湖南师范大学学报（医学版）
湖南師範大學學報（醫學版）
호남사범대학학보（의학판）
Journal of Hunan Normal University (Medical Science)
2015年
5期
101-103
,共3页
李胜红%蔡宝珍%胡汉楚%霍小平
李勝紅%蔡寶珍%鬍漢楚%霍小平
리성홍%채보진%호한초%곽소평
酮替芬%黄芪颗粒%小儿咳嗽变异性哮喘
酮替芬%黃芪顆粒%小兒咳嗽變異性哮喘
동체분%황기과립%소인해수변이성효천
ketotifen%astragalus particles%children with cough variant asthma
目的：探讨酮替芬联合黄芪颗粒治疗小儿咳嗽变异性哮喘的临床疗效。方法：选择2012年5月～2014年6月我院儿科收治的咳嗽变异性哮喘患儿120例，将其随机分为观察组和对照组，每组60例，对照组给予酮替芬治疗，观察组在对照组基础上加用黄芪颗粒，两组均治疗两个月，比较两组临床疗效、治疗前后免疫功能变化以及不良反应。结果：观察组治疗总有效率为93.33%，对照组治疗总有效率为80.00%，两组比较，差异具有统计学意义；观察组治疗后IgA较治疗前显著升高，IgE较治疗前显著降低；而对照组治疗前后各体液免疫指标变化均无差异；观察组治疗后CD4+、CD4+/CD8+较治疗前显著升高，而治疗前后CD8+水平无变化；对照组各细胞免疫指标治疗前后均无变化；观察组不良反应发生率3.33%，对照组不良反应发生率13.33%，两组不良反应发生率比较，差异具有统计学意义。结论：酮替芬联合黄芪颗粒治疗小儿咳嗽变异性哮喘的临床疗效显著，且能够显著改善患儿的机体免疫功能，减少不良反应的发生率，值得临床推广运用。
目的：探討酮替芬聯閤黃芪顆粒治療小兒咳嗽變異性哮喘的臨床療效。方法：選擇2012年5月～2014年6月我院兒科收治的咳嗽變異性哮喘患兒120例，將其隨機分為觀察組和對照組，每組60例，對照組給予酮替芬治療，觀察組在對照組基礎上加用黃芪顆粒，兩組均治療兩箇月，比較兩組臨床療效、治療前後免疫功能變化以及不良反應。結果：觀察組治療總有效率為93.33%，對照組治療總有效率為80.00%，兩組比較，差異具有統計學意義；觀察組治療後IgA較治療前顯著升高，IgE較治療前顯著降低；而對照組治療前後各體液免疫指標變化均無差異；觀察組治療後CD4+、CD4+/CD8+較治療前顯著升高，而治療前後CD8+水平無變化；對照組各細胞免疫指標治療前後均無變化；觀察組不良反應髮生率3.33%，對照組不良反應髮生率13.33%，兩組不良反應髮生率比較，差異具有統計學意義。結論：酮替芬聯閤黃芪顆粒治療小兒咳嗽變異性哮喘的臨床療效顯著，且能夠顯著改善患兒的機體免疫功能，減少不良反應的髮生率，值得臨床推廣運用。
목적：탐토동체분연합황기과립치료소인해수변이성효천적림상료효。방법：선택2012년5월～2014년6월아원인과수치적해수변이성효천환인120례，장기수궤분위관찰조화대조조，매조60례，대조조급여동체분치료，관찰조재대조조기출상가용황기과립，량조균치료량개월，비교량조림상료효、치료전후면역공능변화이급불량반응。결과：관찰조치료총유효솔위93.33%，대조조치료총유효솔위80.00%，량조비교，차이구유통계학의의；관찰조치료후IgA교치료전현저승고，IgE교치료전현저강저；이대조조치료전후각체액면역지표변화균무차이；관찰조치료후CD4+、CD4+/CD8+교치료전현저승고，이치료전후CD8+수평무변화；대조조각세포면역지표치료전후균무변화；관찰조불량반응발생솔3.33%，대조조불량반응발생솔13.33%，량조불량반응발생솔비교，차이구유통계학의의。결론：동체분연합황기과립치료소인해수변이성효천적림상료효현저，차능구현저개선환인적궤체면역공능，감소불량반응적발생솔，치득림상추엄운용。
ObjectiveTo investigate the clinical efficacy of ketotifen combined with Astragalus granule in the treatment of children with cough variant asthma.Methods select 2012 May~2014 year in June my courtyard department of pediatrics were treated with cough variant asthma in 120 cases, randomly divided them into observation group and control group, 60 cases in each group, the control group was given ketotifen treatment, the observation group in the control group based on the use of Astragalus granule, two groups were treated for two months, the changes of immune function before and after treatment of clini-cal efficacy of two groups were compared, and the adverse reaction.Resultsin the observation group the total effective rate was 93.33%, the control group total effective rate was 80%, two groups, with statistically significant difference; the patients in the observation group IgA significantly increased, IgE decreased significantly; and the humoral immune indicators of changes in treatment group there was no difference before and after the treatment; the observation group after treatment, CD4+, CD4+/CD8+ were significantly increased, and CD8+ level had no change before and after treatment; the control group before and after the treatment showed no changes of cel immune index; adverse reaction in observation group was 3.33%, in control group, the ad-verse reaction rate of 13.33%, the occurrence of the two group of adverse reaction rate compared with statistically significant difference.
