中国基层医药
中國基層醫藥
중국기층의약
Chinese Journal of Primary Medicine and Pharmacy
2015年
22期
3392-3394
,共3页
华峰%李正义%陈吉孟%侯国挺
華峰%李正義%陳吉孟%侯國挺
화봉%리정의%진길맹%후국정
翼状胬肉%角膜缘干细胞%移植%丝裂霉素 C
翼狀胬肉%角膜緣榦細胞%移植%絲裂黴素 C
익상노육%각막연간세포%이식%사렬매소 C
Pterygium%Limbal stem cell%Transplantation%Mitomycin C
目的：观察两种方法治疗原发性翼状胬肉对角膜创面上皮修复及其复发率的影响。方法采用前瞻性对照研究方法，按数字表法将128例患者（128眼）随机分成对照组64例和观察组64例，两组患者均行翼状胬肉切除＋角膜缘干细胞移植术，观察组64例64眼术中加用0．2 mg／mL 丝裂霉素 C（MMC）辅助治疗。观察角膜创面上皮修复速度，随访6～12个月，平均8．5个月，观察两组术后胬肉的复发率。结果术后两组移植片平整，结膜瓣边缘愈合良好。对照组、观察组术后角膜上皮愈合时间分别为（2．13±0．37）d、（2．87±0．41）d，两组差异有统计学意义（t ＝4．91，P ＜0．01）；术后复发率分别6．25％、4．69％，两组差异无统计学意义（χ2＝0．48，P ＞0．05）。结论两种方法治疗翼状胬肉术后的复发率差异无统计学意义，但联合MMC 可导致角膜上皮愈合延迟。
目的：觀察兩種方法治療原髮性翼狀胬肉對角膜創麵上皮脩複及其複髮率的影響。方法採用前瞻性對照研究方法，按數字錶法將128例患者（128眼）隨機分成對照組64例和觀察組64例，兩組患者均行翼狀胬肉切除＋角膜緣榦細胞移植術，觀察組64例64眼術中加用0．2 mg／mL 絲裂黴素 C（MMC）輔助治療。觀察角膜創麵上皮脩複速度，隨訪6～12箇月，平均8．5箇月，觀察兩組術後胬肉的複髮率。結果術後兩組移植片平整，結膜瓣邊緣愈閤良好。對照組、觀察組術後角膜上皮愈閤時間分彆為（2．13±0．37）d、（2．87±0．41）d，兩組差異有統計學意義（t ＝4．91，P ＜0．01）；術後複髮率分彆6．25％、4．69％，兩組差異無統計學意義（χ2＝0．48，P ＞0．05）。結論兩種方法治療翼狀胬肉術後的複髮率差異無統計學意義，但聯閤MMC 可導緻角膜上皮愈閤延遲。
목적：관찰량충방법치료원발성익상노육대각막창면상피수복급기복발솔적영향。방법채용전첨성대조연구방법，안수자표법장128례환자（128안）수궤분성대조조64례화관찰조64례，량조환자균행익상노육절제＋각막연간세포이식술，관찰조64례64안술중가용0．2 mg／mL 사렬매소 C（MMC）보조치료。관찰각막창면상피수복속도，수방6～12개월，평균8．5개월，관찰량조술후노육적복발솔。결과술후량조이식편평정，결막판변연유합량호。대조조、관찰조술후각막상피유합시간분별위（2．13±0．37）d、（2．87±0．41）d，량조차이유통계학의의（t ＝4．91，P ＜0．01）；술후복발솔분별6．25％、4．69％，량조차이무통계학의의（χ2＝0．48，P ＞0．05）。결론량충방법치료익상노육술후적복발솔차이무통계학의의，단연합MMC 가도치각막상피유합연지。
Objective To study two different methods in treatment of primary pterygium surgery on corneal epithelial wound repair and the influence on the recurrence rate.Methods Used prospective controlled study,accord-ing to a number table 128 patients with 128 eyes were randomly divided into control group (64 cases),and observa-tion group (64 cases).The two groups of patients underwent pterygium excision and limbal stem cell transplantation. The observation group (64 eyes)received 0.2 mg/mL mitomycin C of mitomycin -C(MMC)adjuvant therapy. Corneal epithelial wound repair speed was observed.The patients were followed up for 6 -12 months,average 8.5months,the recurrence rate of pterygium was observed in the two groups.Results The grafts were smooth,and the conjunctival flap healed well in the two groups.The postoperative corneal epithelial healing time of the control group and the observation group were (2.13 ±0.37)d,(2.87 ±0.41)d,there was statistically significant difference (t =4.91,P <0.01);The postoperative recurrence rates were 6.25%,4.69% respectively,there was no statistically sig-nificant difference (χ2 =0.48,P >0.05).Conclusion There was no difference in recurrence rate between two kinds of pterygium surgical method,but the combined MMC can cause corneal epithelial healing delay.
