CAJ | 학술논문

目的：探讨高尿酸血症对2型糖尿病血管并发症的影响及作用机制。方法选取2013年6月至2014年6月于海南省农垦总医院进行治疗的2型糖尿病患者182例，根据患者尿酸水平的不同分为高尿酸血症组、低尿酸血症组和尿酸水平正常组。观察并比较各组患者生化指标及并发症发生情况。结果高尿酸血症组和低尿酸血症组患者总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL‐C）、体质量指数（BMI）均显著高于尿酸水平正常组患者，差异均有统计学意义（P ＜0．05），高尿酸血症组患者 TC 、TG 、LDL‐C 、BMI 均显著高于低尿酸血症组患者，差异均有统计学意义（P＜0．05）；高尿酸血症组和低尿酸血症组患者高密度脂蛋白胆固醇（HDL‐C）显著低于尿酸水平正常组患者，差异有统计学意义（P＜0．05），高尿酸血症组患者 HDL‐C 显著低于低尿酸血症组患者，差异有统计学意义（P＜0．05）。3组患者血压和空腹血糖比较差异均无统计学意义（P＞0．05）。高尿酸血症组患者微血管病变、大血管病变、神经病变、脑血管病、冠心病等血管并发症发生率均显著高于低尿酸血症组患者和尿酸水平正常组患者，差异有统计学意义（P＜0．05），低尿酸血症组和尿酸水平正常组患者血管并发症发生情况差异无统计学意义（P＞0．05）。结论高尿酸血症与患者的肥胖及血脂代谢异常具有显著相关性。高尿酸血症能够增加2型糖尿病患者代谢紊乱的机会，并促进其并发症的发生和发展。
목적：탐토고뇨산혈증대2형당뇨병혈관병발증적영향급작용궤제。방법선취2013년6월지2014년6월우해남성농은총의원진행치료적2형당뇨병환자182례，근거환자뇨산수평적불동분위고뇨산혈증조、저뇨산혈증조화뇨산수평정상조。관찰병비교각조환자생화지표급병발증발생정황。결과고뇨산혈증조화저뇨산혈증조환자총담고순（TC）、삼선감유（TG）、저밀도지단백담고순（LDL‐C）、체질량지수（BMI）균현저고우뇨산수평정상조환자，차이균유통계학의의（P ＜0．05），고뇨산혈증조환자 TC 、TG 、LDL‐C 、BMI 균현저고우저뇨산혈증조환자，차이균유통계학의의（P＜0．05）；고뇨산혈증조화저뇨산혈증조환자고밀도지단백담고순（HDL‐C）현저저우뇨산수평정상조환자，차이유통계학의의（P＜0．05），고뇨산혈증조환자 HDL‐C 현저저우저뇨산혈증조환자，차이유통계학의의（P＜0．05）。3조환자혈압화공복혈당비교차이균무통계학의의（P＞0．05）。고뇨산혈증조환자미혈관병변、대혈관병변、신경병변、뇌혈관병、관심병등혈관병발증발생솔균현저고우저뇨산혈증조환자화뇨산수평정상조환자，차이유통계학의의（P＜0．05），저뇨산혈증조화뇨산수평정상조환자혈관병발증발생정황차이무통계학의의（P＞0．05）。결론고뇨산혈증여환자적비반급혈지대사이상구유현저상관성。고뇨산혈증능구증가2형당뇨병환자대사문란적궤회，병촉진기병발증적발생화발전。
Objective To investigate the mechanism and influence of hyperuricemia to vascular complications in type 2 diabetes .Methods 182 cases of patients with type 2 diabetes in Hainan Agricultural Reclamation General Hospital were selected from June 2013 to June 2014 ,and divided into hyperuricemia group ,hypouricemia group and normal uric acid group ,according to the patients′ uric acid levels .The biochemical indicator levels and the complica‐tion incidences of three groups were observed and compared .Results The levels of TC ,TG ,LDL‐C and BMI of hy‐peruricemia group and hypouricemia group were significantly higher than those of normal uric acid group (P< 0 .05) . And the levels of TC ,TG ,LDL‐C and BMI of hyperuricemia group were significantly higher than those of hypourice‐mia group (P< 0 .05) .The levels of HDL‐C of hyperuricemia group and hypouricemia group were significantly lower than that of normal uric acid group (P < 0 .05) .And the level of HDL‐C of hyperuricemia group was significantly lower than that of hypouricemia group (P< 0 .05) .There was no significant difference of blood pressure and fasting blood glucose among three groups (P > 0 .05) .The incidences of vascular complications ,such as microvascular le‐sions ,macroangiopathy ,neuropathy ,cerebrovascular disease and coronary heart disease ,were significantly higher in hyperuricemia group than in hypouricemia group and normal uric acid group (P < 0 .05) ,however ,there was no sig‐nificant difference between hypouricemia group and normal uric acid group (P> 0 .05) .Conclusion Hyperuricemia is related with the corpulence and the abnormal lipid metabolism of patients with type 2 diabetes .Hyperuricemia can in‐crease the opportunity of metabolic disturbance in patients with type 2 diabetes ,which can promote the development and progression of its complications .