检验医学与临床
檢驗醫學與臨床
검험의학여림상
Laboratory Medicine and Clinic
2015年
23期
3505-3506,3509
,共3页
脑卒中后抑郁%黛力新%氟西汀
腦卒中後抑鬱%黛力新%氟西汀
뇌졸중후억욱%대력신%불서정
post stroke depression%deanxit%floxitine
目的：探讨采用黛力新联合氟西汀治疗老年脑卒中后抑郁患者的临床疗效及安全性。方法选取2010年3月至2013年7月在扬州市五台山医院确诊并治疗的老年脑卒中后抑郁患者68例，分为对照组和观察组，每组34例。对照组采用氟西汀治疗，观察组在对照组基础上联合服用黛力新，分别在治疗前，治疗后1、4、12周对比两组患者的日常生活能力（ADL）评分和汉密尔顿抑郁量表（HAMD）评分，并对比两组患者的临床疗效及不良反应。结果两组治疗前 HAMD 评分、ADL 评分比较差异无统计学意义（P＞0．05）；与治疗前相比，治疗1、4、12周后两组患者 HAMD 、ADL 评分均明显下降，差异有统计学意义（P＜0．05）；与对照组相比，观察组 HAMD 、ADL 评分治疗后各个时间点降低更明显，差异均有统计学意义（P＜0．05）。对照组患者总有效率为47．1％（16／34），明显低于观察组的73．5％（25／34），差异有统计学意义（χ2＝4．096，P＜0．05）。两组患者不良反应发生率比较差异无统计学意义（χ2＝0．078，P＞0．05）。结论与单独采用氟西汀治疗相比，黛力新联合氟西汀用于治疗老年脑卒中后抑郁可显著改善患者的抑郁状态，同时提高了患者的生活自理能力；安全有效，值得临床推广应用。
目的：探討採用黛力新聯閤氟西汀治療老年腦卒中後抑鬱患者的臨床療效及安全性。方法選取2010年3月至2013年7月在颺州市五檯山醫院確診併治療的老年腦卒中後抑鬱患者68例，分為對照組和觀察組，每組34例。對照組採用氟西汀治療，觀察組在對照組基礎上聯閤服用黛力新，分彆在治療前，治療後1、4、12週對比兩組患者的日常生活能力（ADL）評分和漢密爾頓抑鬱量錶（HAMD）評分，併對比兩組患者的臨床療效及不良反應。結果兩組治療前 HAMD 評分、ADL 評分比較差異無統計學意義（P＞0．05）；與治療前相比，治療1、4、12週後兩組患者 HAMD 、ADL 評分均明顯下降，差異有統計學意義（P＜0．05）；與對照組相比，觀察組 HAMD 、ADL 評分治療後各箇時間點降低更明顯，差異均有統計學意義（P＜0．05）。對照組患者總有效率為47．1％（16／34），明顯低于觀察組的73．5％（25／34），差異有統計學意義（χ2＝4．096，P＜0．05）。兩組患者不良反應髮生率比較差異無統計學意義（χ2＝0．078，P＞0．05）。結論與單獨採用氟西汀治療相比，黛力新聯閤氟西汀用于治療老年腦卒中後抑鬱可顯著改善患者的抑鬱狀態，同時提高瞭患者的生活自理能力；安全有效，值得臨床推廣應用。
목적：탐토채용대력신연합불서정치료노년뇌졸중후억욱환자적림상료효급안전성。방법선취2010년3월지2013년7월재양주시오태산의원학진병치료적노년뇌졸중후억욱환자68례，분위대조조화관찰조，매조34례。대조조채용불서정치료，관찰조재대조조기출상연합복용대력신，분별재치료전，치료후1、4、12주대비량조환자적일상생활능력（ADL）평분화한밀이돈억욱량표（HAMD）평분，병대비량조환자적림상료효급불량반응。결과량조치료전 HAMD 평분、ADL 평분비교차이무통계학의의（P＞0．05）；여치료전상비，치료1、4、12주후량조환자 HAMD 、ADL 평분균명현하강，차이유통계학의의（P＜0．05）；여대조조상비，관찰조 HAMD 、ADL 평분치료후각개시간점강저경명현，차이균유통계학의의（P＜0．05）。대조조환자총유효솔위47．1％（16／34），명현저우관찰조적73．5％（25／34），차이유통계학의의（χ2＝4．096，P＜0．05）。량조환자불량반응발생솔비교차이무통계학의의（χ2＝0．078，P＞0．05）。결론여단독채용불서정치료상비，대력신연합불서정용우치료노년뇌졸중후억욱가현저개선환자적억욱상태，동시제고료환자적생활자리능력；안전유효，치득림상추엄응용。
Objective To discuss the clinical effects and safety of combination of deanxit and floxitine in the treatment of elder patients with post stroke depression (PSD) .Methods From March 2010 to July 2013 ,68 PSD pa‐tients were collected in Yangzhou Wutaishan Hospital and divided into control group (n= 34) and observation group (n= 34) .Patients of control group were treated by floxitine ,and patients of observation group were treated by deanx‐it combined with floxitine .The scores of activity of daily living (ADL ) and Hamilton depression rating scale (HAMD) of two groups were compared before the treatment and 1 ,4 and 12 weeks after the treatment ,respectively . The clinical effects and complications of two groups were also compared .Results Before the treatment ,HAMD and ADL scores of two groups had no significant differences (P > 0 .05) .Compared with before the treatment ,HAMD and ADL scores of two groups all significantly decreased 1 ,4 and 12 weeks after the treatment (P < 0 .05) .HAMD and ADL scores of observation group were significantly lower than control group at every time point (P< 0 .05) .The effective rate of control group [73 .5% (25/34)] was significantly lower than observation group [47 .1% (16/34)] , with statistical difference (χ2 = 4 .096 ,P < 0 .05) .There was no significant difference of complication incidence be‐tween two groups (χ2 = 0 .078 ,P> 0 .05) .Conclusion Compared with fluorine treatment ,combination of deanxit and floxitine can significantly improve the depressive state of PSD elder patients and patients′self‐care abilities ,which is safe and effective ,and worthy of clinical application .
