CAJ | 학술논문

目的：观察麝香保心丸对冠心病慢性心力衰竭患者的心功能、血流动力学及相关指标影响。方法100例冠心病慢性心力衰竭患者随机分为观察组和对照组，各50例。对照组采用西医常规治疗，观察组在西医常规治疗的基础上加用麝香保心丸。治疗6周后比较两组患者心功能、血浆 N末端脑钠肽前体(NT proBNP)和血清心型脂肪酸结合蛋白(H FABP)水平。结果两组治疗后左室射血分数(LVEF)、左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)、心输出量(CO)、每搏量(SV)及6 min步行距离均较治疗前有改善，观察组改善的程度优于对照组(P<0.05)；治疗后观察组血浆 NT proBNP和血清 H FABP水平均低于对照组(P<0.05)，观察组临床疗效优于对照组(P<0.05)。结论麝香保心丸可明显改善冠心病慢性心力衰竭患者的心脏舒缩功能，降低血浆 NT proBNP和 H FABP水平。
목적：관찰사향보심환대관심병만성심력쇠갈환자적심공능、혈류동역학급상관지표영향。방법100례관심병만성심력쇠갈환자수궤분위관찰조화대조조，각50례。대조조채용서의상규치료，관찰조재서의상규치료적기출상가용사향보심환。치료6주후비교량조환자심공능、혈장 N말단뇌납태전체(NT proBNP)화혈청심형지방산결합단백(H FABP)수평。결과량조치료후좌실사혈분수(LVEF)、좌실서장말내경(LVEDD)、좌실수축말내경(LVESD)、심수출량(CO)、매박량(SV)급6 min보행거리균교치료전유개선，관찰조개선적정도우우대조조(P<0.05)；치료후관찰조혈장 NT proBNP화혈청 H FABP수평균저우대조조(P<0.05)，관찰조림상료효우우대조조(P<0.05)。결론사향보심환가명현개선관심병만성심력쇠갈환자적심장서축공능，강저혈장 NT proBNP화 H FABP수평。
Objective To investigate the efficacy of Shexiang Baoxin pil (SBP)in treating chronic heart failure(CHF)induced by coro-nary heart disease(CHD).Methods One hundred patients with CHF induced by CHD were randomly divided into two groups:The control group(n=50)treated with routine treatment,and the treatment group(n=50)treated with routine treatment plus SBP for 6 weeks.The cardiac function,plasma N terminal pro brain type natriuretic peptide (NT proBNP)and serum heart fatty acid binding protein (H FABP)levels were observed.Results After treatment,left ventricular(LV)ejection fraction (LVEF),LV end di-astolic diameter (LVEDD),LV end systolic diameter(LVESD),cardiac output (CO),SV and 6 min walking distance were improved in two groups,the degree of improvement in treatment group was better than that in control group(P<0.05).The levels of plasma NT proBNP and serum H FABP in treatment group was lower than that in control group(P<0.05).The clinical efficacy in treat-ment group was better than that in control group(P<0.05).Conclusion SBP can improve the cardiac function,reduce the levels of plasma NT proBNP and serum H FABP in patients with CHF induced by CHD.