CAJ | 학술논문

目的：探讨归脾汤对产后抑郁模型大鼠行为学的干预作用。方法选用50只雌性 SD 大鼠,随机分为空白组、假手术组、模型组、归脾汤组、氟西汀组,每组再设1周和4周两个观察时点,分别对大鼠进行行为学测试,包括糖水消耗实验、旷场实验、强迫游泳实验,记录体重、糖水消耗量、旷场水平得分、旷场垂直得分、不动时间、挣扎时间、游泳时间,对不同组别、不同时间节点分别进行比较分析。结果造模后,大鼠体重、糖水消耗量、旷场水平得分、旷场垂直得分、挣扎时间均显著下降(P<0.05,P<0.01),不动时间显著延长(P<0.01),游泳时间下降,但无统计学意义；归脾汤处理4周后,模型大鼠体重、糖水消耗量、旷场水平得分、旷场垂直得分、挣扎时间、游泳时间均显著回升(P<0.05,P<0.01),不动时间显著缩短(P<0.01)。结论归脾汤对产后抑郁模型大鼠的抑郁行为有明显调节作用。
목적：탐토귀비탕대산후억욱모형대서행위학적간예작용。방법선용50지자성 SD 대서,수궤분위공백조、가수술조、모형조、귀비탕조、불서정조,매조재설1주화4주량개관찰시점,분별대대서진행행위학측시,포괄당수소모실험、광장실험、강박유영실험,기록체중、당수소모량、광장수평득분、광장수직득분、불동시간、쟁찰시간、유영시간,대불동조별、불동시간절점분별진행비교분석。결과조모후,대서체중、당수소모량、광장수평득분、광장수직득분、쟁찰시간균현저하강(P<0.05,P<0.01),불동시간현저연장(P<0.01),유영시간하강,단무통계학의의；귀비탕처리4주후,모형대서체중、당수소모량、광장수평득분、광장수직득분、쟁찰시간、유영시간균현저회승(P<0.05,P<0.01),불동시간현저축단(P<0.01)。결론귀비탕대산후억욱모형대서적억욱행위유명현조절작용。
Objective To explore the effect of Guipi decoction(GPD)on behavioristic in model rats with postpartum depression (PPD).Methods Fifty female Sprague Dawley (SD)rats were selected and randomly divided into blank group,sham operated group,model group,GPD group and fluoxetine group.At the time points of the end of 1st and 4th week,the behavioristics of the rats were observed,including sucrose consumption test,open field test (OFT)and forced swimming test (FST).The weight,sucrose con-sumption,horizontal scores of OFT,vertical scores of OFT,immobility time of FST,struggling time of FST and swimming time of FST were recorded and compared.Results The weight,sucrose consumption,horizontal scores of OFT,vertical scores of OFT ,the struggling time of FST in model group were lower than that in normal group(P<0.05 or P<0.01)while the immobility time of FST was longer than that in normal group (P<0.01).After 4 weeks,the weight,sucrose consumption,horizontal scores of OFT,vertical scores of OFT,struggling time of FST and swimming time of FST in GPD group were higher than that in model group(P<0.05 or P<0.01)while the immobility time of FST were lower than that in model group(P<0.01).Conclusion GPD can regulate the depressive behavior in model rats with PPD.