CAJ | 학술논문

文章系统全面检索国内外相关数据库，鉴定并纳入常规西药联合川芎嗪与常规西药对比治疗心绞痛的随机对照试验（RCT），采用国际公认的评价标准对纳入文献的质量进行评价，进而采用 RevMan5.2软件进行 Meta 分析。通过研究分析共纳入16项 RCT，纳入的研究普遍方法学质量较差，只有1篇高质量文献。有16项 RCT 研究结果表明川芎嗪在改善临床症状方面优于对照组；8项研究表明川芎嗪在改善心电图方面具有优势；4项研究表明川芎嗪在改善血液流变学方面优于对照组。纳入的 RCT 并未对不良反应做系统报告，尚不能对安全性得出肯定结论。在常规治疗基础上合用川芎嗪较单纯常规治疗可进一步改善心绞痛的临床症状、心电图疗效，这种改善可能与血液流变学的变化有关，但需要进一步大样本严谨设计的临床试验予以证实、评价川芎嗪治疗冠心病心绞痛的有效性和安全性。
문장계통전면검색국내외상관수거고，감정병납입상규서약연합천궁진여상규서약대비치료심교통적수궤대조시험（RCT），채용국제공인적평개표준대납입문헌적질량진행평개，진이채용 RevMan5.2연건진행 Meta 분석。통과연구분석공납입16항 RCT，납입적연구보편방법학질량교차，지유1편고질량문헌。유16항 RCT 연구결과표명천궁진재개선림상증상방면우우대조조；8항연구표명천궁진재개선심전도방면구유우세；4항연구표명천궁진재개선혈액류변학방면우우대조조。납입적 RCT 병미대불량반응주계통보고，상불능대안전성득출긍정결론。재상규치료기출상합용천궁진교단순상규치료가진일보개선심교통적림상증상、심전도료효，저충개선가능여혈액류변학적변화유관，단수요진일보대양본엄근설계적림상시험여이증실、평개천궁진치료관심병심교통적유효성화안전성。
To systematically review the efficacy and safety of ligustrazine on angina pectoris. The randomized controlled trials(RCT)on the comparison in treatment of angina pectoris with ligustrazine or regu-lar western medicines were identified and included by retrieving the domestic and international databases. The quality of included RCTs was reviewed according to internationally recognized criteria. RevMan5. 2 was used for meta - analysis. There were totally 16 RCTs included and the methodological quality of included RCTs was generally low with only one high - quality study in them. There were 16 RCTs showed that additional use of li-gustrazine was better than regular western medicines in relieving symptoms,8 RCTs showed that ligustrazine had advantages in ameliorating the electrocardiogram effect and 4 RCTs indicated that the treatment group was better than the control group in hemorheology indexes. The safety could not be definitely concluded for the absence of detailed data. The present meta - analysis suggests that on the basis of conventional western medicine,ligustrazine is helpful to improve symptoms,which may be closely related to the improvement of he-morheology indexes,but more rigorous designed and large - sample clinical trials are needed for further con-firmation.