检验医学与临床
檢驗醫學與臨床
검험의학여림상
Laboratory Medicine and Clinic
2015年
23期
3456-3457,3460
,共3页
妊娠期糖尿病%糖化血红蛋白%口服糖耐量试验
妊娠期糖尿病%糖化血紅蛋白%口服糖耐量試驗
임신기당뇨병%당화혈홍단백%구복당내량시험
gestational diabetes mellitus%HbA1c%oral glucose tolerance test
目的：探讨糖化血红蛋白（HbA1c）在妊娠期糖尿病（GDM ）诊断中的价值。方法选取2014年1～11月在铜陵市妇幼保健院产前门诊做常规产前检查的孕妇411例，于孕24～28周进行口服葡萄糖耐量试验（OG‐TT ），同时测定 HbA1c 。根据 OGTT 结果将孕妇分成3组，即 GDM 组、糖耐量异常组和糖耐量正常组，比较3组之间 OGTT 结果及 HbA1c 水平，评估 HbA1c 在 GDM 筛选中的价值。结果 GDM 组空腹血糖，餐后1 h 、餐后2 h血糖和 HbA1c 水平均高于其他两组，差异有统计学意义（P＜0．05）。受试者工作特征曲线显示，HbA1c 最佳诊断临界值为5．75％，此时灵敏度、特异度、阳性预测值、阴性预测值分别为83．4％、74．8％、67．7％、89．2％。结论HbA1c 在 GDM 筛查中有重要临床价值，可以降低 GDM 漏诊率。
目的：探討糖化血紅蛋白（HbA1c）在妊娠期糖尿病（GDM ）診斷中的價值。方法選取2014年1～11月在銅陵市婦幼保健院產前門診做常規產前檢查的孕婦411例，于孕24～28週進行口服葡萄糖耐量試驗（OG‐TT ），同時測定 HbA1c 。根據 OGTT 結果將孕婦分成3組，即 GDM 組、糖耐量異常組和糖耐量正常組，比較3組之間 OGTT 結果及 HbA1c 水平，評估 HbA1c 在 GDM 篩選中的價值。結果 GDM 組空腹血糖，餐後1 h 、餐後2 h血糖和 HbA1c 水平均高于其他兩組，差異有統計學意義（P＜0．05）。受試者工作特徵麯線顯示，HbA1c 最佳診斷臨界值為5．75％，此時靈敏度、特異度、暘性預測值、陰性預測值分彆為83．4％、74．8％、67．7％、89．2％。結論HbA1c 在 GDM 篩查中有重要臨床價值，可以降低 GDM 漏診率。
목적：탐토당화혈홍단백（HbA1c）재임신기당뇨병（GDM ）진단중적개치。방법선취2014년1～11월재동릉시부유보건원산전문진주상규산전검사적잉부411례，우잉24～28주진행구복포도당내량시험（OG‐TT ），동시측정 HbA1c 。근거 OGTT 결과장잉부분성3조，즉 GDM 조、당내량이상조화당내량정상조，비교3조지간 OGTT 결과급 HbA1c 수평，평고 HbA1c 재 GDM 사선중적개치。결과 GDM 조공복혈당，찬후1 h 、찬후2 h혈당화 HbA1c 수평균고우기타량조，차이유통계학의의（P＜0．05）。수시자공작특정곡선현시，HbA1c 최가진단림계치위5．75％，차시령민도、특이도、양성예측치、음성예측치분별위83．4％、74．8％、67．7％、89．2％。결론HbA1c 재 GDM 사사중유중요림상개치，가이강저 GDM 루진솔。
Objective To investigate the diagnosis value of HbA1c for gestational diabetes mellitus (GDM ) . Methods 411 pregnant women were recruited in the antenatal clinic of Tongling Maternal and Child Health Care Centre from January 2014 to November 2014 .OGTT was processed during 24 to 28 weeks of gestation ,and HbA1c was detected at the same time .According to the OGTT results ,the pregnant women were divided into 3 groups :GDM group ,impaired glucose tolerance group and normal glucose tolerance group .To compare the differences of OG‐TT results and HbA1c levels among 3 groups ,and to assess the value of HbA1c in the screening of GDM .Results The levels of fasting plasma glucose (FPG) ,1 h plasma glucose ,2 h plasma glucose and HbA1c in GDM group were higher than the other two groups ,and the differences were statistically significant(P< 0 .05) .ROC curve showed that the optimal diagnostic cut off value of HbA1c was 5 .75% ,the sensitivity ,specificity ,positive predictive value and negative predictive value were 83 .4% ,74 .8% ,67 .7% ,and 89 .2% ,respectively .Conclusion HbA1c has important clinical value in the screening of GDM ,which can reduce the rate of missed diagnosis .
