CAJ | 학술논문

目的：探讨茵栀黄口服液联合静脉滴注丹参注射液治疗孕期母儿血型不合的临床效果。方法选择孕期抗体效价>1：64并正常分娩的孕妇135例，随机分为西药组、中药组、中药+丹参组，每组45例。西药组常规给予25%葡萄糖+维生素 C 缓慢静推，鼻导管吸氧治疗；中药组口服茵栀黄口服液；中药+丹参组口服茵栀黄口服液，同时静脉滴注丹参注射液。观察孕妇不同抗体效价的治疗效果及新生儿黄疸的发生情况。结果当抗体效价<1：256时，中药组及中药加丹参组有效率均高于西药组，而中药组与中药加丹参组有效率比较，差异无统计学意义（ P >0.05）。当抗体效价>1：256时，中药组及中药加丹参组有效率均高于西药组，且中药加丹参组有效率高于中药组，差异有统计学意义（P <0.05）。中药组及中药加丹参组新生儿黄疸发生率低于西药组，差异有统计学意义（P <0.05）。结论茵栀黄口服液联合丹参注射液治疗孕期母儿血型不合可显著提高治疗效果，并且可使新生儿黄疸的发生率进一步降低，值得临床推广。
목적：탐토인치황구복액연합정맥적주단삼주사액치료잉기모인혈형불합적림상효과。방법선택잉기항체효개>1：64병정상분면적잉부135례，수궤분위서약조、중약조、중약+단삼조，매조45례。서약조상규급여25%포도당+유생소 C 완만정추，비도관흡양치료；중약조구복인치황구복액；중약+단삼조구복인치황구복액，동시정맥적주단삼주사액。관찰잉부불동항체효개적치료효과급신생인황달적발생정황。결과당항체효개<1：256시，중약조급중약가단삼조유효솔균고우서약조，이중약조여중약가단삼조유효솔비교，차이무통계학의의（ P >0.05）。당항체효개>1：256시，중약조급중약가단삼조유효솔균고우서약조，차중약가단삼조유효솔고우중약조，차이유통계학의의（P <0.05）。중약조급중약가단삼조신생인황달발생솔저우서약조，차이유통계학의의（P <0.05）。결론인치황구복액연합단삼주사액치료잉기모인혈형불합가현저제고치료효과，병차가사신생인황달적발생솔진일보강저，치득림상추엄。
Objective To analyze the clinical effect of Yinzhihuang Oral Solution combined with Salval in the treatment of maternal - fetal ABO blood group incompatibility. Methods A total of 145 cases of the maternal - fetal ABO blood group incompatibility whose antibody titer ≥1: 64 were included. Were ran-domly divided the patients into three groups:the 45 cases of these were treated with intravenous infusion of glucose and vitamin C. The 45 cases of these were administered with Yinzhihuang Oral Solution. While the rest 45 were treated with Yinzhihuang Oral Solution combined with Salval. A treatment course was 4 weeks. The variation of antibody titer of the pregnancy and the incidence of neonatal jaundice were observed. Results When the antibody titer was < 1: 256,the effect of Yinzhihuang Oral Solution and Salval group were higher than that of the western medicine group. There was no difference between Yinzhihuang Oral Solution and Salviae group(P > 0. 05). Moreover,when the antibody titer was > 1: 256,the effect of Yinzhihuang Oral So-lution was higher than that of the Salval group(P < 0. 05). The neonatal jaundice incidence of Yinzhihuang Oral Solution and Salval group was significantly better than that of the non - treatment group(P < 0. 05). Conclusion Yinzhihuang Oral Solution and Salval Significantly can improve the therapeutic effect and be-come much lower in neonatal jaundice incidence.