CAJ | 학술논문

目的：评价磷霉素与妥布霉素联合应用对慢性呼吸道感染常见菌的体外抗菌活性，为临床治疗常见菌引起的慢性呼吸道感染提供依据。方法采用琼脂稀释法和肉汤稀释法检测磷霉素与妥布霉素（4∶1）联合应用混合试剂及两种药物单独使用对97株妥布霉素不敏感菌株的最低抑菌浓度（MIC），计算部分抑菌浓度（FIC）指数，应用 FIC 指数来计算和判读两种抗菌药物联合应用对慢性呼吸道感染常见菌的体外抗菌效果。结果与分别单独使用磷霉素和妥布霉素相比，磷霉素和妥布霉素混合试剂对97株妥布霉素不敏感菌株的 MIC 值显著降低，分别有80．4％的菌株表现为协同作用，16．5％的菌株表现为相加作用，3．1％的菌株表现为无关作用，没有拮抗作用发生。结论磷霉素与妥布霉素联合应用对慢性呼吸道感染常见菌主要表现为协同和相加作用，且以协同作用为主。
목적：평개린매소여타포매소연합응용대만성호흡도감염상견균적체외항균활성，위림상치료상견균인기적만성호흡도감염제공의거。방법채용경지희석법화육탕희석법검측린매소여타포매소（4∶1）연합응용혼합시제급량충약물단독사용대97주타포매소불민감균주적최저억균농도（MIC），계산부분억균농도（FIC）지수，응용 FIC 지수래계산화판독량충항균약물연합응용대만성호흡도감염상견균적체외항균효과。결과여분별단독사용린매소화타포매소상비，린매소화타포매소혼합시제대97주타포매소불민감균주적 MIC 치현저강저，분별유80．4％적균주표현위협동작용，16．5％적균주표현위상가작용，3．1％적균주표현위무관작용，몰유길항작용발생。결론린매소여타포매소연합응용대만성호흡도감염상견균주요표현위협동화상가작용，차이협동작용위주。
Objective To evaluate the in vitro activities of combination of fosfomycin and tobramycin (FTI) a‐gainst common pathogenic bacteria of chronic respiratory infections ,so as to provide a base for the treatment of chro‐nic respiratory infections caused by these common pathogenic bacteria .Methods The MIC of FTI (fosfomycin ∶ to‐bramycin was 4 ∶ 1) ,fosfomycin and tobramycin against 97 tobramycin‐resistant strains were detected by agar dilu‐tion method and broth dilution method ,respectively .The fractional inhibitory concentration (FIC) index was calculat‐ed according to MIC values .Results The MIC of FTI against 97 tobramycin‐resistant strains were significantly lower than those of fosfomycin and tobramycin .Fosfomycin and tobramycin showed synergism in 80 .4% of the strains ,ad‐ditivity in 16 .5% of the strains ,non‐interaction in only 3 .1% of the strains .There was no strain antagoniting FTI . Conclusion The combination of tobramycin and fosfomycin have good synergistic and additive effects against com‐mon pathogenic bacteria of chronic respiratory infections ,and synergies is the main performance .