CAJ | 학술논문

目的：研究联合采用六味五灵片和熊去氧胆酸治疗失代偿期乙肝肝硬化的临床效果。方法：将2011~2014年我院收治的78例失代偿期乙肝肝硬化患者作为研究对象，将其随机分为治疗组（n＝38）和对照组（n＝40）。为两组患者采用常规抗病毒及保肝疗法进行治疗，在此基础上为治疗组患者联合采用六味五灵片和熊去氧胆酸进行治疗，为对照组患者应用水飞蓟宾胶囊进行治疗，然后在用药12周后对比观察其临床表现、肝功能指标及Child-pugh评分的变化情况、治疗的总有效率及发生不良反应的情况。结果：与对照组患者相比，治疗组患者在进行治疗后其肝功能指标、凝血酶原时间、Child-pugh的评分均较优，差异显著（P＜0.05），有统计学意义。与对照组患者相比，治疗组患者治疗的总有效率较高，差异显著(P＜0.05)，有统计学意义。两组患者在进行治疗期间均未发生明显的不良反应。结论：联合采用六味五灵片和熊去氧胆酸治疗失代偿期乙肝肝硬化可取得较好的临床效果，显著改善患者的肝功能，此法值得在临床上推广应用。
목적：연구연합채용륙미오령편화웅거양담산치료실대상기을간간경화적림상효과。방법：장2011~2014년아원수치적78례실대상기을간간경화환자작위연구대상，장기수궤분위치료조（n＝38）화대조조（n＝40）。위량조환자채용상규항병독급보간요법진행치료，재차기출상위치료조환자연합채용륙미오령편화웅거양담산진행치료，위대조조환자응용수비계빈효낭진행치료，연후재용약12주후대비관찰기림상표현、간공능지표급Child-pugh평분적변화정황、치료적총유효솔급발생불량반응적정황。결과：여대조조환자상비，치료조환자재진행치료후기간공능지표、응혈매원시간、Child-pugh적평분균교우，차이현저（P＜0.05），유통계학의의。여대조조환자상비，치료조환자치료적총유효솔교고，차이현저(P＜0.05)，유통계학의의。량조환자재진행치료기간균미발생명현적불량반응。결론：연합채용륙미오령편화웅거양담산치료실대상기을간간경화가취득교호적림상효과，현저개선환자적간공능，차법치득재림상상추엄응용。
Objective: To investigate the clinical effect of Liuweiwuling tablets combined ursodeoxycholic acid On HBV-induced decompensated cirrhosis. Methods: 78 HBV-induced decompensated cirrhosis patien ts from 2011 to 2014 were randomly divided into treatment group (n=38) and control group (n=40). After the conventional liver protecting treatment, treatment group received Liuweiwuling tablets combined ursodeoxycholic acid, and control group received Silibinin Capsules for 12 weeks. To detect clinical symptom, liver f unction, the change of Child-P ugh grade, total effective rate, adverse reactions, etc. Treatm ent effect between these 2 groups was compared. Results: The levels of total effective rate, TBIL, TBA, ALT, AST, ALP, GGT, CHE, ALB, PT, Child-Pugh grade on treatment group was obviously higher than control group. Conclusion: Clinical effect of Liuweiwuling tablets combined ursodeoxycholic acid on HBV-induced decompensated cirrhosis was better.