CAJ | 학술논문

目的：研究血清中低密度脂蛋白（LDL）和氧化型低密度脂蛋白（ox‐LDL ）在临床诊断的价值，同时分析其与上皮性卵巢癌患者预后的相关性。方法选取2010年4月至2014年5月入院治疗的40例良性上皮性卵巢肿瘤患者、28例上皮性卵巢癌患者，以及同期来体检的30例健康体检者，比较各组标本血清中高密度脂蛋白、三酰甘油、LDL 和总胆固醇水平，分析血脂水平变化与上皮性卵巢癌分化的关系，同时对 LDL 及 ox‐LDL 水平与患者远期生存预测相关性进行分析。结果上皮性卵巢癌患者血清中 ox‐LDL 、LDL 水平显著高于健康体检者，差异有统计学意义（P＜0．05）；高分化型上皮性卵巢癌患者 ox‐LDL 和 LDL 水平显著高于其低、中分化型患者，差异有统计学意义（P＜0．05）；LDL 及 ox‐LDL 水平与患者远期生存预测有相关性。结论 LDL 及 ox‐LDL 水平改变是上皮性卵巢癌患者远期临床预后的重要预测因素，具有重要临床意义。
목적：연구혈청중저밀도지단백（LDL）화양화형저밀도지단백（ox‐LDL ）재림상진단적개치，동시분석기여상피성란소암환자예후적상관성。방법선취2010년4월지2014년5월입원치료적40례량성상피성란소종류환자、28례상피성란소암환자，이급동기래체검적30례건강체검자，비교각조표본혈청중고밀도지단백、삼선감유、LDL 화총담고순수평，분석혈지수평변화여상피성란소암분화적관계，동시대 LDL 급 ox‐LDL 수평여환자원기생존예측상관성진행분석。결과상피성란소암환자혈청중 ox‐LDL 、LDL 수평현저고우건강체검자，차이유통계학의의（P＜0．05）；고분화형상피성란소암환자 ox‐LDL 화 LDL 수평현저고우기저、중분화형환자，차이유통계학의의（P＜0．05）；LDL 급 ox‐LDL 수평여환자원기생존예측유상관성。결론 LDL 급 ox‐LDL 수평개변시상피성란소암환자원기림상예후적중요예측인소，구유중요림상의의。
Objective To study the diagnostic values of serum low density lipoprotein (LDL) and oxidation of serum lipoprotein (ox‐LDL ) in patients with epithelial ovarian cancer and their relationship with prognosis . Methods 40 cases of patients with ovarian tumor ,28 cases of patients with epithelial ovarian cancer ,and 30 cases of healthy people were enrolled in the study from April 2010 to May 2014 .The serum levels of high density lipoprotein in serum (HDL) ,three glycerol (TG) ,LDL and ox‐LDL of each group were detected and compared .The relationship between the changes of lipid levels and the differentiation of epithelial ovarian cancer was analyzed ,and the correlation between the levels of LDL and ox‐LDL and the long‐term survival prediction was also analyzed .Results The serum levels of ox‐LDL and LDL in patients with epithelial ovarian cancer were significantly higher than healthy people (P< 0 .05) .The serum levels of ox‐LDL and LDL in patients with well differentiated epithelial ovarian cancer were significantly higher than patients with moderately and poorly differentiated epithelial ovarian cancer (P< 0 .05) .The serum levels of LDL and ox‐LDL were related to the long‐term survival prediction .Conclusion The change of LDL and ox‐LDL levels is an important prediction factor of long‐term prognosis of patients with epithelial ovarian cancer , which has important clinical significance .