中国卫生产业
中國衛生產業
중국위생산업
China Health Industry
2015年
20期
195-198
,共4页
高分子量脂联素多聚体%慢性肾衰%诊疗
高分子量脂聯素多聚體%慢性腎衰%診療
고분자량지련소다취체%만성신쇠%진료
High molecular weight adiponectin multimers%Chronic renal failure%Treatment
目的：探讨血清高分子量脂联素多聚体水平检测在慢性患者诊疗中的临床价值。方法将该院2013年7月—2014年7月收治的80例慢性衰竭患者随机分成A、B两组，各40例，其中A组为非血液透析的患者、B组为血液透析的患者，然后取38例无慢性肾衰的健康人作为C组。比较三组检测后的临床效果。结果检测后，A组和B组的总APN水平、血清HMW-APN水平等均高于C组；B组粥样斑块发生率、IMT厚度等指标均高于A组，且差异有统计学意义（P<0.05）；B组血清HMW-APN水平明显低于A组，且差异有统计学意义（P<0.05）；在检测过程中，血清HMW-APN水平与尿氮素、肌酐成正相关，与甘油三酯呈负相关。另外，总APN水平与肌酐呈正相关。结论血清高分子量脂联素多聚体水平检测在慢性肾衰患者的诊疗中发挥着重要作用，并且同时检测血清HMP-APN与总APN水平能有效成为检测慢性肾衰的关键指标，以及较好的反映抗动脉硬化等并发症的产生，值得推广。
目的：探討血清高分子量脂聯素多聚體水平檢測在慢性患者診療中的臨床價值。方法將該院2013年7月—2014年7月收治的80例慢性衰竭患者隨機分成A、B兩組，各40例，其中A組為非血液透析的患者、B組為血液透析的患者，然後取38例無慢性腎衰的健康人作為C組。比較三組檢測後的臨床效果。結果檢測後，A組和B組的總APN水平、血清HMW-APN水平等均高于C組；B組粥樣斑塊髮生率、IMT厚度等指標均高于A組，且差異有統計學意義（P<0.05）；B組血清HMW-APN水平明顯低于A組，且差異有統計學意義（P<0.05）；在檢測過程中，血清HMW-APN水平與尿氮素、肌酐成正相關，與甘油三酯呈負相關。另外，總APN水平與肌酐呈正相關。結論血清高分子量脂聯素多聚體水平檢測在慢性腎衰患者的診療中髮揮著重要作用，併且同時檢測血清HMP-APN與總APN水平能有效成為檢測慢性腎衰的關鍵指標，以及較好的反映抗動脈硬化等併髮癥的產生，值得推廣。
목적：탐토혈청고분자량지련소다취체수평검측재만성환자진료중적림상개치。방법장해원2013년7월—2014년7월수치적80례만성쇠갈환자수궤분성A、B량조，각40례，기중A조위비혈액투석적환자、B조위혈액투석적환자，연후취38례무만성신쇠적건강인작위C조。비교삼조검측후적림상효과。결과검측후，A조화B조적총APN수평、혈청HMW-APN수평등균고우C조；B조죽양반괴발생솔、IMT후도등지표균고우A조，차차이유통계학의의（P<0.05）；B조혈청HMW-APN수평명현저우A조，차차이유통계학의의（P<0.05）；재검측과정중，혈청HMW-APN수평여뇨담소、기항성정상관，여감유삼지정부상관。령외，총APN수평여기항정정상관。결론혈청고분자량지련소다취체수평검측재만성신쇠환자적진료중발휘착중요작용，병차동시검측혈청HMP-APN여총APN수평능유효성위검측만성신쇠적관건지표，이급교호적반영항동맥경화등병발증적산생，치득추엄。
Objective To investigate the serum high molecular weight adiponectin multimers Levels clinical value in the di-agnosis and treatment of patients with chronic. Methods 80 patients with chronic failure patients admitted to our hospital from July 2013 to July 2014 were randomly divided into A, B groups, with 40 cases, of which A group of non-hemodialysis patients, hemodialysis patients in group B, and then take the 38 cases without chronic renal failure healthy people as a group C. Comparison of the three groups after the detection of clinical effect. Results After testing, the overall level of APN group A and group B, serum HMW-APN levels are higher than group C;group B plaque incidence, IMT thickness and oth-er indicators were higher than the A group, and the difference was stat istically show significance(P<0.05);serum HMW-APN group B was significantly lower than that in group A, and show a statistically significant difference(P<0.05);in the detection process, serum HMW-APN levels and urinary nitrogen, creatinine positively correlated negatively correlated with triglyc-erides. In addition, the total APN creatinine levels were positively correlated. Conclusions The serum high molecular weight adiponectin multimers level detection plays an important role in the diagnosis and treatment of patients with chronic renal failure, and simultaneous detection of serum total HMP-APN APN level detection can effectively become a key indicator of chronic renal failure , as well as better produced response against atherosclerosis and other complications , it is worth promoting.
