化,併且能夠應用于評估不同類型、分期和嚴重度.
목적：탐토미만성대B림파류( DLBCL)환자적혈청중C-반응단백( CRP )적표체이급기여병정화예후지간적관계.방법선취건강체검자47례,병수집동시기경병리학진적DLBCL환자51례,채용매련면역법검측소유수시인군적CRP농도.결과 DLBCL환자적CRP 농도위(23.85±7.22)mg/L,상대우건강인군적(6.64±3.17)mg/L명현승고.수착림상분기적진전,CRP수평축점상승,여대조조급불동분기지간비교차이균구유통계학의의(P<0.05).고표체CRP환자화료유효솔위44.83%,저표체CRP조위77.27%,조간비교차이구유통계학의의(P<0.05,χ2=31.728). GCB조환자적혈청CRP수평명현저우NGCB조,차균현저고우대조조,조간비교차이균구유통계학의의(P<0.05).결론 DLBCL환자진행CRP검측능구반영기질병변화,병차능구응용우평고불동류형、분기화엄중도.
Objective To explore the expression of C-reactive protein in diffuse large B cell lymphoma and its relationship with the course and the prognosis. Method Selected a total of 47 healthy cases and 51 patients with DLBCL diagnosed by pathology were enrolled. Enzyme-linked immunosorbent assay were applied to detect the CRP concentrations of the cases. Results Compared with the healthy people (6. 64 ±3. 17) mg/L,the CRP concentrations of the patients ( 23 . 85 ± 7 . 22 ) mg/L with DLBCL were significantly higher with the progress of clinical stage,the CRP levels increased gradually,and the comparison between different stages and the control group were statistically significant ( P<0 . 05 ) . The effective rates of chemotherapy in high and low CRP expression patients were 44. 83% and 77. 27%, respectively, with statistical significance (χ2 = 31. 728, P<0. 05). Serum CRP level of GCB group was lower than that of NGCB group,but was significantly higher than that of control group. The differences among the three groups were statistically significant ( P<0. 05 ). Conclusion CRP level detection in DLBCL patients can reflect the change of their diseases,and can be applied to evaluate the prognosis of the patients with different types,stages and severity of DLBCL.
