CAJ | 학술논문

目的：研究并且总结肝硬化腹水合并低钠血症应用托伐普坦治疗的临床效果，为临床治疗提供参考方案。方法抽取我院消化科收治2013年6月～2015年6月肝硬化腹水合并低钠血症患者112例进行研究。按照患者意愿，分为干预组和空白组。空白组进行常规治疗，干预组增加托伐普坦。比较两组患者疗效。结果干预组24 h尿量高于空白组治疗后（P＜0.05）；干预组体重以及腰围低于空白组治疗后（P＞0.05）。两组比较不良反应发生率不具有统计学意义（P＜0.05）。结论肝硬化腹水合并低钠血症使用托伐普坦临床治疗效果显著。
목적：연구병차총결간경화복수합병저납혈증응용탁벌보탄치료적림상효과，위림상치료제공삼고방안。방법추취아원소화과수치2013년6월～2015년6월간경화복수합병저납혈증환자112례진행연구。안조환자의원，분위간예조화공백조。공백조진행상규치료，간예조증가탁벌보탄。비교량조환자료효。결과간예조24 h뇨량고우공백조치료후（P＜0.05）；간예조체중이급요위저우공백조치료후（P＞0.05）。량조비교불량반응발생솔불구유통계학의의（P＜0.05）。결론간경화복수합병저납혈증사용탁벌보탄림상치료효과현저。
Objective To study and summarize the cirrhotic ascites with hyponatremia application simvastatin treatment's clinical effect, provide reference for clinical treatment.Methods To choose digestive department admitted in June 2013 to June 2015 cirrhotic ascites with 112 patients with hyponatremia were studied. According to the wishes, patients divided into intervention group and the blank group. Blank group routine treatment, the intervention group increased tolvaptan. Compare two groups of patients with curative effect.Results The intervention group had a significantly higher amount of 24 h urine blank group after treatment (P<0.05). Intervention group weight and waist circumference was signiifcantly lower than that of blank group after treatment (P<0.05).Comparing the two groups the incidence of adverse reactions is not statistically signiifcant (P<0.05). Conclusion Liver cirrhosis ascites with hyponatremia using tolvaptan clinical effect is remarkable.