检验医学与临床
檢驗醫學與臨床
검험의학여림상
Laboratory Medicine and Clinic
2015年
23期
3510-3511,3514
,共3页
低密度脂蛋白胆固醇%公式计算法%三酰甘油%胆固醇
低密度脂蛋白膽固醇%公式計算法%三酰甘油%膽固醇
저밀도지단백담고순%공식계산법%삼선감유%담고순
low density lipoprotein cholesterol%formula calculation%triglycerides%cholesterol
目的:对匀相直接测定法测定血清低密度脂蛋白胆固醇(LDL‐C)与 Martin 公式计算法的结果进行对比观察。方法在 Olympus AU 5800型全自动生化分析仪上对790份标本直接测定胆固醇、三酰甘油(TG)、高密度脂蛋白胆固醇、LDL‐C ,同时运用 Martin 公式计算出每份标本的 LDL‐C ,按 TG <1.13 mmol/L 、1.13~2.25 mmol/L 、>2.25~3.39 mmol/L 、>3.39~4.52 mmol/L 、>4.52 mmol/L 分为5组进行统计分析。结果匀相直接测定法与公式法呈良好的正相关,除 TG >4.52 mmol/L 组外,两种方法结果差异均有统计学意义(P <0.05)。两种方法在 LDL‐C 为3.37~4.14 mmol/L ,>4.14 mmol/L 时表现为较好的符合率,在 LDL‐C <3.37 mmol/L时符合率较差。结论两种方法测定结果存在偏差,血清 LDL‐C 的公式计算值高于匀相测定值,建议对于以治疗和监测心血管病为目的患者最好采用直接测定法。
目的:對勻相直接測定法測定血清低密度脂蛋白膽固醇(LDL‐C)與 Martin 公式計算法的結果進行對比觀察。方法在 Olympus AU 5800型全自動生化分析儀上對790份標本直接測定膽固醇、三酰甘油(TG)、高密度脂蛋白膽固醇、LDL‐C ,同時運用 Martin 公式計算齣每份標本的 LDL‐C ,按 TG <1.13 mmol/L 、1.13~2.25 mmol/L 、>2.25~3.39 mmol/L 、>3.39~4.52 mmol/L 、>4.52 mmol/L 分為5組進行統計分析。結果勻相直接測定法與公式法呈良好的正相關,除 TG >4.52 mmol/L 組外,兩種方法結果差異均有統計學意義(P <0.05)。兩種方法在 LDL‐C 為3.37~4.14 mmol/L ,>4.14 mmol/L 時錶現為較好的符閤率,在 LDL‐C <3.37 mmol/L時符閤率較差。結論兩種方法測定結果存在偏差,血清 LDL‐C 的公式計算值高于勻相測定值,建議對于以治療和鑑測心血管病為目的患者最好採用直接測定法。
목적:대균상직접측정법측정혈청저밀도지단백담고순(LDL‐C)여 Martin 공식계산법적결과진행대비관찰。방법재 Olympus AU 5800형전자동생화분석의상대790빈표본직접측정담고순、삼선감유(TG)、고밀도지단백담고순、LDL‐C ,동시운용 Martin 공식계산출매빈표본적 LDL‐C ,안 TG <1.13 mmol/L 、1.13~2.25 mmol/L 、>2.25~3.39 mmol/L 、>3.39~4.52 mmol/L 、>4.52 mmol/L 분위5조진행통계분석。결과균상직접측정법여공식법정량호적정상관,제 TG >4.52 mmol/L 조외,량충방법결과차이균유통계학의의(P <0.05)。량충방법재 LDL‐C 위3.37~4.14 mmol/L ,>4.14 mmol/L 시표현위교호적부합솔,재 LDL‐C <3.37 mmol/L시부합솔교차。결론량충방법측정결과존재편차,혈청 LDL‐C 적공식계산치고우균상측정치,건의대우이치료화감측심혈관병위목적환자최호채용직접측정법。
Objective To compare the results of low density lipoprotein cholesterol (LDL‐C) detected by Mar‐tin formula calculation and homogenous direct measurement method .Methods TC ,TG ,LDL‐C and HDL‐C of 790 samples were determined directly by American Olympus AU5800 automatic biochemistry analyzer .LDL‐C level of each sample was calculated by Martin formula at the same time .Samples were divided into five groups according to TG levels (< 1 .13 mmol/L ,1 .13 - 2 .25 mmol/L ,> 2 .25 - 3 .39 mmol/L ,> 3 .39 - 4 .52 mmol/L ,and > 4 .52 mmol/L) ,and statistic analysis was performed among the groups .Results The results of homogenous direct meas‐urement and Martin formula calculation showed a good positive correlation .The results of homogenous direct meas‐urement were significantly different from those of Martin formula calculation among the other four groups except for TG > 4 .52 mmol/L group (P< 0 .05) .The two methods showed high coincidence when the LDL‐C level was 3 .37 -4 .14 mmol/L and > 4 .14 mmol/L .When the LDL‐C level was less than 3 .37 mmol/L ,the coincidence of the two method reduced .Conclusion The LDL‐C result of Martin formula calculation is higher than that of homogenous di‐rect measurement method ,with an obvious bias .It suggests that homogenous direct measurement method is a better choice for the treatment or monitor in patients with cardiovascular disease .