国际眼科杂志
國際眼科雜誌
국제안과잡지
International Eye Science
2015年
12期
2105-2106
,共2页
青光眼%眼灌注%波动
青光眼%眼灌註%波動
청광안%안관주%파동
glaucoma%ocular perfusion%fluctuations
目的：探讨眼灌注压波动对青光眼患者病情的影响。<br> 方法：选取我院2013－01／2015－06收治的40例原发性开角型青光眼患者为观察组，同期我院患者家属40例为对照组。监测受试者24 h的眼压、血压与眼灌注压的昼夜波动情况，得出收缩期眼灌注压（ SOPP ）、舒张期眼灌注压（ DOPP）和平均眼灌注压（ MOPP）。采用Pearson线性相关性分析 MOPP 昼夜波动与杯盘比、视野平均缺失（ MD）及图形标准差（ PSD）的相关性。<br> 结果：观察组患者全天和夜间的MOPP、SOPP和DOPP波动均大于对照组（ P＜0．05）。 MOPP昼夜波动与MD存在显著的负相关（ r＝－0．389，95％CI：－0．612～－0．082；P＝0．011）；与 PSD 呈正相关（ r＝0．512，95％CI：0．139～0.782；P＝0．008）；与垂直杯盘比之间无相关性（ r＝0.115，95％CI：0．056～0．369；P＝0．355）。<br> 结论：原发性开角型青光眼患者眼灌注压波动可反映病情的严重程度，可能会导致疾病向严重方向发展，因此通过行24h的灌注压的监测可帮助我们了解原发性开角型青光眼患者全天的眼部血流状态，了解病情发展。
目的：探討眼灌註壓波動對青光眼患者病情的影響。<br> 方法：選取我院2013－01／2015－06收治的40例原髮性開角型青光眼患者為觀察組，同期我院患者傢屬40例為對照組。鑑測受試者24 h的眼壓、血壓與眼灌註壓的晝夜波動情況，得齣收縮期眼灌註壓（ SOPP ）、舒張期眼灌註壓（ DOPP）和平均眼灌註壓（ MOPP）。採用Pearson線性相關性分析 MOPP 晝夜波動與杯盤比、視野平均缺失（ MD）及圖形標準差（ PSD）的相關性。<br> 結果：觀察組患者全天和夜間的MOPP、SOPP和DOPP波動均大于對照組（ P＜0．05）。 MOPP晝夜波動與MD存在顯著的負相關（ r＝－0．389，95％CI：－0．612～－0．082；P＝0．011）；與 PSD 呈正相關（ r＝0．512，95％CI：0．139～0.782；P＝0．008）；與垂直杯盤比之間無相關性（ r＝0.115，95％CI：0．056～0．369；P＝0．355）。<br> 結論：原髮性開角型青光眼患者眼灌註壓波動可反映病情的嚴重程度，可能會導緻疾病嚮嚴重方嚮髮展，因此通過行24h的灌註壓的鑑測可幫助我們瞭解原髮性開角型青光眼患者全天的眼部血流狀態，瞭解病情髮展。
목적：탐토안관주압파동대청광안환자병정적영향。<br> 방법：선취아원2013－01／2015－06수치적40례원발성개각형청광안환자위관찰조，동기아원환자가속40례위대조조。감측수시자24 h적안압、혈압여안관주압적주야파동정황，득출수축기안관주압（ SOPP ）、서장기안관주압（ DOPP）화평균안관주압（ MOPP）。채용Pearson선성상관성분석 MOPP 주야파동여배반비、시야평균결실（ MD）급도형표준차（ PSD）적상관성。<br> 결과：관찰조환자전천화야간적MOPP、SOPP화DOPP파동균대우대조조（ P＜0．05）。 MOPP주야파동여MD존재현저적부상관（ r＝－0．389，95％CI：－0．612～－0．082；P＝0．011）；여 PSD 정정상관（ r＝0．512，95％CI：0．139～0.782；P＝0．008）；여수직배반비지간무상관성（ r＝0.115，95％CI：0．056～0．369；P＝0．355）。<br> 결론：원발성개각형청광안환자안관주압파동가반영병정적엄중정도，가능회도치질병향엄중방향발전，인차통과행24h적관주압적감측가방조아문료해원발성개각형청광안환자전천적안부혈류상태，료해병정발전。
?AIM:To investigate the influence of ocular perfusion pressure fluctuation on glaucoma. <br> ?METHODS:Forty patients with primary open angle glaucoma from January 2013 to June 2015 in our hospital were used as observation group and 40 families were used as control group. Circadian fluctuation of intraocular pressure, blood pressure and ocular perfusion pressure in 24h were determined to obtain systolic ocular perfusion pressure ( SOPP ) , diastolic ocular perfusion pressure ( DOPP ) and mean ocular perfusion pressure ( MOPP ) .Pearson linear correlation was used to analyze the correlation of circadian MOPP fluctuation with cup-disc ratio, mean defect ( MD ) and the picture standard deviation ( PSD) . <br> ?RESULTS:The fluctuation of MOPP, SOPP and DOPP of observation group were significantly higher than those of control group ( P <0.05 ). MOPP fluctuation was negatively correlated with MD ( r=-0.389, 95%CI:-0.612~-0.082;P=0.011), was positively correlated with PSD (r=0.512, 95%CI:0.139 ~0.782;P=0.008);no correlation was found between it and the vertical cup-disc ratio ( r=0.115, 95%CI:0.056~0.369;P=0.355). <br> ?CONCLUSION:Ocular perfusion pressure fluctuations in patients with primary open angle glaucoma may reflect the severity of the disease and may make the situation aggravating. Therefore through perfusion pressure monitor in 24h may help us understand the ocular blood flow and the development of primary open-angle glaucoma.
