CAJ | 학술논문

目的：对匀相直接测定法测定血清低密度脂蛋白胆固醇（LDL‐C）与 Martin 公式计算法的结果进行对比观察。方法在 Olympus AU 5800型全自动生化分析仪上对790份标本直接测定胆固醇、三酰甘油（TG）、高密度脂蛋白胆固醇、LDL‐C ，同时运用 Martin 公式计算出每份标本的 LDL‐C ，按 TG ＜1．13 mmol／L 、1．13～2．25 mmol／L 、＞2．25～3．39 mmol／L 、＞3．39～4．52 mmol／L 、＞4．52 mmol／L 分为5组进行统计分析。结果匀相直接测定法与公式法呈良好的正相关，除 TG ＞4．52 mmol／L 组外，两种方法结果差异均有统计学意义（P ＜0．05）。两种方法在 LDL‐C 为3．37～4．14 mmol／L ，＞4．14 mmol／L 时表现为较好的符合率，在 LDL‐C ＜3．37 mmol／L时符合率较差。结论两种方法测定结果存在偏差，血清 LDL‐C 的公式计算值高于匀相测定值，建议对于以治疗和监测心血管病为目的患者最好采用直接测定法。
목적：대균상직접측정법측정혈청저밀도지단백담고순（LDL‐C）여 Martin 공식계산법적결과진행대비관찰。방법재 Olympus AU 5800형전자동생화분석의상대790빈표본직접측정담고순、삼선감유（TG）、고밀도지단백담고순、LDL‐C ，동시운용 Martin 공식계산출매빈표본적 LDL‐C ，안 TG ＜1．13 mmol／L 、1．13～2．25 mmol／L 、＞2．25～3．39 mmol／L 、＞3．39～4．52 mmol／L 、＞4．52 mmol／L 분위5조진행통계분석。결과균상직접측정법여공식법정량호적정상관，제 TG ＞4．52 mmol／L 조외，량충방법결과차이균유통계학의의（P ＜0．05）。량충방법재 LDL‐C 위3．37～4．14 mmol／L ，＞4．14 mmol／L 시표현위교호적부합솔，재 LDL‐C ＜3．37 mmol／L시부합솔교차。결론량충방법측정결과존재편차，혈청 LDL‐C 적공식계산치고우균상측정치，건의대우이치료화감측심혈관병위목적환자최호채용직접측정법。
Objective To compare the results of low density lipoprotein cholesterol (LDL‐C) detected by Mar‐tin formula calculation and homogenous direct measurement method .Methods TC ,TG ,LDL‐C and HDL‐C of 790 samples were determined directly by American Olympus AU5800 automatic biochemistry analyzer .LDL‐C level of each sample was calculated by Martin formula at the same time .Samples were divided into five groups according to TG levels (< 1 .13 mmol/L ,1 .13 - 2 .25 mmol/L ,> 2 .25 - 3 .39 mmol/L ,> 3 .39 - 4 .52 mmol/L ,and > 4 .52 mmol/L) ,and statistic analysis was performed among the groups .Results The results of homogenous direct meas‐urement and Martin formula calculation showed a good positive correlation .The results of homogenous direct meas‐urement were significantly different from those of Martin formula calculation among the other four groups except for TG > 4 .52 mmol/L group (P< 0 .05) .The two methods showed high coincidence when the LDL‐C level was 3 .37 -4 .14 mmol/L and > 4 .14 mmol/L .When the LDL‐C level was less than 3 .37 mmol/L ,the coincidence of the two method reduced .Conclusion The LDL‐C result of Martin formula calculation is higher than that of homogenous di‐rect measurement method ,with an obvious bias .It suggests that homogenous direct measurement method is a better choice for the treatment or monitor in patients with cardiovascular disease .