CAJ | 학술논문

目的：探讨无先兆偏头痛患者静息态下脑功能区域低频振荡振幅的变化特点。方法应用功能磁共振成像技术分别采集无先兆偏头痛患者(13例)，以及与偏头痛患者年龄和性别相匹配的健康受试者(16名)静息态的全脑功能图像和数据，通过功能磁共振数据处理工具包对比分析偏头痛患者和正常受试者静息态下脑功能区的低频振荡振幅值差异。结果与健康受试者相比，偏头痛患者低频振荡振幅值显著增强的脑区为右侧颞上回、右侧颞中回颞极、右侧颞上回颞极、右侧颞中回、罗兰迪克岛盖、右侧岛叶(P<0.05)，其中右侧岛叶、右侧前额叶皮层、内侧前额叶皮层相对集中。结论静息态下无先兆偏头痛患者存在多个脑区的功能活动异常增强的特征性变化，为从脑功能层面探讨偏头痛的神经机制特点提供数据支持。
목적：탐토무선조편두통환자정식태하뇌공능구역저빈진탕진폭적변화특점。방법응용공능자공진성상기술분별채집무선조편두통환자(13례)，이급여편두통환자년령화성별상필배적건강수시자(16명)정식태적전뇌공능도상화수거，통과공능자공진수거처리공구포대비분석편두통환자화정상수시자정식태하뇌공능구적저빈진탕진폭치차이。결과여건강수시자상비，편두통환자저빈진탕진폭치현저증강적뇌구위우측섭상회、우측섭중회섭겁、우측섭상회섭겁、우측섭중회、라란적극도개、우측도협(P<0.05)，기중우측도협、우측전액협피층、내측전액협피층상대집중。결론정식태하무선조편두통환자존재다개뇌구적공능활동이상증강적특정성변화，위종뇌공능층면탐토편두통적신경궤제특점제공수거지지。
Objective To investigate the characteristic of brain regional amplitude of low frequency fluctuation(ALFF)in patients with migraine without aura.Methods Thirteen migraine patients without aura and 16 healthy control subjects wel matched in gender and age with migraine patients,were enrol ed and col ected the whole brain functional images and data using resting state functional magnetic resonance imaging (fMRI)technique.Then we compared and analyzed the ALFF value difference between migraine pa-tients and healthy subjects by Resting State fMRI Data Analysis Toolkit.Results Compared with healthy controls,migraine patients showed increased ALFF value in the right superior temporal gyrus,right middle temporal gyrus temporal pole,right superior temporal gyrus temporal pole,right middle temporal gyrus,rolandic operculum and right insula lobe (P<0.05).Among of them,insular lobe, prefrontal cortex,and medial prefrontal cortex in the right brain region relatively centralized and increased.Conclusion During the resting state,migraine patients without aura had the characteristics of the abnormal enhancement of the neural activities and func-tions in multiple brain regions.