CAJ | 학술논문

目的：探讨男性少、弱、无精症以及胎停育、畸胎、反复性流产等生殖异常患者的细胞遗传学原因。方法：针对我院720例生殖异常患者，做常规技术的外周血淋巴细胞培养，采用 G 显带法进行染色体核型分析。结果：720例生殖异常患者中，检出异常核型69例。其中，多态性核型为49例，包括9qh ＋3例，inv（9）1例，Ds ＋／Gs ＋10例，Yqh ＋35例。 Turner 综合征3例，Klinefelter 综合征12例，平衡易位等5例。结论：染色体核型异常与生殖异常存在密切的关系，异常核型会导致男性少、弱、无精症以及畸胎孕产史和妊娠的反复失败，且染色体多态性与生殖异常关系尤为密切，建议临床应给予足够重视。
목적：탐토남성소、약、무정증이급태정육、기태、반복성유산등생식이상환자적세포유전학원인。방법：침대아원720례생식이상환자，주상규기술적외주혈림파세포배양，채용 G 현대법진행염색체핵형분석。결과：720례생식이상환자중，검출이상핵형69례。기중，다태성핵형위49례，포괄9qh ＋3례，inv（9）1례，Ds ＋／Gs ＋10례，Yqh ＋35례。 Turner 종합정3례，Klinefelter 종합정12례，평형역위등5례。결론：염색체핵형이상여생식이상존재밀절적관계，이상핵형회도치남성소、약、무정증이급기태잉산사화임신적반복실패，차염색체다태성여생식이상관계우위밀절，건의림상응급여족구중시。
Objective :To investigate the cytogenetic reason of patients under going reproductive abnormalities such as azoospermia ,malformation fetus ,recurrent spontaneous abortion .Methods :For examination of 720 patients with re‐productive abnormalities ,as a conventional technique of peripheral blood lymphocyte culture ,by using G banding kary‐otype analysis .Results :Of 720 patients with abnormal reproductive ,69 cases of abnormal karyotypes was detected in this study .Among them ,there were 49 cases of the polymorphism karyotype ,including 3 cases in 9qh + ,1 case in inv (9) ,10 cases in Ds + /Gs + ,35 cases in Yqh + ,3 cases in Turner syndrome ,12 cases in Klinefelter syndrome ,5 cases in balanced translocation .Conclusion :Abnormal chromosome karyotype and there is a close relationship between reproduc‐tive abnormalities and abnormal karyotype ,leading azoospermia ,malformation fetus ,recurrent spontaneous abortion and so on .Further more ,the relationship is closer between chromosome polymorphism and reproductive abnormalities , therefore ,much more attention should be given to this point in clinical .