中国继续医学教育
中國繼續醫學教育
중국계속의학교육
China Continuing Medical Education
2015年
30期
40-42
,共3页
血浆肾素浓度%原发性醛固酮增多症%诊断
血漿腎素濃度%原髮性醛固酮增多癥%診斷
혈장신소농도%원발성철고동증다증%진단
Plasma renin concentration%Diagnosis primary%Aldosterone
目的：比较应用血浆醛固酮/血浆肾素活性（PAC/PRA,ARR）及血浆醛固酮/血浆肾素浓度（PAC/PRC,AARR）进行原发性醛固酮增多症（PA）筛查的特异性和敏感性差异,评价测定血浆肾素浓度在PA筛查中的价值。方法对20例经确证实验证实的原发性醛固酮患者和32例经筛查诊断为原发性高血压的患者测定ARR与AARR。结果 AARR和ARR卧位的ROC曲线下面积分别为0.904和0.854， AARR和ARR立位的ROC曲线下面积分别为0.951和0.961。ARR卧位cutoff值在70.5时，诊断原醛的敏感性和特异性分别为80%和78%；ARR立位cutoff值在78时，诊断原醛的敏感性和特异性分别为80%和100%；AARR卧位cutoff值在80.65时，诊断原醛的敏感性和特异性分别为93.3%和75.6%；AARR立位cutoff值在44.65时，诊断原醛的敏感性和特异性分别为100%和87.8%。AARR立位与ARR立位的诊断价值基本相当，有较高准确性，而AARR卧位比ARR卧位诊断价值要高。结论应用AARR与ARR筛查PA的准确性相当， AARR方法较ARR更为简便。
目的：比較應用血漿醛固酮/血漿腎素活性（PAC/PRA,ARR）及血漿醛固酮/血漿腎素濃度（PAC/PRC,AARR）進行原髮性醛固酮增多癥（PA）篩查的特異性和敏感性差異,評價測定血漿腎素濃度在PA篩查中的價值。方法對20例經確證實驗證實的原髮性醛固酮患者和32例經篩查診斷為原髮性高血壓的患者測定ARR與AARR。結果 AARR和ARR臥位的ROC麯線下麵積分彆為0.904和0.854， AARR和ARR立位的ROC麯線下麵積分彆為0.951和0.961。ARR臥位cutoff值在70.5時，診斷原醛的敏感性和特異性分彆為80%和78%；ARR立位cutoff值在78時，診斷原醛的敏感性和特異性分彆為80%和100%；AARR臥位cutoff值在80.65時，診斷原醛的敏感性和特異性分彆為93.3%和75.6%；AARR立位cutoff值在44.65時，診斷原醛的敏感性和特異性分彆為100%和87.8%。AARR立位與ARR立位的診斷價值基本相噹，有較高準確性，而AARR臥位比ARR臥位診斷價值要高。結論應用AARR與ARR篩查PA的準確性相噹， AARR方法較ARR更為簡便。
목적：비교응용혈장철고동/혈장신소활성（PAC/PRA,ARR）급혈장철고동/혈장신소농도（PAC/PRC,AARR）진행원발성철고동증다증（PA）사사적특이성화민감성차이,평개측정혈장신소농도재PA사사중적개치。방법대20례경학증실험증실적원발성철고동환자화32례경사사진단위원발성고혈압적환자측정ARR여AARR。결과 AARR화ARR와위적ROC곡선하면적분별위0.904화0.854， AARR화ARR립위적ROC곡선하면적분별위0.951화0.961。ARR와위cutoff치재70.5시，진단원철적민감성화특이성분별위80%화78%；ARR립위cutoff치재78시，진단원철적민감성화특이성분별위80%화100%；AARR와위cutoff치재80.65시，진단원철적민감성화특이성분별위93.3%화75.6%；AARR립위cutoff치재44.65시，진단원철적민감성화특이성분별위100%화87.8%。AARR립위여ARR립위적진단개치기본상당，유교고준학성，이AARR와위비ARR와위진단개치요고。결론응용AARR여ARR사사PA적준학성상당， AARR방법교ARR경위간편。
Objective Plasma aldosterone / plasma renin activity (PAC/PRA, ARR) and plasma aldosterone / plasma renin concentration (PAC/PRC, AARR) were used to evaluate the speciifcity and sensitivity of PA (PA) screening.MethodsARR and AARR were measured in 20 patients with essential hypertension and 32 patients with essential hypertension conifrmed by confirmatory test.ResultsThe area under the ROC curve of AARR and ARR was 0.854 and 0.904, respectively, and the area under the AARR curve of ROC and ARR was 0.951 and 0.961 respectively. The sensitivity and speciifcity of ARR were 78% and 80% when cutoff value was 70.5, the sensitivity and specificity of ARR was 80% and 100% respectively. The sensitivity and specificity of AARR were 93.3% and 80.65, respectively. The sensitivity and speciifcity of AARR were 100% and 87.8% respectively. The diagnostic value of AARR and ARR was similar to that of, and it had a higher accuracy, and the value of AARR was higher than that of ARR. Conclusion The accuracy of AARR and ARR in PA screening is quite, and the AARR method is more simple than ARR.
