CAJ | 학술논문

目的：探讨利培酮与阿立哌唑治疗儿童抽动障碍的临床效果。方法选取我院就诊的儿童抽动障碍患者80例,将其按照数字表法随机分为利培酮组和阿立哌唑组,每组各40例。利培酮组患者采用利培酮治疗,阿立哌唑组应用阿立哌唑治疗。连续治疗12周后,比较两组患儿治疗有效率,采用耶鲁综合抽动严重程度量表(YGTSS)进行疗效的评定和对比,同时观察和记录两组患者不良反应发生情况。结果利培酮组患者治疗的有效率为90.0%(36/40),显效率75.0%(30/40)；阿立哌唑组患者治疗的有效率92.5%(37/40),显效率82.5%(33/40)。两组患者治疗的有效率和显效率差异无统计学意义(u =1.776,0.672,P >0.05)。两组患者用药2周和6周后 YGTSS 评分减分率、运动性抽动评分减少率、发声性抽动评分减少率及全部损害率评分减少率比较差异无统计学意义(P >0.05)。用药12周时阿立哌唑组患者的上述指标改善优于用药2周时(P <0.05)。两组均未出现严重的不良反应,血常规及肝肾功能检查均正常。结论阿立哌唑治疗儿童抽动障碍疗效与利培酮相同,安全性高,值得临床推广。
목적：탐토리배동여아립고서치료인동추동장애적림상효과。방법선취아원취진적인동추동장애환자80례,장기안조수자표법수궤분위리배동조화아립고서조,매조각40례。리배동조환자채용리배동치료,아립고서조응용아립고서치료。련속치료12주후,비교량조환인치료유효솔,채용야로종합추동엄중정도량표(YGTSS)진행료효적평정화대비,동시관찰화기록량조환자불량반응발생정황。결과리배동조환자치료적유효솔위90.0%(36/40),현효솔75.0%(30/40)；아립고서조환자치료적유효솔92.5%(37/40),현효솔82.5%(33/40)。량조환자치료적유효솔화현효솔차이무통계학의의(u =1.776,0.672,P >0.05)。량조환자용약2주화6주후 YGTSS 평분감분솔、운동성추동평분감소솔、발성성추동평분감소솔급전부손해솔평분감소솔비교차이무통계학의의(P >0.05)。용약12주시아립고서조환자적상술지표개선우우용약2주시(P <0.05)。량조균미출현엄중적불량반응,혈상규급간신공능검사균정상。결론아립고서치료인동추동장애료효여리배동상동,안전성고,치득림상추엄。
ABSTRACT:Objective To compare the clinical effects between risperidone and aripiprazole in the treatment of children with tic disorder.Methods A total of 80 cases of children with tic disorder were randomly divided into A group (40 cases)and B group (40 cases).Children with tic disorder in group A were treated by risperidone and children with tic disorder in group B were treated by aripiprazole.After 12 weeks of treatment,the efficacy of the YGTSS score table (Yale comprehensive tic severity scale)was assessed and compared,and the adverse reactions of both groups were observed and recorded.Results The effective rate and significant effective rate in group A were 90%(36/40)and 75% (30/40 ),respectively;the effective rate and significant effective rate were 92.5% (37/40 )and 82.5% (33/40)in group B;there were no significant difference between two groups (u =1.776,0.672,P >0.05). There were no significant difference in YGTSS score reduction fraction,motor tic score reduction rate,sound of tic score reduction rate and total lesion score reduction rate between two groups after 2 and 6 weeks'treatment (P >0.05).At 12 weeks of treatment,the indicators of YGTSS score reduction fraction,motor tic score reduction rate, sound of tic score reduction rate and total lesion score reduction rate were significantly better than at 2 weeks of treatment (P <0.05).There was no serious adverse reactions in both groups and blood and liver function tests were normal.Conclusion Aripiprazole has significant effect as risperidone in the treatment of children with tic disorder, high security and it is worthy of clinic application.